Time-Resolved Fourier Transform Infrared Spectroscopic Imaging

Bhargava, Rohit; Levin, Ira W.

doi:10.1366/00037020360625880

Cited by 45 publications

(32 citation statements)

References 54 publications

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“…Electric field was also used to induce the orientation of ferroelectric liquid crystals, and the polarization angle dependence was used to construct 2D IR spectra [187]. A repetitive electrical field was used for the 2D IR correlation study of time-resolved IR imaging of polymer-dispersed liquid crystals with both spatial and temporal resolution [192]. Interesting but rather unusual form of perturbation for 2D analysis was reported by Petibois and Déléris [195].…”

Section: Other Perturbation Methodsmentioning

confidence: 98%

“…An image from scanning near-field optical microscopy (SNOM) was used for 2D analysis, and parallel and perpendicular components were separated by using 2D correlation spectra. Bhargava and Levin [192] reported the 2D IR correlation of time-resolved IR imaging with both spatial and temporal resolution. Polymer-dispersed liquid crystals (PDLC) under a repetitive electrical field were also studied.…”

Section: Saptial Imagesmentioning

confidence: 99%

See 1 more Smart Citation

Advances in two-dimensional correlation spectroscopy

Noda

2004

Vibrational Spectroscopy

234

149

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Section: Other Perturbation Methodsmentioning

confidence: 98%

Section: Saptial Imagesmentioning

confidence: 99%

Advances in two-dimensional correlation spectroscopy

Noda

2004

Vibrational Spectroscopy

234

149

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“…33 In such experiments, a step scan spectrometer is used to record images at specific time points of a repeating event. Using this technique, time resolved FT-IR images 34 or linear images 35 can be achieved with millisecond temporal resolution. However, this approach relies on reproducing identical events and requires a precise timing of the measurement process.…”

Section: Resultsmentioning

confidence: 99%

Generation of Chemical Movies: FT-IR Spectroscopic Imaging of Segmented Flows

Chan¹,

Niu

deMello

et al. 2011

Anal. Chem.

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We have previously demonstrated that FTIR spectroscopic imaging can be used as a powerful, label-free detection method for studying laminar flows. However, to date, the speed of image acquisition has been too slow for the efficient detection of moving droplets within segmented flow systems. In this paper, we demonstrate the extraction of fast FTIR images with acquisition times of 50 ms. This approach allows efficient interrogation of segmented flow systems where aqueous droplets move at a speed of 2.5 mm/s. Consecutive FTIR images separated by 120 ms intervals allow the generation of chemical movies at eight frames per second. The technique has been applied to the study of microfluidic systems containing moving droplets of water in oil and droplets of protein solution in oil. The presented work demonstrates the feasibility of using FTIR imaging to study dynamic systems with sub-second temporal resolution.

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“…However, if an event is reproducible and triggerable, it can be synchronized at each step of the mirror retardation, with faster time resolutions achievable using the step-scan mode. Time resolutions in the millisecond timescales have been demonstrated by Bhargava and Levin [97], who suggest that with the appropriate setup, time resolutions in the microsecond timescale are feasible.…”

Section: Ir Imaging Speed and Performance Considerationsmentioning

confidence: 99%

FT‐IR Imaging Hardware

Sellors

Hoult

Crocombe

et al. 2010

Raman, Infrared, and Near‐Infrared Chemical Imaging

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The combination of IR spectroscopy with visible microscopy has been used in a wide range of analytical applications for more than 20 years. More recently, however, IR microspectroscopy has benefited from developments in IR detector arrays leading to a marked growth in FT-IR imaging technologies and applications. It is now a fairly simple task to obtain a high-quality IR spectrum from a sample region of around 20 mm in matter of seconds, and the ability to collect full IR images containing hundreds of thousands of pixels, where every image pixel contains a full range IR spectrum, is now available in many hundreds of laboratories worldwide. IR imaging hardware is not yet mature, but despite this, with today's state-of-the-art FT-IR imaging systems, the analysis time for many applications is limited not by the speed at which quality images are obtained, but by the data analysis or sample preparation techniques at the disposal of the operator.Progress in commercial FT-IR imaging hardware development comes from various drivers, but two are particularly relevant: (a) the high popularity of single point IR microscopy systems that has fuelled the interest in technology and applications utilizing more rapid methods of data acquisition and (b) the development of multichannel array detectors that operate in the mid-infrared region for nonspectroscopic applications. These are fundamental to both the understanding of current FT-IR imaging technologies and probable developments in the near future. Developments in IR Microscopy and Imaging SystemsInterest in obtaining IR spectra from small samples goes back to over 60 years; for example, a reported study of the structure of penicillin by Thomson [1] in the late 1940s used a prismbased dispersive spectrometer coupled with a beam condenser/microscope system. A commercial IR microscope system described in 1953 by Coates et al. [2] demonstrated quite respectable IR spectra from single fiber samples of less than 20 mm in diameter, recorded with 15 min scan times, and contained some design attributes that are still present in today's systems. However, it was not until early 1980s when the rapid uptake of commercial FT-IR systems and applications such as semiconductor microanalysis provided both the applications and technology interest to spur the growth in IR microspectroscopy. Today, all major manufacturers of laboratory FT-IR spectrometers include IR microscopes, some with automated point mapping systems, as well as imaging systems in their product portfolios.Early (1980s) FT-IR microscope systems were mostly bolt-on accessories derived from optical microscope frames that were modified to support the collection of IR spectra from selected regions of interest (ROI). Later, systems were Raman, Infrared, and Near-Infrared Chemical Imaging Edited by Slobodan Š ašić and Yukihiro Ozaki

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Time-Resolved Fourier Transform Infrared Spectroscopic Imaging

Cited by 45 publications

References 54 publications

Advances in two-dimensional correlation spectroscopy

Advances in two-dimensional correlation spectroscopy

Generation of Chemical Movies: FT-IR Spectroscopic Imaging of Segmented Flows

FT‐IR Imaging Hardware

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