Time labelling of independently acquired lateralized engrams in rats

Goldowitz, Daniel; Burešová, O.; Bureš, Jan

doi:10.1016/0031-9384(72)90037-6

Cited by 4 publications

(2 citation statements)

References 13 publications

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“…On Day 1, left/right discrimination memory was lateralized using the protocol of Goldowitz et al [18]. Naïve rats were given intensive left/right discrimination training in the Y-maze under unilateral cortical spreading depression (CSD) [19].…”

Section: Resultsmentioning

confidence: 99%

Stress-Induced Out-of-Context Activation of Memory

et al. 2010

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Section: Resultsmentioning

confidence: 99%

Stress-Induced Out-of-Context Activation of Memory

et al. 2010

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“…The results of experiment 3 confirm the assumption that the memory traces formed during lateralized navigation training are lateralized and do not spontaneously transfer to the other hemisphere, so that at the time of synthesis both hemispheres contain different pieces of information pertinent to the same navigation task. In this respect, place navigation resembles visual discrimination learning or active avoidance learning which can be lateralized during unilateral functional decortication by cortical spreading depression (Buresova and Bures, 1971, 1973Buresova et al, 1971;Goldowitz et al, 1972) Inactivation of the dorsal hippocampus elicits effective blockade of target-directed navigation although it leaves the ventral hippocampus intact. This is not surprising if we take into account that the lidocaine injection blocks impulse conduction in the septohippocampal pathway mediating the main cholinergic input to the hippocampus.…”

Section: Ablation Proceduresmentioning

confidence: 99%

Interhippocampal synthesis of lateralized place navigation engrams

et al. 1995

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Rats were trained in a water maze in a dark room with the extramaze cues restricted to only dimly back-lit shapes. We used lidocaine to reversibly lesion the dorsal hippocampus and this controlled-cue room in order to examine interhippocampal synthesis of lateralized place engrams. Experiment 1 showed that lidocaine injected into both hippocampi effectively abolished place navigation for up to 25 min but not at 45 min. In experiment 2, each day under lidocaine blockade of one hippocampus, pretrained rats were trained in the water maze to locate the target according to two cues (e.g., AB). Two hours later, the contralateral hippocampus was inactivated and the rats were trained to the same location with two other cues (CD). On day 5, intact brain retrieval was tested in one of three conditions: ACQ (e.g., AB), one of the pairs of cues used in acquisition training; SYNTH (e.g., AC), one cue from each of the pairs used in acquisition; CONT (e.g., AE), one cue that was used in acquisition training and a novel cue. The results show that the hippocampi learned the two tasks independently and similarly [latency (L) at the asymptote = 7 s]. Retrieval performance was at the asymptote for ACQ (AB) and SYNTH (AC) (L = 6 and 7, respectively) but was disrupted for CONT (L = 12). In experiment 3 as in experiment 2, the rats were trained, under unilateral blockade, to a new place for 4 days. On day 5, retrieval with the trained hippocampus blocked was worse (L = 11) than with the untrained side blocked (L = 5).(ABSTRACT TRUNCATED AT 250 WORDS)

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Learning and Memory

Bureš

Burešová

1976

Techniques and Basic Experiments for the Study of Brain and Behavior

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Time labelling of independently acquired lateralized engrams in rats

Cited by 4 publications

References 13 publications

Stress-Induced Out-of-Context Activation of Memory

Stress-Induced Out-of-Context Activation of Memory

Interhippocampal synthesis of lateralized place navigation engrams

Learning and Memory

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