Time-restricted feeding mitigates high-fat diet-enhanced mammary tumorigenesis in MMTV-PyMT mice

Sundaram, Shanthy; Yan, Lin

doi:10.1016/j.nutres.2018.07.014

Cited by 38 publications

(43 citation statements)

References 46 publications

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“…Feeding weanling mice a high-fat diet disrupts daily oscillations of energy expenditure (28), increases body adiposity (28), and enhances mammary tumorigenesis in a mouse mammary tumor virus-polyomavirus middle T-antigen (MMTV-PyMT) model of breast cancer (29). Time-restricted feeding of weanling mice during the dark phase reduces the highfat diet-enhanced mammary tumorigenesis (30). Time-restricted feeding is an effective tool in circadian research that restores daily Abbreviations: Bmal1, aryl hydrocarbon receptor nuclear translocator-like protein 1; Clock, circadian locomotor output cycles kaput; Cry.…”

Section: Introductionmentioning

confidence: 99%

High-Fat Diet Alters Circadian Rhythms in Mammary Glands of Pubertal Mice

2020

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Childhood obesity in girls is associated with early puberty and menarche. Breast tissue exhibits circadian rhythms. These rhythms may be altered by environmental factors. We hypothesized that a high-fat diet (HFD) disrupts circadian rhythms in pubertal mammary glands. Weanling female C57BL/6 mice were fed the standard AIN93G diet or a HFD (providing 16% or 45% of energy from soybean oil) for 3 weeks. Mammary glands were harvested from 6-week-old mice every 4 h on Zeitgeber time over a 48-h period; rhythmic expressions of circadian genes and genes encoding estrogen receptor and progesterone receptor were analyzed by using the Cosinor model. HFD, compared to AIN93G diet, altered diurnal oscillations of circadian genes in pubertal mammary glands. These included changes in amplitude of Per2, Cry1 (reduced), Clock, Rev-erbα, and Per1 (elevated), a delay in acrophase (the hour at which the rhythm peaks) of Bmal1 by 2.2 h, and changes in mesor (the mean of the rhythm from peak to trough) of Bmal1, Per2, Cry1 (reduced), Rev-rebα, and Per1 (elevated). Furthermore, HFD altered diurnal expression of estrogen receptor and progesterone receptor at both mRNA and protein levels. These findings indicate that HFD alters circadian regulation in pubertal mammary glands, which may contribute to the disturbance of hormonal homeostasis and lead to early development and growth of mammary glands in pubertal mice.

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Section: Introductionmentioning

confidence: 99%

High-Fat Diet Alters Circadian Rhythms in Mammary Glands of Pubertal Mice

2020

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“…Interestingly, epidemiological studies in women have suggested that prolonged nightly fasting may decrease the risk of breast cancer [46] and breast cancer recurrence [24]. Most recently, exposure to TRF for 8 weeks was found to mitigate high-fat diet-enhanced mammary tumorigenesis in the MMTV-PyMT mouse model [25].…”

Section: Discussionmentioning

confidence: 99%

“…A retrospective epidemiological study in humans reported a positive correlation between protection from breast cancer risk and duration of overnight fasting period [24]. In a more recent report, exposure to TRF for 8 weeks was found to mitigate high-fat diet-enhanced mammary tumorigenesis in the mouse mammary tumor virus-polyoma middle tumor-antigen (MMTV-PyMT) model [25]. Based on these premises, the present investigation analyzes the effect of long term TRF on the emergence of the age-associated, neoplastic-prone tissue microenvironment in rat liver.…”

Section: Introductionmentioning

confidence: 99%

Time-restricted feeding delays the emergence of the age-associated, neoplastic-prone tissue landscape

Serra

Marongiu

Pisu

et al. 2019

Aging

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Aging increases the risk of cancer partly through alterations in the tissue microenvironment. Time-restricted feeding (TRF) is being proposed as an effective strategy to delay biological aging. In the present studies, we assessed the effect of long-term exposure to TRF on the emergence of the age-associated, neoplastic-prone tissue landscape. Animals were exposed to either ad libitum feeding (ALF) or TRF for 18 months and then transplanted with hepatocytes isolated from pre-neoplastic nodules. Both groups were continued ALF and the growth of transplanted cells was evaluated 3 months later. A significant decrease in frequency of larger size clusters of pre-neoplastic hepatocytes was seen in TRF-exposed group compared to controls. Furthermore, TRF modified several parameters related to both liver and systemic aging towards the persistence of a younger phenotype, including a decrease in liver cell senescence, diminished fat accumulation and up-regulation of SIRT1 in the liver, down-regulation of plasma IGF-1, decreased levels of plasma lipoproteins and up-regulation of hippocampal brain-derived growth factor (BDNF).These results indicate that TRF was able to delay the onset of the neoplastic-prone tissue landscape typical of aging. To our knowledge, this is the first investigation to describe a direct beneficial effect of TRF on early phases of carcinogenesis.

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“…A recent literature review of pre-clinical models by Lv et al (13) reports that intermittent fasting approaches were significantly preventive against cancer in ~60% of animal studies. Both the fasting-mimicking diet and time-restricted feeding have been associated with improved cancer treatment outcomes in all animal models of cancer tested thus far, through immunologic and metabolic mechanisms similar to those induced by CR (31–34). In particular, these two interventions have improved responses to anthracycline-based chemotherapies, leading to decreased tumor outgrowth in murine models of sarcoma, lung, colon, melanoma, and breast cancer (31, 32).…”

Section: Intermittent Fastingmentioning

confidence: 99%

Targeting Glucose Metabolism to Enhance Immunotherapy: Emerging Evidence on Intermittent Fasting and Calorie Restriction Mimetics

et al. 2019

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There is growing interest in harnessing lifestyle and pharmaceutical interventions to boost immune function, reduce tumor growth, and improve cancer treatment efficacy while reducing treatment toxicity. Interventions targeting glucose metabolism are particularly promising, as they have the potential to directly inhibit tumor cell proliferation. However, because anti-tumor immune effector cells also rely on glycolysis to sustain their clonal expansion and function, it remains unclear whether glucose-modulating therapies will support or hinder anti-tumor immunity. In this perspective, we summarize a growing body of literature that evaluates the effects of intermittent fasting, calorie restriction mimetics, and anti-hyperglycemic agents on anti-tumor immunity and immunotherapy outcomes. Based on the limited data currently available, we contend that additional pre-clinical studies and clinical trials are warranted to address the effects of co-administration of anti-hyperglycemic agents or glucose-lowering lifestyle modifications on anti-tumor immunity and cancer treatment outcomes. We stress that there is currently insufficient evidence to provide recommendations regarding these interventions to cancer patients undergoing immunotherapy. However, if found to be safe and effective in clinical trials, interventions targeting glucose metabolism could act as low-cost combinatorial adjuvants for cancer patients receiving immune checkpoint blockade or other immunotherapies.

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Time-restricted feeding mitigates high-fat diet-enhanced mammary tumorigenesis in MMTV-PyMT mice

Cited by 38 publications

References 46 publications

High-Fat Diet Alters Circadian Rhythms in Mammary Glands of Pubertal Mice

High-Fat Diet Alters Circadian Rhythms in Mammary Glands of Pubertal Mice

Time-restricted feeding delays the emergence of the age-associated, neoplastic-prone tissue landscape

Targeting Glucose Metabolism to Enhance Immunotherapy: Emerging Evidence on Intermittent Fasting and Calorie Restriction Mimetics

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