Time-kill Curve Studies of Ampucare Against Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae and Proteus vulgaris

Shrivastava, Sanjay Mohan; Kumar, Sanjeev; Chaudhary, Manu

doi:10.3923/rjmp.2009.116.122

Cited by 7 publications

(4 citation statements)

References 15 publications

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“…Many of bacterial strains are resistant to the standard antibiotic (Co-trimozaxol) comparatively to the polyphenol-rich fractions. One could say that, the metabolites have been shown to be responsible for therapeutic activity of plants [ 27 ]. According to a recent study, aqueous acetone extract of Sida alba L. contains saponosides, coumarins, steroids, polyphenol compounds and alkaloids [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial activity of polyphenol-rich fractions from Sida alba L. (Malvaceae) against co-trimoxazol-resistant bacteria strains

Konaté

Hilou

Mavoungou

et al. 2012

Ann Clin Microbiol Antimicrob

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BackgroundThe increased resistance of microorganisms to the currently used antimicrobials has lead to the evaluation of other agents that might have antimicrobial activity. Medicinal plants are sources of phytochemicals which are able to initiate different biological activities including antimicrobialsMaterials and methodsIn vitro antibacterial (MIC, MBC and time-kill studies) of polyphenol-rich fractions from Sida alba L. (Malvaceae) was assessed using ten bacteria strains (Gram-negative and Gram-positive).ResultsAll test bacteria were susceptible to the polyphenol-rich fractions. Time-kill results showed that after 5 h exposition there was no viable microorganism in the initial inoculum and the effect of polyphenol-rich fractions was faster on Enterococcus faecalis (Gram-positive bacterium) comparatively to the other bacteria strains.ConclusionThe data analysis indicates that the tested of polyphenol-rich fractions has significant effects when compared with the standard antibiotic. These results therefore justify the traditional use of sida alba L., alone or in combination with other herbs to treat bacterial infections.

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Section: Discussionmentioning

confidence: 99%

Antimicrobial activity of polyphenol-rich fractions from Sida alba L. (Malvaceae) against co-trimoxazol-resistant bacteria strains

Konaté

Hilou

Mavoungou

et al. 2012

Ann Clin Microbiol Antimicrob

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“…Many bacterial strains are resistant to the standard antibiotic (amoxicillin) compared to the polyphenol-rich fractions. It could be said that metabolites have been found to be responsible for the therapeutic activity of plants [33]. This may be due to the presence of coumarins, polyphenolic compounds (tannins, coumarins and flavonoids) which we had then identified in Solanum extracts on one hand and on the other hand by the alcohols, saponosides, steroids, etc.…”

Section: Discussionmentioning

confidence: 91%

Study of the antibacterial capacity of extracts of Solanum incanum L., (Solanaceae) traditionally used for the management of avian cholera in rural areas of Burkina Faso

Séré¹,

Konaté²,

Santara³

et al. 2022

World J. Adv. Res. Rev.

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Nowadays, thanks to the rise of microbial resistance, the lack of health care personnel and especially the high cost of synthetic molecules, phytotherapy could be a panacea in many developing countries. For this reason, the present work which aims to evaluate the phenolic compounds and to study the antibacterial capacity of extracts of roots, stems, leaves and fruits of Solanum incanum L., (Solanaceae) traditionally used for the treatment of pasteurellosis or avian cholera in Burkina Faso, was undertaken. For this purpose, we collected plant material in the commune of Dedougou. After extraction with acetone and water, colorimetric tests were carried out on the different extracts and revealed mostly the presence of tannins and coumarins. The Hydroacetone macerated extract was found to be very interesting for biological activities compared to the macerated extracts and the aqueous decoctions. Inhibition of bacterial growth on different bacterial strains was also shown for all the extracts, especially with Hydroacetone extract. These results could be mainly explained by the inhibitory effect of phenolic compounds. The Hydroacetone extract was also found to be especially very relevant for the prevention and treatment of microbial diseases from poultry.

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“…Some pictures are also showing beneficial effect of local application of ampucare in patients with bedsore. 11 Thus, antimicrobial activity of natural products 12 helps in reducing infection in the wound area and the surrounding skin and ultimately promotes early healing of bed sore. The wound is rich in oxidants such as hydrogen peroxide.…”

Section: Resultsmentioning

confidence: 99%

An open labeled study to evaluate efficacy and safety of ampucare in patients with bedsore

Singh

Sangwan

Singh

et al. 2013

Int J Basic Clin Pharmacol

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Background: To evaluate efficacy and safety of ampucare, a polyherbal product, in patients with bedsore. Methods: One hundred patients, either sex, more than 18 years of age, with bedsore were divided in to two groups of 50 each. Group-I- Served as control- povidone iodine solution was applied locally on the bedsore, once daily. Group- II- Treatment group- ampucare lotion was applied locally, once daily. Primary end point was time to wound healing and secondary end point included reduction in wound surface area at day-7 and at treatment completion. Percent patients cured, improved, or treatment failure were noted. Depth of wound, % healing and adverse effects were recorded. Results: Application of ampucare in patients with bedsore resulted in rapid healing as compared to control group. Reduction in wound surface area was significant (p<0.01) in group-II. Maximum gain in thickness of granular tissue was observed in this group. In treatment group 68% patients showed excellent response as compared to 60 % in control group. Ampucare was well tolerated. Conclusions: Ampucare treatment markedly accelerates wound healing in patients with bedsore. [Int J Basic Clin Pharmacol 2013; 2(4.000): 371-374

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Time-kill Curve Studies of Ampucare Against Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae and Proteus vulgaris

Cited by 7 publications

References 15 publications

Antimicrobial activity of polyphenol-rich fractions from Sida alba L. (Malvaceae) against co-trimoxazol-resistant bacteria strains

Antimicrobial activity of polyphenol-rich fractions from Sida alba L. (Malvaceae) against co-trimoxazol-resistant bacteria strains

Study of the antibacterial capacity of extracts of Solanum incanum L., (Solanaceae) traditionally used for the management of avian cholera in rural areas of Burkina Faso

An open labeled study to evaluate efficacy and safety of ampucare in patients with bedsore

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