Time-Shift Homotopic Connectivity in Mesial Temporal Lobe Epilepsy

Xu, Qiang; Zhang, ZhuoYue; Liao, Wei; Xiang, Liangzhong; Yang, Fang; Wang, Z; G, Chen; Tan, Qian; Jiao, Qing; Lu, Guangming

doi:10.3174/ajnr.a3934

Cited by 24 publications

(18 citation statements)

References 39 publications

(62 reference statements)

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“…Seizure recurrence was associated with a less lateralized functional connectivity pattern than seizure freedom, suggesting that high laterality (i.e., stronger functional connectivity in the ictal hemisphere) predicted better outcome. More recently, Xu et al [63] found that compared with poor outcomes, a successful surgical outcome in TLE was associated with larger interhemispheric homotopic functional connectivity differences. Unfortunately, based solely on rsFC, the number of studies investigating the prediction of seizure outcome following anterior temporal lobectomy remains small.…”

Section: Presurgery Functional Connectivity: Added Value As a Predictmentioning

confidence: 98%

Resting-state functional connectivity in epilepsy

Tracy

Doucet²

2015

Current Opinion in Neurology

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The role of rsFC remains limited in most clinical settings, but shows great promise for identifying epileptic circuits and foci, predicting outcomes following surgery, and explaining cognitive deficits and psychiatric symptoms of epilepsy. RsFC has demonstrated that even focal epilepsies constitute a network and brain systems disorder. By providing a tool to both identify and characterize the brain network impact of epileptiform activity, rsFC can make a strong contribution to presurgical algorithms in epilepsy.

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Section: Presurgery Functional Connectivity: Added Value As a Predictmentioning

confidence: 98%

Resting-state functional connectivity in epilepsy

Tracy

Doucet²

2015

Current Opinion in Neurology

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“…Nevertheless, in the last years, new promising predictors of clinical outcomes in refractory TLE have been described based on pre-surgery MRI measures. For instance, using resting-state functional connectivity, Xu et al (2014) found that compared with poor outcomes, a successful surgical outcome in TLE was associated with larger interhemispheric homotopic functional connectivity (FC) differences, pre-surgery. Using structural imaging techniques, recurrent post-surgical seizures have been associated with atrophy in multiple areas such as the thalamus ( Keller et al, 2015a ; Keller et al, 2015b ), temporopolar, and insular cortices, ( Bernhardt et al, 2010 ; Bernhardt et al, 2015 ), along with abnormal white matter tracts emerging from the thalamus ( Keller et al, 2015b ).…”

Section: Introductionmentioning

confidence: 99%

Frontal gray matter abnormalities predict seizure outcome in refractory temporal lobe epilepsy patients

Doucet

Sperling

et al. 2015

NeuroImage: Clinical

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Developing more reliable predictors of seizure outcome following temporal lobe surgery for intractable epilepsy is an important clinical goal. In this context, we investigated patients with refractory temporal lobe epilepsy (TLE) before and after temporal resection. In detail, we explored gray matter (GM) volume change in relation with seizure outcome, using a voxel-based morphometry (VBM) approach. To do so, this study was divided into two parts. The first one involved group analysis of differences in regional GM volume between the groups (good outcome (GO), e.g., no seizures after surgery; poor outcome (PO), e.g., persistent postoperative seizures; and controls, N = 24 in each group), pre- and post-surgery. The second part of the study focused on pre-surgical data only (N = 61), determining whether the degree of GM abnormalities can predict surgical outcomes. For this second step, GM abnormalities were identified, within each lobe, in each patient when compared with an ad hoc sample of age-matched controls. For the first analysis, the results showed larger GM atrophy, mostly in the frontal lobe, in PO patients, relative to both GO patients and controls, pre-surgery. When comparing pre-to-post changes, we found relative GM gains in the GO but not in the PO patients, mostly in the non-resected hemisphere. For the second analysis, only the frontal lobe displayed reliable prediction of seizure outcome. 81% of the patients showing pre-surgical increased GM volume in the frontal lobe became seizure free, post-surgery; while 77% of the patients with pre-surgical reduced frontal GM volume had refractory seizures, post-surgery. A regression analysis revealed that the proportion of voxels with reduced frontal GM volume was a significant predictor of seizure outcome (p = 0.014). Importantly, having less than 1% of the frontal voxels with GM atrophy increased the likelihood of being seizure-free, post-surgery, by seven times. Overall, our results suggest that using pre-surgical GM abnormalities within the frontal lobe is a reliable predictor of seizure outcome post-surgery in TLE. We believe that this frontal GM atrophy captures seizure burden outside the pre-existing ictal temporal lobe, reflecting either the development of epileptogenesis or the loss of a protective, adaptive force helping to control or limit seizures. This study provides evidence of the potential of VBM-based approaches to predict surgical outcomes in refractory TLE candidates.

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“…These findings prompt interests in the physiological mechanisms underlying functional homotopy. In a range of brain disorders, including schizophrenia 23 24 , autism 25 , major depressive disorder 26 , mesial temporal lobe epilepsy 27 , cocaine addiction 28 and functional dyspepsia 29 , alterations in bilateral connectivity have been identified using the VMHC index, suggesting that it is a valid indicator of inter-hemispheric connectivity changes in aging and diseases ( http://fcp-indi.github.io/docs/user/vmhc.html ).…”

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confidence: 99%

Distinct inter-hemispheric dysconnectivity in schizophrenia patients with and without auditory verbal hallucinations

Chang

Cui

et al. 2015

Sci Rep

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Evidence from behavioral, electrophysiological and diffusion-weighted imaging studies suggest that schizophrenia patients suffer from deficiencies in bilateral brain communication, and this disruption may be related to the occurrence of auditory verbal hallucinations (AVH). To increase our understanding of aberrant inter-hemispheric communication in relation to AVH, we recruited two groups of first-episode schizophrenia patients: one group with AVH (N = 18 AVH patients) and one without hallucinations (N = 18 Non-AVH patients), and 20 healthy controls. All participants received T1 structural imaging and resting-state fMRI scanning. We adopted a newly developed index, voxel-mirrored homotopic connectivity (VMHC), to quantitatively describe bilateral functional connectivity. The whole-brain VMHC measure was compared among the three groups and correlation analyses were conducted between symptomology scores and neurological measures. Our findings suggest all patients shared abnormalities in parahippocampus and striatum. Aberrant bilateral connectivity of default mode network (DMN), inferior frontal gyrus and cerebellum only showed in AVH patients, whereas aberrances in superior temporal gyrus and precentral gyrus were specific to Non-AVH patients. Meanwhile, inter-hemispheric connectivity of DMN correlated with patients’ symptomatology scores. This study corroborates that schizophrenia is characterized by inter-hemispheric dysconnectivity, and suggests the localization of such abnormalities may be crucial to whether auditory verbal hallucinations develop.

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Time-Shift Homotopic Connectivity in Mesial Temporal Lobe Epilepsy

Cited by 24 publications

References 39 publications

Resting-state functional connectivity in epilepsy

Resting-state functional connectivity in epilepsy

Frontal gray matter abnormalities predict seizure outcome in refractory temporal lobe epilepsy patients

Distinct inter-hemispheric dysconnectivity in schizophrenia patients with and without auditory verbal hallucinations

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