Time restricted feeding is associated with poor performance in specific cognitive domains of Suburb-Dwelling older Chinese

Abstract

The purpose of this study was to investigate the association between time restricted feeding (TRF) and different areas of cognitive function in the elderly in Chinese communities. This study consisted of 1353 community-dwelling Chinese older adults aged 60 years and older in Chongming area, Shanghai (563 males; the mean age, 73.38 ± 6.16 years). Mild cognitive impairment (MCI) and six different cognitive domains was assessed by the Chinese-version of Mini Mental State Examination (MMSE). Recording the eating time of each meal through oral inquiry to calculate the time window between the first meal and the last meal of the average day. Participants with an eating time window duration of more than 10 h were then identified, as well as those with eating time restricted to less than 10 h (TRF). Our study found that TRF may be associated with a higher incidence rate of cognitive impairment. TRF only limited the eating time window and did not change the frequency of participants' dietary intake. We used a linear regression model to study the association of TRF with cognitive function. After adjusting for confounding variables, the results showed that TRF was related to MMSE score (P < 0.001), "Orientation to place" (P < 0.001) and "Attention/calculation" (P < 0.001) functions. Among Chinese older community-dwellers, TRF was associated with a higher prevalence of CI and negatively correlated with the "Orientation to place" and "attention/calculation" functions.

Effect of time-restricted eating and intermittent fasting on cognitive function and mental health in older adults: A systematic review

“…The analysis also pointed out that older age, hypertension, and stroke were positively associated with participation in the TRE group. Moreover, the results indicated that TRE was negatively related to the Mini-Mental State Examination (MMSE) score (P < 0.001) in addition to the specific cognitive functions mentioned earlier ( Li et al, 2023 ).…”

“… Physically active individuals showed improvement in executive function, attention, inhibition, associative memory, and recognition memory during Ramadan, while sedentary individuals experienced a decline in associative learning performance. Li et al (2023) , China N = 1353, Mean age: 73.38 ± 6.16 years, 563 men and 790 women Cross-sectional study 10-h TRE vs. less than 10 h TRE Chinese-version of Mini Mental State Examination TRE was associated with a higher prevalence of cognitive impairment in the domains of orientation to place and attention/calculation. Hussin et al (2013) , Malaysia N = 31 men, Mean age: 59.7, SD: 6.3 Randomized controlled trial (RCT) Calorie-restricted dietary regime with intermittent fasting during a 3-month period The Beck Depression Inventory-II and Geriatric Depression Scale-15 were measured at baseline, as well as at weeks 6 and 12 of the study.…”

“…Furthermore, Li et al (2023) reported that a 10-hour TRE was associated with impairment in orientation to place and attention/calculation. After adjusting for covariates, including age, male gender, BMI, Instrumental Activities of Daily Living (IADL), illiteracy, widowhood, living alone, farming occupation, smoking and drinking habits, night-time feeding, International Physical Activity Questionnaire (IPAQ) score, type-2 diabetes, hypertension, dyslipidemia, stroke, heart disease, and cancer, The study revealed that TRE had a negative impact on the “Orientation to place” (P < 0.001) and “Attention/calculation” (P < 0.001) functions within six cognitive domains..…”

The Role of Intermittent Fasting and Dieting on Cognition in Adult Population: A Systematic Review of the Randomized Controlled Trials

“…Additionally, IF in males >50 years of age showed increased weight loss compared to females, suggesting that gender and age differences are important to consider while assessing IF [26]. A study conducted by Li et al [27] found that older individuals (>70 years old) with pre-existing MCIs showed worsening orientation to place and attention after IF. as a result, caution is necessary for older adults with pre-existing cognitive impairments.…”

Nutrition and cognitive function in the elderly population

“…The results were completely divergent. While the TRF strategy produced favourable results in the Italian population, studies conducted in China have even indicated a higher incidence of progression of cognitive impairment (Currenti et al, 2021;Li et al, 2023).…”