Time - Related Salivary Cathepsin B Levels and Periodontal Status in Different Orthodontic Force Magnitudes

Yassir, Yassir A.; Al-Judy, Hikmat J.; Ahmed, Maha Abdul Aziz

doi:10.12816/0015306

Cited by 2 publications

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“…Cathepsin B (CTSB) is a lysosomal cysteine protease which is encoded by CTSB gene and belongs to the class of cysteine cathepsins. It is present and can be found in ample quantities in lysosomes of cells, tissues, serum and saliva (27). It performs physiological functions of protein degradation, lipid and protein metabolism, lysosomal mediated cell death, recycling of growth factor receptors, autophagy and antigen presentation (28).…”

Section: Introductionmentioning

confidence: 99%

Analyzing the Salivary Levels of Cathepsin B in Oral Submucous Fibosis and Oral Squamous Cell Carcinoma for Early Detection

Ahmed,

Shabbir,

Shaikh

et al. 2023

Preprint

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Background: Oral squamous cell carcinoma is one of the most prevalent and common cancers of oral cavity with significant higher rates of mortality and morbidity. Many of the OSCC are known to be preceded by oral potentially malignant disorders such as Oral Submucous Fibrosis. OSF is a chronic and insidious condition with a high malignant transformation potential into OSCC. Salivary biomarker analysis has been considered as a promising approach for early detection of malignant potential of OSF. Cathepsin B is a lysosomal cysteine protease. In many malignancies increased levels of Cathepsin B were observed including OSCC. The present study was designed to analyze and determine the salivary Cathepsin B levels in OSF and OSCC. Method: 150 research participants in total were included in this study which were further divided into 3 groups, 50 in each group. Group 1 comprised 50 OSF patients, Group 2 comprised 50 OSCC patients and group 3 comprised 50 control group. Salivary Cathepsin B levels were analyzed in all 3 groups by using ELISA technique after saliva sample collection. Results: Cathepsin B salivary levels were found to be increased significantly in both OSF and OSCC patients in comparison to control group with significant higher < 0.001 p-value. Highest mean salivary Cathepsin B levels were found in OSF 9.50s ± 7.3, followed by OSCC 4.54 ± 5.9 and control group 0.45s ± 0.9 respectively. Conclusion: Cathepsin B salivary levels were observed to be increased significantly both in patients of OSF and OSCC. Therefore, Cathepsin B can be considered a useful and beneficial salivary biomarker for early detection of OSCC.

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Section: Introductionmentioning

confidence: 99%

Analyzing the Salivary Levels of Cathepsin B in Oral Submucous Fibosis and Oral Squamous Cell Carcinoma for Early Detection

Ahmed,

Shabbir,

Shaikh

et al. 2023

Preprint

View full text Add to dashboard Cite

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Association of salivary Cathepsin B in different histological grades among patients presenting with oral squamous cell carcinoma

et al. 2022

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Background Oral cancer is considered a major public health problem due to its high mortality and morbidity rates. Survival rate of OSCC can be significantly improved by using non-invasive tool such as salivary biomarkers for detection of OSCC which is considered a promising approach. Cathepsin B is a lysosomal cysteine protease, present in abundant quantities in lysosome of cells, tissues and different biological fluids. Increased expression of Cathepsin B was observed in many malignancies including oral cancer. The present study was designed to determine the salivary levels of Cathepsin B in different histological grades of OSCC. Method In this study, total no. of 80 research participants were enrolled which were divided into four groups. Each group comprised 20 participants, group 1 comprised 20 patients of OSCC (well differentiated), group 2 comprised 20 patients of OSCC (moderately differentiated), group 3 comprised 20 patients of OSCC (poorly differentiated) and group 4 comprised 20 healthy controls. Saliva sample was collected from all the four study groups and salivary Cathepsin B levels were analyzed by ELISA sandwich technique in duplicate. Results Salivary levels of Cathepsin B were significantly increased with p value (< 0.001) in patients of OSCC as compared to control group according to both histological grades and tumor size. Highest mean Cathepsin B levels in well differentiated OSCC followed by poorly differentiated OSCC and moderately differentiated OSCC were observed. Conclusion Results of the present study suggests that Cathepsin B has a great value as a salivary biomarker for diagnosis and monitoring of OSCC in different histological grades. This will further lead to increase survival rate and improve the prognosis of OSCC.

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Time - Related Salivary Cathepsin B Levels and Periodontal Status in Different Orthodontic Force Magnitudes

Cited by 2 publications

References 0 publications

Analyzing the Salivary Levels of Cathepsin B in Oral Submucous Fibosis and Oral Squamous Cell Carcinoma for Early Detection

Analyzing the Salivary Levels of Cathepsin B in Oral Submucous Fibosis and Oral Squamous Cell Carcinoma for Early Detection

Association of salivary Cathepsin B in different histological grades among patients presenting with oral squamous cell carcinoma

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