Time, Sleep, and Stimulus Equivalence-Based Relational Memory

Dymond, Simon; Llewellyn, Samuel

doi:10.1007/s40732-019-00343-8

Cited by 3 publications

(3 citation statements)

References 43 publications

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“…Relational memory is the ability to integrate multiple sources of knowledge, infer indirect associations between stimuli, and make decisions when presented with novel situations 1,2 .…”

Section: Introductionmentioning

confidence: 99%

“…Relational memory is the ability to integrate multiple sources of knowledge, infer indirect associations between stimuli, and make decisions when presented with novel situations (Dymond & Llewellyn, 2019; Lerner & Gluck, 2019). One typical example of such integration is transitive inference (TI), or the deduction of the rankings of non-adjacent members of a linear hierarchy which has been presented in terms of adjacent members.…”

Section: Introductionmentioning

confidence: 99%

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Memory reactivation in slow wave sleep enhances relational learning

Santamaría

Kashif

McGinley

et al. 2022

Preprint

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Memories are often strengthened by sleep, which can also boost integration and relational learning. This process can be facilitated by a technique called targeted memory reactivation (TMR), which involves re-applying cues that were associated with learned material during wake during subsequent sleep. We tested whether TMR during slow wave sleep increases the solving of inference pairs in a transitive inference task. Because the slow oscillation up-state is thought to be more important for plasticity, we also asked whether stimulation is more beneficial at this phase. Our data show that TMR can boost inference on the most difficult pairs, but only when presented during the down-to-up transition of the slow oscillation. Such stimulation was associated with classifiable replay, whereas stimulation of the up-to-down transition produced no apparent replay and led to below-chance performance. These findings demonstrate that targeted memory replay in sleep can play a role in integration and relational learning.

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“…Relational memory is the ability to integrate multiple sources of knowledge, infer indirect associations between stimuli, and make decisions when presented with novel situations 1,2 .…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Memory reactivation in slow wave sleep enhances relational learning

Santamaría

Kashif

McGinley

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Relational memory is the ability to integrate multiple sources of knowledge, infer indirect associations between stimuli, and make decisions when presented with novel situations 1,2 . One example of such integration is transitive inference (TI), or the deduction of the rankings of non-adjacent members of a linear hierarchy which has been presented via exposure to adjacent pairs.…”

mentioning

confidence: 99%

Memory reactivation in slow wave sleep enhances relational learning in humans

Santamaria,

Kashif,

McGinley

et al. 2024

Commun Biol

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Sleep boosts the integration of memories, and can thus facilitate relational learning. This benefit may be due to memory reactivation during non-REM sleep. We set out to test this by explicitly cueing reactivation using a technique called targeted memory reactivation (TMR), in which sounds are paired with learned material in wake and then softly played during subsequent sleep, triggering reactivation of the associated memories. We specifically tested whether TMR in slow wave sleep leads to enhancements in inferential thinking in a transitive inference task. Because the Up-phase of the slow oscillation is more responsive to cues than the Down-phase, we also asked whether Up-phase stimulation is more beneficial for such integration. Our data show that TMR during the Up-Phase boosts the ability to make inferences, but only for the most distant inferential leaps. Up-phase stimulation was also associated with detectable memory reinstatement, whereas Down-phase stimulation led to below-chance performance the next morning. Detection of memory reinstatement after Up-state stimulation was negatively correlated with performance on the most difficult inferences the next morning. These findings demonstrate that cueing memory reactivation at specific time points in sleep can benefit difficult relational learning problems.

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Memory reactivation in slow wave sleep enhances relational learning.

Kashif

McGinley²,

Lewis

et al. 2023

Preprint

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Sleep has been shown to boost the integration of memories, and thus to facilitate relational learning. This benefit is thought to rely upon memory reactivation during non-REM sleep. We set out to test this possibility by explicitly cueing such reactivation using a technique called targeted memory reactivation (TMR), in which sounds are paired with learned material in wake and then softly played back to the participant in sleep, triggering reactivation of the associated memories. Specifically, we tested whether TMR during slow wave sleep leads to enhancements in inferential thinking in a transitive inference task. Because the Up-phase of the slow oscillation is more responsive to external cues than the Down-phase, we also asked whether stimulation at this specific phase is more beneficial for such integration. Our data show that Up-phase TMR boosts the ability to make inferences, but only for the most distant inferential leaps. Such stimulation was also associated with detectable memory reinstatement, whereas Down-phase stimulation produced no such trace and led to below-chance performance. These findings demonstrate that cueing memory reactivation at the right time points in sleep can provide a direct benefit to difficult relational learning problems.

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Time, Sleep, and Stimulus Equivalence-Based Relational Memory

Cited by 3 publications

References 43 publications

Memory reactivation in slow wave sleep enhances relational learning

Memory reactivation in slow wave sleep enhances relational learning

Memory reactivation in slow wave sleep enhances relational learning in humans

Memory reactivation in slow wave sleep enhances relational learning.

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