Abstract:Purpose
The clinical relevance of different time-to-deterioration (TTD) definitions for patient-reported outcomes were explored.
Methods
TTD definitions differing by reference score and deterioration event were used to analyse data from the phase 3 FLAURA trial of first-line osimertinib versus erlotinib or gefitinib in patients with EGFR-mutated advanced non-small cell lung cancer. Pre-specified key symptoms were fatigue, appetite loss, cough, chest pain a… Show more
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