Time Rules the Efficacy of Immune Checkpoint Inhibitors in Photodynamic Therapy (Adv. Sci. 21/2022)

Chen, Yang; Li, Qing; Chen, Junmeng; Mo, Junfeng; Jin, Ming; Yang, Qianzhan; Rizzello, Loris; Tian, Xiaohe; Li, Luo

doi:10.1002/advs.202270127

Cited by 2 publications

(2 citation statements)

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“…The maturation and activation of T cells lag 3–7 d after PDT. [ 21 ] Thus, we chose the sixth day to detect T cells by FCM after various treatments on days 1, 3, and 5. The gating strategy is shown in Figure S3 (Supporting Information).…”

Section: Resultsmentioning

confidence: 99%

Single‐Component Dual‐Functional Autoboost Strategy by Dual Photodynamic and Cyclooxygenase‐2 Inhibition for Lung Cancer and Spinal Metastasis

Wang,

Lu,

Song

et al. 2024

Advanced Science

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Coloading adjuvant drugs or biomacromolecules with photosensitizers into nanoparticles to enhance the efficiency of photodynamic therapy (PDT) is a common strategy. However, it is difficult to load positively charged photosensitizers and negatively charged adjuvants into the same nanomaterial and further regulate drug release simultaneously. Herein, a single‐component dual‐functional prodrug strategy is reported for tumor treatment specifically activated by tumor microenvironment (TME)‐generated HOCl. A representative prodrug (DHU‐CBA2) is constructed using indomethacin grafted with methylene blue (MB). DHU‐CBA2 exhibited high sensitivity toward HOCl and achieved simultaneous release of dual drugs in vitro and in vivo. DHU‐CBA2 shows effective antitumor activity against lung cancer and spinal metastases via PDT and cyclooxygenase‐2 (COX‐2) inhibition. Mechanistically, PDT induces immunogenic cell death but stimulates the gene encoding COX‐2. Downstream prostaglandins E2 and Indoleamine 2,3 dioxygenase 1 (IDO1) mediate immune escape in the TME, which is rescued by the simultaneous release of indomethacin. DHU‐CBA2 promotes infiltration and function of CD8+ T cells, thus inducing a robust antitumor immune response. This work provides an autoboost strategy for a single‐component dual‐functional prodrug activated by TME‐specific HOCl, thereby achieving favorable tumor treatment via the synergistic therapy of PDT and a COX‐2 inhibitor.

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Section: Resultsmentioning

confidence: 99%

Single‐Component Dual‐Functional Autoboost Strategy by Dual Photodynamic and Cyclooxygenase‐2 Inhibition for Lung Cancer and Spinal Metastasis

Wang,

Lu,

Song

et al. 2024

Advanced Science

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“…Cancer immunotherapy has been recognized as an effective strategy for fighting against cancers, by way of enhancing the immune system of patients to kill tumor cells. Generally, cancer immunotherapies consist of immune checkpoint blockade therapy (ICB), [ 1–3 ] engineered chimeric antigen receptor T‐cell therapy (CAR‐T), and cancer vaccines. [ 4,5 ] Among them, cancer vaccines hold great promise thanks to their advantages of high safety, low costs and satisfactory surgical outcome.…”

Section: Introductionmentioning

confidence: 99%

Carbon Dots and Tumor Antigen Conjugates as Nanovaccines for Elevated Cancer Immunotherapy

Liu

Xie

Zheng

2023

Small

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Cancer immunotherapy has become one of the current research hotspots. However, the deficiencies including restricted immunogenicity, insufficient antigen presentation, and low responsive rate limited their therapeutic applications. Own to the small size and excellent biocompatibility, carbon dots (CDs) can serve as nanovectors to improve the efficacy of cancer immunotherapy. Herein, a tumor antigen‐based nanovaccines (GMal+B16F10‐Ag and GMal+CT26‐Ag) by the conjugation of CDs with the tumor cell‐derived antigens (B16F10‐Ag and CT26‐Ag) is constructed. These nanovaccines can be effectively taken up by dendritic cells (DC2.4), promote DC cell maturation, cross‐present the antigen to T cells, specifically target B16F10 melanoma or CT26 colon cancers, and inhibit tumor growth distinctly. This work illustrates the promise of CDs acting as versatile carriers for antigen delivery to achieve the optimal immunotherapeutic outcomes.

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Time Rules the Efficacy of Immune Checkpoint Inhibitors in Photodynamic Therapy (Adv. Sci. 21/2022)

Cited by 2 publications

References 0 publications

Single‐Component Dual‐Functional Autoboost Strategy by Dual Photodynamic and Cyclooxygenase‐2 Inhibition for Lung Cancer and Spinal Metastasis

Single‐Component Dual‐Functional Autoboost Strategy by Dual Photodynamic and Cyclooxygenase‐2 Inhibition for Lung Cancer and Spinal Metastasis

Carbon Dots and Tumor Antigen Conjugates as Nanovaccines for Elevated Cancer Immunotherapy

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