Abstract:<p>X-ray phase contrast imaging (XPCI) of anti-solvent
crystallization of lovastatin from an acetone/water solution was carried out in
a concentric flow mixing device, using water as the anti-solvent. Spinodal
decomposition of the solution is observed to give rise to ‘oiled out’ phases
that undergo heterogeneous nucleation at the interface with the flowing
solution. Heterogeneous nucleation is also observed on the walls of the reactor
walls in the form of what appears to be Stranski–Krastanov
growth of p… Show more
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