Time‐resolved angiography with stochastic trajectories for dynamic contrast‐enhanced MRI in head and neck cancer: Are pharmacokinetic parameters affected?

Panek, Rafał; Schmidt, Marianne; Borri, Marco; Koh, Dow‐Mu; Riddell, Angela M.; Welsh, Liam; Dunlop, A.; Powell, Ceri; Bhide, Shreerang A.; Nutting, Christopher M.; Harrington, Kevin; Newbold, Kate; Leach, Martin O.

doi:10.1118/1.4964795

Cited by 4 publications

(1 citation statement)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, DCE acquisition protocols always aim to have the best trade-off between spatial and temporal resolution. Modern protocols allow for rapid (ie, approximately every 3 seconds) 3-dimensional (3D) imaging 19 , 20 . Furthermore, DCE MRI often uses T1-weighted sequences to study contrast enhancement, which are considered one of the best image types for depicting head and neck tumors (21) .…”

Section: Introductionmentioning

confidence: 99%

MRI-based Assessment of 3D Intrafractional Motion of Head and Neck Cancer for Radiation Therapy

Gurney‐Champion

McQuaid

Dunlop

et al. 2018

International Journal of Radiation Oncology*Biology*Physics

Self Cite

View full text Add to dashboard Cite

PurposeTo determine the 3-dimensional (3D) intrafractional motion of head and neck squamous cell carcinoma (HNSCC).Methods and MaterialsDynamic contrast-enhanced magnetic resonance images from 56 patients with HNSCC in the treatment position were analyzed. Dynamic contrast-enhanced magnetic resonance imaging consisted of 3D images acquired every 2.9 seconds for 4 minutes 50 seconds. Intrafractional tumor motion was studied in the 3 minutes 43 seconds of images obtained after initial contrast enhancement. To assess tumor motion, rigid registration (translations only) was performed using a region of interest (ROI) mask around the tumor. The results were compared with bulk body motion from registration to all voxels. Motion was split into systematic motion and random motion. Correlations between the tumor site and random motion were tested. The within-subject coefficient of variation was determined from 8 patients with repeated baseline measures. Random motion was also assessed at the end of the first week (38 patients) and second week (25 patients) of radiation therapy to investigate trends of motion.ResultsTumors showed irregular occasional rapid motion (eg, swallowing or coughing), periodic intermediate motion (respiration), and slower systematic drifts throughout treatment. For 95% of the patients, displacements due to systematic and random motion were <1.4 mm and <2.1 mm, respectively, 95% of the time. The motion without an ROI mask was significantly (P<.0001, Wilcoxon signed rank test) less than the motion with an ROI mask, indicating that tumors can move independently from the bony anatomy. Tumor motion was significantly (P=.005, Mann-Whitney U test) larger in the hypopharynx and larynx than in the oropharynx. The within-subject coefficient of variation for random motion was 0.33. The average random tumor motion did not increase notably during the first 2 weeks of treatment.ConclusionsThe 3D intrafractional tumor motion of HNSCC is small, with systematic motion <1.4 mm and random motion <2.1 mm 95% of the time.

show abstract

Section: Introductionmentioning

confidence: 99%