Time‐Resolved Evaluation of L‐Dopa Metabolism in Bacteria‐Host Symbiotic System and the Effect on Parkinson's Molecular Pathology
Doyeon Kim,
Tin Tin Manh Nguyen,
Yechan Moon
et al.
Abstract:The gut microbiome influences drug metabolism and therapeutic efficacy. Still, the lack of a general label‐free approach for monitoring bacterial or host metabolic contribution hampers deeper insights. Here, a 2D nuclear magnetic resonance (NMR) approach is introduced that enables real‐time monitoring of the metabolism of Levodopa (L‐dopa), an anti‐Parkinson drug, in both live bacteria and bacteria‐host (Caenorhabditis elegans) symbiotic systems. The quantitative method reveals that discrete Enterococcus faeca… Show more
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