“… 24 , 25 For the other models, a severe phenotype was observed with spontaneous epileptic seizures ranging from partial seizures to generalized tonic‐clonic, accompanied by cognitive deficits consisting of learning and memory deficits, hyperactivity, and a decrease in the M current. 37 , 38 , 39 , 40 To explore the consequences of M‐current suppression for the epileptic phenotype, a homozygous model was created bearing the variant p.(S559A), which attenuates the neurotransmitter‐induced M‐current suppression. 41 In addition, studies of the p.(G279S) variant allowed highlighting of the role of Kcnq2 ‐related neuronal hyperexcitability in the forebrain for the perception of visceral pain, 42 on the fear memory trace, 43 and to study the relationship between the peptide hormone ghrelin and Kcnq2 in the context of dopaminergic neurotransmission.…”