Time-restricted feeding improves adaptation to chronically alternating light-dark cycles

Schilperoort, Maaike; Berg, Rosa van den; Dollé, Martijn E.T.; Oostrom, Conny Th.M. van; Wagner, Karina; Tambyrajah, Lauren L.; Wackers, Paul; Deboer, Tom; Hulsegge, Gerben; Proper, Karin I.; Steeg, Harry van; Roenneberg, Till; Biermasz, Nienke R.; Rensen, Patrick C.N.; Kooijman, Sander; Kerkhof, Linda W M van

doi:10.1038/s41598-019-44398-7

Cited by 19 publications

(21 citation statements)

References 44 publications

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“…Furthermore, dark-phase TRF normalized clock gene expression in diabetic mice of which the daily rhythm in locomotor was dampened and clock gene rhythms were shifted (84). TRF can help adapt to a changing light-dark schedule, hence providing a promising strategy to expedite adaptation of the circadian system (85) or to prevent shifting during shift-work.…”

Section: Time-restricted Feeding (Trf)mentioning

confidence: 99%

The Circadian Clock, Shift Work, and Tissue-Specific Insulin Resistance

2020

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Obesity and type 2 diabetes (T2D) have become a global health concern. The prevalence of obesity and T2D is significantly higher in shift workers compared to people working regular hours. An accepted hypothesis is that the increased risk for metabolic health problems arises from aberrantly timed eating behavior, that is, eating out of synchrony with the biological clock. The biological clock is part of the internal circadian timing system, which controls not only the sleep/wake and feeding/fasting cycle, but also many metabolic processes in the body, including the timing of our eating behavior, and processes involved in glucose homeostasis. Rodent studies have shown that eating out of phase with the endogenous clock results in desynchronization between rhythms of the central and peripheral clock systems and between rhythms of different tissue clocks (eg, liver and muscle clock). Glucose homeostasis is a complex process that involves multiple organs. In the healthiest situation, functional rhythms of these organs are synchronized. We hypothesize that desynchronization between different metabolically active organs contributes to alterations in glucose homeostasis. Here we summarize the most recent information on desynchronization between organs due to shift work and shifted food intake patterns and introduce the concept of phenotypic flexibility, a validated test to assess the contribution of each organ to insulin resistance (IR) in humans. We propose this test as a way to provide further insight into the possible desynchronization between tissue clocks. Because different types of IR benefit from different therapeutic approaches, we also describe different chronotherapeutic strategies to promote synchrony within and between metabolically active organs.

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Section: Time-restricted Feeding (Trf)mentioning

confidence: 99%

The Circadian Clock, Shift Work, and Tissue-Specific Insulin Resistance

2020

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“…The beneficial effects of TRF on mood regulation may be related to the entraining properties of food in phase with activity which prevents circadian disruption and enforces circadian function (Salgado-Delgado et al, 2010Schilperoort et al, 2019). Previous Other studies have suggested that the beneficial effects of TRF may not only be related to the reestablishment of the molecular circadian clock function on metabolic related organs, since TRF drive the rhythmic expression certain genes even in mutant mice (Atger et al, 2015;Vollmers et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

“…The beneficial effects of TRF on mood regulation may be related to the entraining properties of food in phase with activity which prevents circadian disruption and enforces circadian function (Salgado‐Delgado et al., 2010, 2013; Schilperoort et al., 2019). Previous studies demonstrated that food elicited signals entrain brain areas involved in metabolic function (Ramirez‐Plascencia et al., 2017) as well as areas related with mood regulation (Angeles‐Castellanos et al., 2008; Verwey & Amir, 2009).…”

Section: Discussionmentioning

confidence: 99%

“…Importantly, time-restricted feeding (TRF) to the night phase restored circadian rhythmicity, metabolic function, and the inflammatory response to control levels, while food restricted to the rest phase aggravated the condition (Guerrero-Vargas et al, 2015;Salgado-Delgado et al, 2010). The beneficial effects of TRF in phase with the activity phase on the circadian system and metabolism were also described in experimental models of jet lag (Angeles-Castellanos et al, 2011;Schilperoort et al, 2019) and in rodents fed with a high fat diet (Hatori et al, 2012).…”

Section: Significancementioning

confidence: 99%

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Time‐restricted feeding prevents depressive‐like and anxiety‐like behaviors in male rats exposed to an experimental model of shift‐work

Guerrero‐Vargas¹,

Zárate‐Mozo²,

Guzmán-Ruiz

et al. 2020

J of Neuroscience Research

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Individuals who regularly shift their sleep timing, like night and/or shift-workers suffer from circadian desynchrony and are at risk of developing cardiometabolic diseases and cancer. Also, shift-work is are suggested to be a risk factor for the development of mood disorders such as the burn out syndrome, anxiety, and depression. Experimental and clinical studies provide evidence that food intake restricted to the normal activity phase is a potent synchronizer for the circadian system and can prevent the detrimental health effects associated with circadian disruption. Here, we explored whether adult male Wistar rats exposed to an experimental model of shift-work (W-AL) developed depressive and/or anxiety-like behaviors and whether this was associated with neuroinflammation in brain areas involved with mood regulation. We also tested whether time-restricted feeding (TRF) to the active phase could ameliorate circadian disruption and therefore would prevent depressive and anxiety-like behaviors as well as neuroinflammation. In male Wistar rats, W-AL induced depressive-like behavior characterized by hypoactivity and anhedonia and induced increased anxiety-like behavior in the open field test. This was associated with increased number of glial fibrillary acidic protein and IBA-1-positive cells in the prefrontal cortex and basolateral amygdala. Moreover W-AL caused morphological changes in the microglia in the CA3 area of the hippocampus indicating microglial activation. Importantly, TRF prevented behavioral changes and decreased neuroinflammation markers in the brain. Present results add up evidence about the importance that TRF in synchrony with the light-dark cycle can prevent neuroinflammation leading to healthy mood states in spite of circadian disruptive conditions.

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“…Beginning with preclinical research, studies of mice have shown that restricting food access to the dark period (the active phase for these nocturnal animals) may protect against the obesogenic effects of repeated 6-h advances in the LD cycle (48). In addition, restricting food access to the active phase may also accelerate adaptation of circadian rhythms in core body temperature and locomotor activity to repeated 12-h changes in LD cycles (49). These findings imply that people would better cope with rotating shift work if they fixed their eating to the daytime, which is somewhat counterintuitive given that fixing eating time during shifting LD cycles might be expected to uncouple circadian rhythms between the suprachiasmatic nucleus and peripheral clocks.…”

Section: Diet Timing In Shift Workersmentioning

confidence: 99%

The Future of Shift Work: Circadian Biology Meets Personalised Medicine and Behavioural Science

Potter

Wood

2020

Front. Nutr.

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Shift work is commonplace in modern societies, and shift workers are predisposed to the development of numerous chronic diseases. Disruptions to the circadian systems of shift workers are considered important contributors to the biological dysfunction these people frequently experience. Because of this, understanding how to alter shift work and zeitgeber (time cue) schedules to enhance circadian system function is likely to be key to improving the health of shift workers. While light exposure is the most important zeitgeber for the central clock in the circadian system, diet and exercise are plausible zeitgebers for circadian clocks in many tissues. We know little about how different zeitgebers interact and how to tailor zeitgeber schedules to the needs of individuals; however, in this review we share some guidelines to help shift workers adapt to their work schedules based on our current understanding of circadian biology. We focus in particular on the importance of diet timing and composition. Going forward, developments in phenotyping and "envirotyping" methods may be important to understanding how to optimise shift work. Non-invasive, multimodal, comprehensive phenotyping using multiple sources of time-stamped data may yield insights that are critical to the care of shift workers. Finally, the impact of these advances will be reduced without modifications to work environments to make it easier for shift workers to engage in behaviours conducive to their health. Integrating findings from behavioural science and ergonomics may help shift workers make healthier choices, thereby amplifying the beneficial effects of improved lifestyle prescriptions for these people.

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Time-restricted feeding improves adaptation to chronically alternating light-dark cycles

Cited by 19 publications

References 44 publications

The Circadian Clock, Shift Work, and Tissue-Specific Insulin Resistance

The Circadian Clock, Shift Work, and Tissue-Specific Insulin Resistance

Time‐restricted feeding prevents depressive‐like and anxiety‐like behaviors in male rats exposed to an experimental model of shift‐work

The Future of Shift Work: Circadian Biology Meets Personalised Medicine and Behavioural Science

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