Time-of-day Effects of Ethanol Consumption on EEG Topography and Cognitive Event-related Potential in Adult Males.

Liu, Yang; Higuchi, Shigekazu; Motohashi, Yutaka

doi:10.2114/jpa.19.249

Cited by 12 publications

(12 citation statements)

References 17 publications

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“…For example, recent electrophysiological recordings observed time-of-day effects of ethanol consumption on EEG topography. In a study investigating the effects of ethanol on the P300 event-related potential, Liu et al (2000) could show a decrease of the ␣2-amplitude in the morning but not in the evening. Conversely, the P300 amplitude was lowered in the evening but not in the morning.…”

Section: Genetic Variations Of Human Clock Genes Are Associated With mentioning

confidence: 96%

“…In humans, chronic alcoholism is associated with dramatic disruptions in sleep and other circadian biological rhythms, including body temperature, blood pressure, metabolism, hormone secretion, and EEG topography (Brower, 2001;Devaney et al, 2003;Fonzi et al, 1994;Imatoh et al, 1986;Kawano et al, 2002;Kodama et al, 1988;Liu et al 2000, Mukai et al, 1998Numminen et al, 2000;Sano et al, 1993;Schmitz et al, 1996). These wide-spread chronobiological disruptions are similar to those associated with mood disorders (Rosenwasser and Wirz-Justice, 1997), and, indeed, mood dysregulation is a hallmark of alcohol withdrawal (Driessen et al, 2001).…”

Section: Circadian Rhythms and Cellular Clocksmentioning

confidence: 99%

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Alcohol Consumption and the Body???s Biological Clock

Spanagel¹,

Rosenwasser²,

Schumann³

et al. 2005

Alcoholism: Clinical & Experimental Research

146

122

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This review summarizes new findings on the bidirectional interactions between alcohol and the clock genes, underlying the generation of circadian rhythmicity. At the behavioral level, both adult and perinatal ethanol treatments after the free-running period and light response of the circadian clock in rodents; genetic ethanol preference in alcohol-preferring rat lines is also associated with alterations in circadian pacemaker function. At the neuronal level, it has been shown that ethanol consumption alters the circadian expression patterns of period (per) genes in various brain regions, including the suprachiasmatic nucleus. Notably, circadian functions of beta-endorphin-containing neurons that participate in the control of alcohol reinforcement become disturbed after chronic alcohol intake. In turn, per2 gene activity regulates alcohol intake through its effects on the glutamatergic system through glutamate reuptake mechanisms and thereby may affect a variety of physiological processes that are governed by our internal clock. In summary, a new pathologic chain has been identified that contributes to the negative health consequences of chronic alcohol intake. Thus, chronic alcohol intake alters the expression of per genes, and as a consequence, a variety of neurochemical and neuroendocrine functions become disturbed. Further steps in this pathologic chain are alterations in physiological and immune functions that are under circadian control, and, as a final consequence, addictive behavior might be triggered or sustained by this cascade.

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Section: Genetic Variations Of Human Clock Genes Are Associated With mentioning

confidence: 96%

Section: Circadian Rhythms and Cellular Clocksmentioning

confidence: 99%

Alcohol Consumption and the Body???s Biological Clock

Spanagel¹,

Rosenwasser²,

Schumann³

et al. 2005

Alcoholism: Clinical & Experimental Research

146

122

View full text Add to dashboard Cite

show abstract

“…Unfortunately, ethanol, unlike most other psychoactive substances, is not linked to any particular receptors in specific brain areas, thus making it more difficult to determine which brain mechanisms are most likely to be vulnerable to alcohol intoxication. Indeed, studies in humans and rodents have mainly shown a general reduction in cortical activity due to ethanol (Davies and Alkana 2001;Wang et al 1999;Krull et al 1994;Liu et al 2000). However, the underlying physiological structures that are relevant to our study can be linked to different modules of the theoretical framework introduced above.…”

Section: Introductionmentioning

confidence: 98%

Specific visuomotor deficits due to alcohol intoxication: Evidence from the pro- and antisaccade paradigms

et al. 2007

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The saccade latency data strongly suggest that alcohol intoxication impairs temporal aspects of saccade generation, irrespective of the level of processing triggering the saccade. The absence of effects on anti-saccade errors calls for further research into the notion of alcohol-induced impairment of the ability to inhibit prepotent responses. Furthermore, the specific impairment of saccade amplitude in the anti-saccade task under alcohol suggests that higher level processes involved in the spatial remapping of target location in the absence of a visually specified saccade goal are specifically affected by alcohol intoxication.

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“…Alcohol: In humans, chronic alcohol intake is associated with sleep disturbance and alterations in various daily physiological rhythms, including blood pressure, body temperature, metabolism, hormone secretion, and EEG topography [256][257][258][259][260][261]. Similar chronobiological disruptions were observed in patients with mood disorders [262].…”

Section: Drugs That Bind To Ionotropic Receptors and Ion Channelsmentioning

confidence: 98%

The Circadian Clock

Albrecht¹

2010

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except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights.Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com) v PrefaceWith the invitation to edit this volume, I wanted to take the opportunity to assemble reviews on different aspects of circadian clocks and rhythms. Although most contributions in this volume focus on mammalian circadian clocks, the historical introduction and comparative clocks section illustrate the importance of various other organisms in deciphering the mechanisms and principles of circadian biology.Circadian rhythms have been studied for centuries, but only recently, a molecular understanding of this process has emerged. This has taken research on circadian clocks from mystic phenomenology to a mechanistic level; chains of molecular events can describe phenomena with remarkable accuracy. Nevertheless, current models of the functioning of circadian clocks are still rudimentary. This is not due to the faultiness of discovered mechanisms, but due to the lack of undiscovered processes involved in contributing to circadian rhythmicity. We know for example, that the general circadian mechanism is not regulated equally in all tissues of mammals. Hence, a lot still needs to be discovered to get a full understanding of circadian rhythms at the systems level. In this respect, technology has advanced at high speed in the last years and provided us with data illustrating the sheer complexity of regulation of physiological processes in organisms. To handle this information, computer aided integration of the results is of utmost importance in order to discover novel concepts that ultimately need to be tested experimentally. In this development of new concepts lies the chance to understand living organisms better and to develop strategies to apply these new concepts for the benefit of society. A decade ago, the influence of changing day-night cycles (e.g. jet-lag and shift work) on health was intuitively possible but not taken very seriously due to lack of convincing scientific evidence. This has changed in the last years due to discoveries illustrating the involvement of clock components in the development of cancer, obesity and mood disorders.The main task of the circadian clock is to optimize an organism's performance and tune it with temporal changes in the environment. In that sense, the clock links the genetic setting of the organism with its environment. A better understanding of the circadian clock, therefore, will open avenues for treatment of diseases via environmental stimuli such as light. The importance...

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Time-of-day Effects of Ethanol Consumption on EEG Topography and Cognitive Event-related Potential in Adult Males.

Cited by 12 publications

References 17 publications

Alcohol Consumption and the Body???s Biological Clock

Alcohol Consumption and the Body???s Biological Clock

Specific visuomotor deficits due to alcohol intoxication: Evidence from the pro- and antisaccade paradigms

The Circadian Clock

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