Time to diagnosis of brain tumors in children: A single‐centre experience

Molineus, Anja; Boxberger, Nicole; Redlich, Antje; Vorwerk, Peter

doi:10.1111/ped.12095

Cited by 28 publications

(25 citation statements)

References 27 publications

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“…We found that gliomas were the most frequent tumors type, followed by embryonal tumors, as reported in previous publications [5,9]. For topography, the most frequent locations were cerebellum and frontal lobe, as reported in other studies in young adults [9,10]. As expected from the literature [11,12], we found a significant decreasing trend with increasing age for embryonal tumors, and an increasing trend with age for meningioma and other non-neuroepithelial tumors.…”

Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 88%

“…Other nonneu-roepi-thelial 47 (5) 28 (5) 19 (5) 11 (3) 9 (4) 2 (1) 12 (4) 5 (3) 7 (5) 24 (10) 14 (10) (23) 102 (27) 52 (24) 50 (31) 62 (21) 39 (25) 23 (17) 37 (16) 21 (15) (13) 37 (10) 21 (10) 16 (10) 50 (17) 33 (21) 17 (13) 56 (24) 40 (28) 16 (18) < 0.01 Temporal lobe 103 (11) 55 (11) 48 (12) 32 (9) 17 (8) 15 (9) 37 (13) 17 (11) 20 (15) 34 (15) 21 (15) 13 (15) 0.02…”

Section: Laterality Of Symptoms Was Reported For Only 17% Of Cases Wiunclassified

“…Cerebral ventricles 88 (10) 51 (10) 37 (10) 37 (10) 27 (13) 10 (6) 33 (11) 14 (9) 19 (14) 18 (8) 10 (7) 8 (9) 14 (6) 8 (6) 6 (7) 0.04…”

Section: Laterality Of Symptoms Was Reported For Only 17% Of Cases Wiunclassified

“…Overlapping lesion of the brain 83 (9) 41 (8) 42 (11) 47 (12) 22 (10) 25 (15) 15 (5) 7 (4) 8 (6) 21 (9) 12 (8) 9 (10) 0.07…”

Section: Laterality Of Symptoms Was Reported For Only 17% Of Cases Wimentioning

confidence: 99%

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Clinical presentation of young people (10–24 years old) with brain tumors: results from the international MOBI-Kids study

et al. 2020

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Introduction We used data from MOBI-Kids, a 14-country international collaborative case-control study of brain tumors (BTs), to study clinical characteristics of the tumors in older children (10 years or older), adolescents and young adults (up to the age of 24). Methods Information from clinical records was obtained for 899 BT cases, including signs and symptoms, symptom onset, diagnosis date, tumor type and location. Results Overall, 64% of all tumors were low-grade, 76% were neuroepithelial tumors and 62% gliomas. There were more males than females among neuroepithelial and embryonal tumor cases, but more females with meningeal tumors. The most frequent locations were cerebellum (22%) and frontal (16%) lobe. The most frequent symptom was headaches (60%), overall, as well as for gliomas, embryonal and 'non-neuroepithelial' tumors; it was convulsions/seizures for neuroepithelial tumors other than glioma, and visual signs and symptoms for meningiomas. A cluster analysis showed that headaches and nausea/ vomiting was the only combination of symptoms that exceeded a cutoff of 50%, with a joint occurrence of 67%. Overall, the median time from first symptom to diagnosis was 1.42 months (IQR 0.53-4.80); it exceeded 1 year in 12% of cases, though no particular symptom was associated with exceptionally long or short delays. Conclusions This is the largest clinical epidemiology study of BT in young people conducted so far. Many signs and symptoms were identified, dominated by headaches and nausea/vomiting. Diagnosis was generally rapid but in 12% diagnostic delay exceeded 1 year with none of the symptoms been associated with a distinctly long time until diagnosis.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 88%

Section: Laterality Of Symptoms Was Reported For Only 17% Of Cases Wiunclassified

“…Cerebral ventricles 88 (10) 51 (10) 37 (10) 37 (10) 27 (13) 10 (6) 33 (11) 14 (9) 19 (14) 18 (8) 10 (7) 8 (9) 14 (6) 8 (6) 6 (7) 0.04…”

Section: Laterality Of Symptoms Was Reported For Only 17% Of Cases Wiunclassified

“…Overlapping lesion of the brain 83 (9) 41 (8) 42 (11) 47 (12) 22 (10) 25 (15) 15 (5) 7 (4) 8 (6) 21 (9) 12 (8) 9 (10) 0.07…”

Section: Laterality Of Symptoms Was Reported For Only 17% Of Cases Wimentioning

confidence: 99%

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Clinical presentation of young people (10–24 years old) with brain tumors: results from the international MOBI-Kids study

et al. 2020

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Efficacy of dual‐task training on stability and function in children with ataxia after medulloblastoma resection: A randomized controlled trial

Selim,

Elshafey,

El‐Ayadi

et al. 2023

Pediatric Blood & Cancer

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Background/objectiveIn children, medulloblastoma (MB) is the most prevalent posterior fossa tumor. The first line of treatment is maximal safe resection. Therefore, symptoms of ataxia are commonly seen. Training the brain on balance and cognitive tasks makes balance more automatic than without cognitive tasks. The goal was to assess the effectiveness of dual‐task practice on balance after MB excision in children with ataxia.MethodsThirty children with ataxia after MB resection at Children Cancer Hospital Egypt were randomized into two equal groups. Exercises for mobility, balance, and gait training were given to both groups. The research group underwent a specific dual‐task program (balance and cognitive). The program ran 3 days per week for 8 weeks. Children were evaluated before and after the treatment regimen using the Scale of Assessment and Rating of Ataxia (SARA), the HUMAC Balance System, Pediatric Balance Scale, and Functional Independent Measurement. All children's legal guardians signed an ethical agreement.ResultsA notable improvement in balance was found in the dual group in Pediatric Balance Scale (PBS) (p = .028) and stability test (p = .0001) in favor of the study group. No discernible difference was observed in the Functional Independent Measurement score among the two groups (p = .158), although there was a statistically significant increase in both groups after treatment.ConclusionDual‐task program is more effective than traditional physical therapy alone in improving balance in children with ataxia after MB resection.

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Patient‐ and parent‐reported diagnostic delay in children with central nervous system tumors in Denmark

Weile,

Helligsoe,

von Holstein

et al. 2024

Pediatric Blood & Cancer

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BackgroundDiagnostic delays in childhood tumors of the central nervous system (CNS) pose a significant challenge. The aim of this study was to map diagnostic delay and presenting symptoms in Denmark.MethodsThe study was a retrospective questionnaire study, mapping delay and symptoms in pediatric patients (0–17 years), diagnosed with a CNS tumor from 2015 to 2019. Descriptive analysis was performed to measure delay in days, reported as total diagnostic interval (TDI), patient interval (PI), and diagnostic interval (DI). Analysis of symptoms, contacts to healthcare professionals, and socioeconomic status was also performed.ResultsWe included 89 patients (median age 7.0 years, 54% male). The TDI was median of 106 days (range: 0–2694 days). Low‐grade tumors had longer TDI than high‐grade tumors (125 vs. 43 days; p ≤ .02). Patients aged 15–17 displayed the longest TDI (median 665 days). Number of symptoms at onset were inversely associated with longer TDI in patients presenting one symptom (247 days) and patients presenting two to three (110 days) or greater than three complaints (66 days). PI was not associated with sex (p = .14), tumor grade (p = .63), location (p = .32), or socioeconomic status (p = .82). Most frequent single complaint at onset was headache (19%), most frequent combination of symptoms was headache and vomiting (60%).ConclusionWe found TDIs longer than reported in contemporary publications. TDI was longer in patients with low‐grade tumors and only few symptoms at the time of onset. The findings support the crucial need of awareness and improved diagnostic tools to recognize and interpret symptoms to promote timely diagnosis.

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Time to diagnosis of brain tumors in children: A single‐centre experience

Cited by 28 publications

References 27 publications

Clinical presentation of young people (10–24 years old) with brain tumors: results from the international MOBI-Kids study

Clinical presentation of young people (10–24 years old) with brain tumors: results from the international MOBI-Kids study

Efficacy of dual‐task training on stability and function in children with ataxia after medulloblastoma resection: A randomized controlled trial

Patient‐ and parent‐reported diagnostic delay in children with central nervous system tumors in Denmark

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