Time of neuron origin in the amygdaloid complex of the mouse

McConnell, Joann; Angevine, Jay B.

doi:10.1016/0006-8993(83)90372-4

Cited by 42 publications

(33 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, it is difficult to determine whether a portion of the lateral pallium is also affected in these mutants because of a lack of specific markers for this pallial region. These amygdalar nuclei are largely generated between E11 and E14 in the mouse (McConnell and Angevine, 1983), which correlates well with the timing of the observed patterning defects in Tlx mutants. Moreover, our fate-mapping studies, using the subpallial Dlx5/6 expression domain, demonstrate a largely pallial origin for the basolateral and lateral amygdala because only a few cells are labeled in these nuclei.…”

Section: Tlx Is Required For Patterning Of the Lateral Telencephalonsupporting

confidence: 72%

TlxandPax6co-operate genetically to establish the pallio-subpallial boundary in the embryonic mouse telencephalon

et al. 2003

View full text Add to dashboard Cite

We have examined the role of Tlx, an orphan nuclear receptor, in dorsal-ventral patterning of the mouse telencephalon. Tlx is expressed broadly in the ventricular zone, with the exception of the dorsomedial and ventromedial regions. The expression spans the palliosubpallial boundary, which separates the dorsal (i.e. pallium) and ventral (i.e. subpallium) telencephalon. Despite being expressed on both sides of the palliosubpallial boundary, Tlx homozygous mutants display alterations in the development of this boundary. These alterations include a dorsal shift in the expression limits of certain genes that abut at the pallio-subpallial boundary as well as the abnormal formation of the radial glial palisade that normally marks this boundary. The Tlx mutant phenotype is similar to, but less severe than, that seen in

show abstract

Section: Tlx Is Required For Patterning Of the Lateral Telencephalonsupporting

confidence: 72%

TlxandPax6co-operate genetically to establish the pallio-subpallial boundary in the embryonic mouse telencephalon

et al. 2003

View full text Add to dashboard Cite

show abstract

“…Interestingly, although proper CSB border positioning is reestablished by midneurogenesis in Gsh2 Ϫ/Ϫ mutants (Corbin et al, 2000;Toresson et al, 2000;Toresson and Campbell, 2001;Yun et al, 2001), the loss of Dlx2 ϩ cells along the LCS, unlike the olfactory bulb interneuron defect in these mice, does not partially recover. This may reflect that fact that cells of the basal telencephalic limbic system appear to be specified during a fixed window of development (McConnell and Angevine, 1983;Bayer and Altman, 1991; present study), whereas olfactory bulb neurogenesis continues through adulthood (for review, see Alvarez-Buylla and GarciaVerdugo, 2002).…”

Section: Gsh2 Is Required For the Generation Of The Lateral Cortical mentioning

confidence: 71%

Cell Migration along the Lateral Cortical Stream to the Developing Basal Telencephalic Limbic System

Carney¹,

Alfonso²,

Cohen³

et al. 2006

J. Neurosci.

113

View full text Add to dashboard Cite

During embryogenesis, the lateral cortical stream (LCS) emerges from the corticostriatal border (CSB), the boundary between the developing cerebral cortex and striatum. The LCS is comprised of a mix of pallial-and subpallial-derived neural progenitor cells that migrate to the developing structures of the basal telencephalon, most notably the piriform cortex and amygdala. Using a combination of in vitro and in vivo approaches, we analyzed the timing, composition, migratory modes, origin, and requirement of the homeodomaincontaining transcription factor Gsh2 (genomic screened homeobox 2) in the development of this prominent migratory stream. We reveal that Pax6 (paired box gene 6)-positive pallial-derived and Dlx2 (distal-less homeobox 2)-positive subpallial-derived subpopulations of LCS cells are generated in distinct temporal windows during embryogenesis. Furthermore, our data indicate the CSB border not only is comprised of separate populations of pallial-and subpallial-derived progenitors that contribute to the LCS but also a subpopulation of cells coexpressing Pax6 and Dlx2. Moreover, despite migrating along a route outlined by a cascade of radial glia, the Dlx2-positive population appears to migrate primarily in an apparent chain-like manner, with LCS migratory cells being generated locally at the CSB with little contribution from other subpallial structures such as the medial, lateral, or caudal ganglionic eminences. We further demonstrate that the generation of the LCS is dependent on the homeodomain-containing gene Gsh2, revealing a novel requirement for Gsh2 in telencephalic development.

show abstract

“…In the beginning, we applied DiI to the caudal ganglionic eminence of E11.5, since the initial neurogenesis of amygdalar neurons was reported at this stage (McConnell and Angevine 1983). Only small numbers of growth cones were observed to extend medially from the injection site ( Fig.…”

Section: Development Of Amygdalohypothalamic Projections As Revealed mentioning

confidence: 98%

“…The mammalian ST is considered to be involved in transfer of the emotion-related information integrated in the amygdaloid complex to the hypothalamus, interacting with each part of the BNST along the trajectory (Alheid et al 1998;Shammah-Lagnado et al 2000). Thus, ST is involved in the output of the evaluation of external sensory stimuli to the autonomic and endocrine center, the hypothalamus, and in the control of adaptive responses as revealed by anatomical, physiological and behavioral findings (Heimer et al 1991) Though the functional aspects of the amygdaloid complex have been extensively investigated, only a few studies have focused on the developmental mechanisms of the amygdala and related structures, namely birth date studies of the amygdaloid neurons (Bayer 1980;McConnell and Angevine 1983;Bayer 1987), the immunohistochemical examination of developing amygdala and BNST in the rodent and chick (Song and Harlan 1994;Al-Shamma and De Vries 1996;Han and De Vries 1999;Jurkevich et al 1999), and morphological analysis of the human fetal amygdala (Johnston 1923;Ulfig et al 1998;Ulfig 2002). Few studies carried out to date have examined the axonal development of embryonic amygdalofugal pathways.…”

Section: Introductionmentioning

confidence: 99%

Development of the amygdalohypothalamic projection in the mouse embryonic forebrain

et al. 2004

View full text Add to dashboard Cite

The amygdalohypothalamic projection, a major component of the stria terminalis, is involved in the conduction of emotional and olfactory information integrated in the amygdala to the hypothalamus to elicit emotional reactions. Despite the extensive studies on functional aspects of the amygdaloid complex, developmental mechanisms of the amygdala and related structures are still poorly understood. To investigate the development of the amygdalohypothalamic projection in the mouse embryonic brain, carbocyanine dye was applied to the amygdala to label the growing axons anterogradely and to the hypothalamus to label the amygdaloid neurons retrogradely. The initial outgrowth of the stria terminalis was found to be as early as E11.5. The pathway crossed in a saddle over the internal capsule, another prominent connection in the developing forebrain of the mammalian embryo. Bipolar immature neurons were distributed along the stria terminalis at the telencephalo-diencephalic boundary, and the internal capsule was also surrounded by these cells. These cells expressed immunoreactivities to calretinin and the lot-1 antigen which has been shown to be involved in guidance of the developing lateral olfactory tract. Ultrastructural analysis revealed an adherens-like junction between the stria terminalis and the apposed cells, implying contact-mediated guidance. These results suggest that, in the development of the stria terminalis, the axonal outgrowth is guided by a mechanism similar to that of the developing lateral olfactory tract, a major amygdalopetal connection.

show abstract

Time of neuron origin in the amygdaloid complex of the mouse

Cited by 42 publications

References 14 publications

TlxandPax6co-operate genetically to establish the pallio-subpallial boundary in the embryonic mouse telencephalon

TlxandPax6co-operate genetically to establish the pallio-subpallial boundary in the embryonic mouse telencephalon

Cell Migration along the Lateral Cortical Stream to the Developing Basal Telencephalic Limbic System

Development of the amygdalohypothalamic projection in the mouse embryonic forebrain

Contact Info

Product

Resources

About