Time to completed redistribution of thallium-201 in exercise myocardial scintigraphy: Relationship to the degree of coronary artery stenosis

Gutman, Jack; Berman, Daniel S.; Freeman, Michael R.; Rozanski, Alan; Maddahi, Jamshid; Waxman, Alan D.; Swan, H.J.C.

doi:10.1016/0002-8703(83)90642-7

Cited by 141 publications

(28 citation statements)

References 23 publications

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“…28,29 Whether the same added value of redistribution imaging could be derived from rest and 4-hour redistribution imaging performed before stress testing using a potential practical protocol is a question that was not addressed here.…”

Section: Study Limitationsmentioning

confidence: 99%

Incremental Prognostic Value of Rest-Redistribution ²⁰¹ Tl Single-Photon Emission Computed Tomography

Sharir

Berman²,

Lewin³

et al. 1999

Circulation

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Background-The incremental prognostic value of rest-redistribution 201 Tl compared with stress and rest perfusion abnormalities has not been defined. Methods and Results-We identified 458 patients who underwent rest 201 Tl /stress (exercise or adenosine) 99m Tc sestamibi single-photon emission computed tomography (SPECT) and had late (18 to 24 hours) 201 Tl imaging, were not revascularized within 60 days of SPECT, and were followed up at Ͼ1 year. SPECT images were visually analyzed with the use of a 20-segment model on a scale of 0 to 4. Thirty-seven cardiac deaths (CDs) and 17 nonfatal myocardial infarctions occurred. Univariate Cox proportional hazards analysis showed that the presence of a large amount of rest

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Section: Study Limitationsmentioning

confidence: 99%

Incremental Prognostic Value of Rest-Redistribution ²⁰¹ Tl Single-Photon Emission Computed Tomography

Sharir

Berman²,

Lewin³

et al. 1999

Circulation

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“…Redistribution of T1-201 can potentially occur during the 35 minutes that pass between injection and completion of SPECT sequence 15 whereas Tc-MIBI has minimal redistribution. 1,16 Defect intensity is the same on SPECT of either agent.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Myocardial Perfusion with Single Photon Emission Tomography

Mohamadiyeh

Arafa

El-Desouki

1994

Annals of Saudi Medicine

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In order to compare Tc-99m-Sestamibi to T1-201 in the assessment of myocardial perfusion in the presence of coronary artery disease, 100 patients were studied with single photon emission computerized tomography (SPECT). Segmental analysis was carried out on 77 patients who underwent cardiac angiogram. The overall sensitivity and specificity rates in patients with myocardial infarction were respectively 92.5% and 98% for MIBI, 86.6% and 95% for T1; whereas in patients with chest pain, they were respectively 76.7% and 80% for MIBI, 69.8% and 70.5% for T1. Tc-MIBI correctly detected 11 lesions that were normal on T1-201, whereas the latter detected one lesion that was missed by Tc-MIBI. Concluding, we have the impression that Tc-MIBI not only correlated well with T1-201 but also showed marginal superiority over T1-201. Thus, Tc-MIBI is a valid alternative to T1 whenever the latter is not available. Ann Saudi Med 1994;14(2):97-101.

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“…The phenomenon of rapid washout (early redistribution) must be considered during the first 20 min. This may lead to false positive interpretation of slow washout after 4 h (Gutman et al 1983). On the other hand, a perfusion defect at delayed scintigraphy does not necessarily indicate myocardial infarction since improvement following surgical intervention has often been found to suggest that severe ischemia may be the cause of this problem (Okada et al 1985;Shelbert 1988).…”

Section: Timing Of Initial and Delayed Imaging Initial Imagingmentioning

confidence: 99%

Is quantitative analysis superior to visual analysis of planar thallium 201 myocardial exercise scintigraphy in the evaluation of coronary artery disease?

et al. 1990

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Abstract. Quantitative analysis of myocardial exercise scintigraphy has been previously reported to be superior to visual image interpretation for detection of the presence and extent of coronary artery disease. Computer analysis of perfusion defects and washout rate of thallium 201 was performed on scintigrams from a group of 131 consecutive patients (prospective group), using criteria defined from a previous group of 72 patients (initial group), and compared with visual interpretation of scintigrams for detection and evaluation of coronary artery disease. The sensitivity of the quantitative technique with regard to overall detection of coronary artery disease was not significantly different from the visual method (69% and 74%, respectively), whereas the specificity was higher (86% and 68%). Quantitative analysis did not increase the sensitivity of thallium imaging over the visual method in the left anterior descending artery (46% vs 65%) and the right coronary artery (51% vs 72%) but did increase sensitivity in the left circumflex artery (75% vs 47%). Whereas in the initial group quantitative analysis resulted in a better identification of multivessel disease (sensitivity 81% vs 57%), in the prospective group sensitivity decreased (54% vs 67%) without significant loss of specificity. The initial group had a 40 % incidence of three-vessel disease and the prospective group, 22% (P<0.05). One-vessel disease was higher in the prospective group (32% vs 11%, P< 0.05). Thus, assessing the quantitative technique in a larger prospective patient population, there was no improvement of Offprint requests to." E.K.J. Pauwels detection of the presence and extent of coronary artery disease when compared with visual interpretation.

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Time to completed redistribution of thallium-201 in exercise myocardial scintigraphy: Relationship to the degree of coronary artery stenosis

Cited by 141 publications

References 23 publications

Incremental Prognostic Value of Rest-Redistribution ²⁰¹ Tl Single-Photon Emission Computed Tomography

Incremental Prognostic Value of Rest-Redistribution ²⁰¹ Tl Single-Photon Emission Computed Tomography

Assessment of Myocardial Perfusion with Single Photon Emission Tomography

Is quantitative analysis superior to visual analysis of planar thallium 201 myocardial exercise scintigraphy in the evaluation of coronary artery disease?

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Time to completed redistribution of thallium-201 in exercise myocardial scintigraphy: Relationship to the degree of coronary artery stenosis

Cited by 141 publications

References 23 publications

Incremental Prognostic Value of Rest-Redistribution 201 Tl Single-Photon Emission Computed Tomography

Incremental Prognostic Value of Rest-Redistribution 201 Tl Single-Photon Emission Computed Tomography

Assessment of Myocardial Perfusion with Single Photon Emission Tomography

Is quantitative analysis superior to visual analysis of planar thallium 201 myocardial exercise scintigraphy in the evaluation of coronary artery disease?

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Incremental Prognostic Value of Rest-Redistribution ²⁰¹ Tl Single-Photon Emission Computed Tomography

Incremental Prognostic Value of Rest-Redistribution ²⁰¹ Tl Single-Photon Emission Computed Tomography