Time-of-Year Variation in Intraocular Pressure

Morettin, Christina; Roberts, Daniel K.; Newman, Tricia L.; Yang, Yongyi; McMahon, Janice; Roberts, Mary Flynn; Teitelbaum, Bruce; Winters, Janis Ecklund

doi:10.1097/ijg.0000000000001930

Cited by 5 publications

(3 citation statements)

References 48 publications

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“… 3 Analyses in this subject area in Chicago, Illinois, United States, recorded an IOP peak in December/January (15.7 ± 3.7/15.7 ± 3.8 mm Hg) and lowest IOP in September (14.5 ± 3.1 mm Hg). 20 A study using results from the UK Biobank of 110,573 participants demonstrated seasonality of IOP with lower values in summer and higher values in winter. 29 In this study IOP peak was recorded in February (14.9 ± 0.48 mm Hg) and lowest IOP in July (14.3 ± 0.43 mm Hg).…”

Section: Discussionmentioning

confidence: 99%

Intraocular Pressure and Its Relation to Climate Parameters—Results From the Gutenberg Health Study

Hartmann

Grabitz

Wild

et al. 2023

Invest. Ophthalmol. Vis. Sci.

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Purpose To investigate the association between intraocular pressure (IOP) and climate parameters. Methods The Gutenberg Health Study (GHS) is a population-based cohort study in Mainz, Germany. Participants underwent two comprehensive ophthalmologic examinations (baseline visit and five-year follow up) including non-contact tonometry, objective refraction, pachymetry, perimetry, and fundus imaging in the time frame of 2007 to 2017. The respective climate parameters were assessed at the University Mainz including temperature, air humidity, and air pressure. Associations of IOP and climatic parameters were computed using component models and cross-correlation plots. Multivariable regression analysis was performed to adjust for age, sex, body mass index, diabetes, central corneal thickness, and systolic blood pressure. To further explore the link between systolic blood pressure, temperature, and IOP, an effect mediation analysis was conducted. Results A total of 14,632 participants (age 55 ± 11 years at baseline, 49.1% female) were included in this analysis. Mean IOP was 14.24 ± 2.8 mm Hg at baseline. There was a similar periodic change in IOP and in temperature, as shown in the component models. IOP was not associated with air humidity. In univariable and multivariable regression analyses we found a significant association between lower IOP during the summer months with higher air temperature (B = −0.011, P < 0.001). This could be partially explained in mediation analysis by lower systolic blood pressure at higher air temperature. Furthermore, IOP was associated with air pressure in univariable (B = 0.005, P = 0.04.) and multivariable models (B = 0.006, P = 0.03). Conclusions There is a periodic annual change of IOP with higher values in winter and lower values in summer supporting the hypothesis of an impact of environmental temperature on IOP, which is partly mediated by lower systolic blood pressure in summer.

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Section: Discussionmentioning

confidence: 99%

Intraocular Pressure and Its Relation to Climate Parameters—Results From the Gutenberg Health Study

Hartmann

Grabitz

Wild

et al. 2023

Invest. Ophthalmol. Vis. Sci.

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“…Intraocular pressure (IOP) is the only modifiable risk factor known to exist. Various internal and external factors, including systemic blood pressure (Klein et al 2005 , Langman et al 2005 ) and ambient temperature (Liao et al 2022 , Morettin et al 2021 , Terauchi et al 2021 ), have an impact on IOP. Older age, non-white race, and family history of glaucoma are other important risk factors (Stein et al 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Impacts of heatwaves and cold spells on glaucoma in rural China: a national cross-sectional study

Wang

Yang

et al. 2023

Environ Sci Pollut Res

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China faces increasing health risks from climate change. The structure and function of the eye and vision were affected by extreme heat and cold. The study aimed to evaluate the impacts of heatwaves and cold spells on glaucoma. A national cross-sectional study of the Rural Epidemiology for Glaucoma (REG-China) was conducted in ten provinces of China, and 36,081 adults aged 40 years or more were included. Glaucoma signs were assessed via a standard examination. A total of 15 heatwave definitions, based on intensity (95th to 99th percentiles of temperature distribution) and duration (≥2 days, 3 days, and 4 days), were used to quantify heatwave effects, and 6 cold spell definitions were defined based on threshold temperature percentile (5th and 10th) and duration (3 days, 5 days, and 9 days). Multivariable-adjusted logistic regression models paired with interaction analysis were performed to investigate the impacts of heatwaves and cold spells on glaucoma, and the dose-response relationships were assessed using a restricted cubic spline (RCS) model. Subgroup analysis was conducted stratified by gender, age, smoking status, occupation, and family history of glaucoma. The overall prevalence of glaucoma was 2.1% (95% CI 1.94–2.25%). Higher heatwaves were significantly correlated with higher OR of glaucoma, with the OR (95% CI) ranging from 1.014 (1.009, 1.018) to 1.090 (1.065, 1.115) by different definitions. Glaucoma was affected by heatwaves more strongly than by cold spells. The effects of both heatwaves and cold spells were higher in males than females and in smokers than nonsmokers. These results of the present study evoked the attention of prospective research to elucidate the relationship between extreme temperatures and eye diseases.

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“…The variance during seasons, temperature changes and the dependence of different weather conditions has been studied in relatively small cohorts in the northern hemisphere [6][7][8][9][10][11][12]. During winter months and therefore lower temperatures, a peak of IOP-values has been found in several studies [13,14].…”

Section: Introductionmentioning

confidence: 99%

Season, weather and intraocular pressure: a monocentric retrospective analysis from 2016 - 2021

Wiedenmann

Böhringer

Reinhard

et al. 2023

Preprint

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Background We herein investigate the relationship between intraocular pressure (IOP) and environmental factors such as daily mean temperature, daily sunshine duration and daily mean atmospheric pressure.Methods We reviewed all IOP measurements of out-patients by non-contact tonometry that had been recorded between 2016 and 2021 (N = 199,804) in the Eye Center, University Hospital Freiburg, Germany. IOP values below 5 and above 30 mm Hg were excluded. No other exclusion criteria applied. Analysis of variance was performed to assess seasonal variations in IOP. We fitted a linear regression model to analyze the respective influences of age at time of measurement, daily mean temperature, daily sunshine duration and daily mean atmospheric pressure on IOP. We also performed cross-correlations to check for periodicity and time lag between IOP and the aforementioned environmental factors.Results IOP was highest in January (15.0 ± 3.8 mm Hg) and lowest in July (14.6 ± 3.6 mm Hg). Cross-correlation and Fourier analysis support annual periodicity and a seasonal pattern of IOP. Multiple linear regression revealed a significant negative correlation of daily mean temperature with IOP. Sunshine duration at the day of measurement did not correlate with IOP, but the total sunshine duration of the preceding ten days before measurement revealed a significant negative correlation. Atmospheric pressure missed statistical significance at multifactorial level.Conclusions We observed an annual periodic IOP variation with an amplitude of ≈ 0.4 mm Hg. The variation is most likely attributable to a direct effect of environmental temperature and secondly to biological factors triggered by sunshine exposure over the preceding ten days.

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Time-of-Year Variation in Intraocular Pressure

Cited by 5 publications

References 48 publications

Intraocular Pressure and Its Relation to Climate Parameters—Results From the Gutenberg Health Study

Intraocular Pressure and Its Relation to Climate Parameters—Results From the Gutenberg Health Study

Impacts of heatwaves and cold spells on glaucoma in rural China: a national cross-sectional study

Season, weather and intraocular pressure: a monocentric retrospective analysis from 2016 - 2021

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