Time-restricted eating improves glycemic control and dampens energy-consuming pathways in human adipose tissue

Zhao, Lijun; Hutchison, Amy T.; Liu, Bo; Yates, C; Teong, Xiao Tong; Wittert, Gary; Thompson, Campbell; Nguyen, Leanne; Au, John; Manoogian, Emily N. C.; Le, Hiep D.; Williams, April; Panda, Satchidananda; Banks, Siobhan; Heilbronn, Leonie K.

doi:10.1016/j.nut.2021.111583

Cited by 25 publications

(42 citation statements)

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“…Time-of-day nutrient digestion has also proved to be important for rhythmicity in metabolic gene expression in other tissues. Time restricted feeding (TRF) under both chow and high fat diet conditions can boost the amplitude of rhythms in hepatic gene expression and in serum metabolite abundance [ 55 , 92 , 93 , 94 , 95 , 96 ], while restricting feeding to the rest phase instead of the active phase puts time-keeping between peripheral clocks and the central pacemaker out of sync [ 97 ]. Restricted feeding to the rest phase also destroys the temporal pattern of circulating bile acids in the serum.…”

Section: Nutrients As Zeitgebers In Adipose Tissuementioning

confidence: 99%

Nutrients and the Circadian Clock: A Partnership Controlling Adipose Tissue Function and Health

Ribas‐Latre

Eckel‐Mahan

2022

Nutrients

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White adipose tissue (WAT) is a metabolic organ with flexibility to retract and expand based on energy storage and utilization needs, processes that are driven via the coordination of different cells within adipose tissue. WAT is comprised of mature adipocytes (MA) and cells of the stromal vascular cell fraction (SVF), which include adipose progenitor cells (APCs), adipose endothelial cells (AEC) and infiltrating immune cells. APCs have the ability to proliferate and undergo adipogenesis to form MA, the main constituents of WAT being predominantly composed of white, triglyceride-storing adipocytes with unilocular lipid droplets. While adiposity and adipose tissue health are controlled by diet and aging, the endogenous circadian (24-h) biological clock of the body is highly active in adipose tissue, from adipocyte progenitor cells to mature adipocytes, and may play a unique role in adipose tissue health and function. To some extent, 24-h rhythms in adipose tissue rely on rhythmic energy intake, but individual circadian clock proteins are also thought to be important for healthy fat. Here we discuss how and why the clock might be so important in this metabolic depot, and how temporal and qualitative aspects of energy intake play important roles in maintaining healthy fat throughout aging.

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Section: Nutrients As Zeitgebers In Adipose Tissuementioning

confidence: 99%

Nutrients and the Circadian Clock: A Partnership Controlling Adipose Tissue Function and Health

Ribas‐Latre

Eckel‐Mahan

2022

Nutrients

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“…For both groups, the variations in fatty acid oxidation correlated with caloric intake ( Fig.5-K, L ), but was independent from body weight and lean mass which are comparable between the two genotypes ( Fig.5-C, D ), indicating that loss of function of Ankk1 influences peripheral nutrient utilization. Interestingly, fatty acid oxidation mostly decreased during the light phase ( Fig.5-L ), which might indicate a dissociation between circadian-entrained-rhythm and whole body fatty acid oxidation 62,63 . Importantly, when tested on a binge eating paradigm with HFHS, a test aiming at quantifying uncontrolled voracious eating, Ankk1 Δ-NAc mice showed enhanced food consumption during the binge time ( Supp.4-E ).…”

Section: Resultsmentioning

confidence: 94%

“…Interestingly, fatty acid oxidation mostly decreased during the light phase (Fig. 5-L), which might indicate a dissociation between circadian-entrained-rhythm and whole body fatty acid oxidation 62,63 . Importantly, when tested on a binge eating paradigm with HFHS, a test aiming at quantifying uncontrolled voracious eating, Ankk1 ∆-NAc mice showed enhanced food consumption during the binge time (Supp.4-E).…”

Section: Striatal Deletion Of Ankk1 Alters Energy Homeostasismentioning

confidence: 95%

The addiction-susceptibility TaqIA/Ankyrin repeat and kinase domain containing 1 kinase (ANKK1) controls reward and metabolism through dopamine receptor type 2 (DR2)-expressing neurons

Montalban

Walle

Castel

et al. 2022

Preprint

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Significant evidence highlights the importance of genetic variants in the development of psychiatric and metabolic conditions. Among these, the Taq1A polymorphism is one of the most commonly studied in psychiatry. TaqIA is located in the gene that codes for the Ankyrin repeat and kinase domain containing 1 kinase (ANKK1) near the dopamine D2 dopamine receptor (DR2) gene. Depending on race it affects 30 to 80% of the population and its homozygous expression of the A1 allele correlates with a 30 to 40% reduction of striatal DR2, a typical feature of addiction, over-eating and other psychiatric pathologies. The mechanisms by which the variant influences dopamine signaling and behavior is unknown. Here we used transgenic and viral-mediated strategies to reveal the role of ANKK1 in the regulation of activity and functions of the striatum. We found that Ankk1 is preferentially enriched in striatal DR2 expressing neurons and that Ankk1 loss-of-function in dorsal and ventral striatum leads to alteration in learning, impulsive, and flexible behaviors resembling the endophenotypes described in A1 carriers. We also observed an unsuspected role of ANKK1 in striatal DR2-expressing neurons in the ventral striatum in the regulation of energy homeostasis and documented differential nutrient partitioning in humans with versus without the A1 allele. Overall, our data demonstrate that the Ankk1 gene is necessary for the integrity of striatal functions and reveal a new role for ANKK1 in the regulation of body metabolism.

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“…While a singular eating window length that is optimal for health has not yet been identified, previous trials have shown that a longer eating window of 12 h does not yield the same health benefits ( 42 ), while a shorter eating window of 4 h doesn't show additional benefits compared to 6-h TRE ( 1 ). Given the current body of literature, eating windows ranging from 6 to 10 h seems to be ideal as they yield benefits while allowing participants to eat within a reasonable time frame ( 5 , 6 , 43 ). Moreover, some studies have shown that an earlier window may be more beneficial than an eating window that ends later in the day ( 9 , 44 ), yet many benefits are still seen from TRE studies with a later eating window ( 45 ).…”

Section: Suggestions For Future Studiesmentioning

confidence: 99%

Barriers to adherence in time-restricted eating clinical trials: An early preliminary review

et al. 2023

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Time-restricted eating (TRE) has shown potential benefits in optimizing the body's circadian rhythms and improving cardiometabolic health. However, as with all dietary interventions, a participant's ability to adhere to the protocol may be largely influenced by a variety of lifestyle factors. In TRE trials that reported participants' rates of adherence, the percentage of total days with successful adherence to TRE ranged from 47% to 95%. The purpose of this review is to (1) summarize findings of lifestyle factors affecting adherence to TRE clinical trials outside of the lab, and (2) explore a recommended set of behavioral intervention strategies for the application of TRE. A literature search on Pubmed was conducted to identify clinical TRE studies from 1988 to October 5, 2022, that investigated TRE as a dietary intervention. 21 studies included daily self-monitoring of adherence, though only 10 studies reported a combination of family, social, work, and miscellaneous barriers. To maximize participant adherence to TRE and increase the reliability of TRE clinical trials, future studies should monitor adherence, assess potential barriers, and consider incorporating a combination of behavioral intervention strategies in TRE protocols.

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Time-restricted eating improves glycemic control and dampens energy-consuming pathways in human adipose tissue

Cited by 25 publications

References 50 publications

Nutrients and the Circadian Clock: A Partnership Controlling Adipose Tissue Function and Health

Nutrients and the Circadian Clock: A Partnership Controlling Adipose Tissue Function and Health

The addiction-susceptibility TaqIA/Ankyrin repeat and kinase domain containing 1 kinase (ANKK1) controls reward and metabolism through dopamine receptor type 2 (DR2)-expressing neurons

Barriers to adherence in time-restricted eating clinical trials: An early preliminary review

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