Time in Therapeutic Range of Oral Vitamin K Antagonists in Hospitalized Elderly Patients

Lafarge, L.; Khayi, F; Bel-Kamel, Anis; Charhon, Nicolas; Sarfati, L.; Falquet, B.; Ducher, Michel; Bourguignon, Laurent

doi:10.1007/s40266-018-0551-5

Cited by 2 publications

(2 citation statements)

References 39 publications

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“…Additionally, we found that vitamin K is positively and significantly associated with TSH, TC, LDL, and sdLDL levels. Oral vitamin K antagonists (VKAs) have been shown to alter TSH levels in elderly hospitalized patients, 29 a variable directly linked to the development of depression. 30 Moreover, vitamin K might positively impact serum lipids and lipid metabolism.…”

Section: Discussionmentioning

confidence: 99%

Associations Between Vitamin K and Suicide Attempts in Patients with Depression: A Case-Control Study

Wang,

He,

et al. 2024

JIR

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Background: Hypovitaminosis K has been linked to depression and suicide, but epidemiological research is scarce. This study aimed to explore the association among vitamin K with depression and suicidal attempts. Methods: This was a retrospective cross-sectional study involving 146 cases with a history of suicidal attempts and 149 subjects without a lifetime history of suicidal attempts. The levels of thyroid hormones, lipid profile, inflammatory cytokines, and vitamins were measured. Results: Subjects who had suicidal attempts presented with a significant decrease in FT4, TC, vitamin D, and vitamin K but increased CRP levels. In these variables, vitamin K has a better diagnostic value for suicidal attempts in depressed patients, with a sensitivity of 0.842 and a specificity of 0.715. Correlation analysis suggested that vitamin K was significantly and positively related to FT4, TC, LDL, and sdLDL. Multivariate analysis showed that serum vitamin K level predicts suicidal attempts in depressive patients (OR = 0.614, P = 0.004, 95% CI 0.153-0.904). Moreover, a negative correlation between vitamin K and suicidal attempts was also noted for partial FT4, CRP, and vitamin D strata analysis. Conclusion:Our study suggests that low vitamin K levels were correlated with suicidal attempts in patients with depression, indicating that vitamin K deficiency might be a biological risk factor for depression.

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Section: Discussionmentioning

confidence: 99%

Associations Between Vitamin K and Suicide Attempts in Patients with Depression: A Case-Control Study

Wang,

He,

et al. 2024

JIR

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“…The safety profile is as good as in younger patients, with the only increased risk being for nonfatal gastrointestinal bleeding [23]. It is important to note that, in geriatric populations, the time in the therapeutic range (TTR) of VKAs tends to be lower than in the general population: this means that most patients are exposed to an increased risk of thromboembolic and hemorrhagic events [24]. Additionally, VKA prescription can be motivated by the concern for the renal dysfunction typically present in elderly patients: in fact, even in our population, CKD was one of the most frequent comorbidities, and the hepatic metabolism of VKAs could lead the physicians to prefer drugs potentially less deleterious for these patients.…”

Section: Discussionmentioning

confidence: 99%

Current Use of Oral Anticoagulation Therapy in Elderly Patients with Atrial Fibrillation: Results from an Italian Multicenter Prospective Study—The ISNEP Study

Stefano

Benassi

Cappelletti

et al. 2022

JPM

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Background: Atrial fibrillation (AF) is the most common heart arrhythmia, and its prevalence increases with age. Oral Anticoagulant Therapy (OAT) with non-vitamin K antagonist oral anticoagulants (NOACs) or vitamin K antagonists (VKAs) is essential to avoid thromboembolic events in AF. However, this treatment is associated with a high risk of bleeding and low adherence in elderly patients. Aim: The aim was to evaluate the real-world use of OAT in a population of patients aged ≥80 years in twenty-three Italian centers and to investigate the tolerance of and patient satisfaction with this therapy. Methods: The ISNEP Study is a multicenter cross-sectional study enrolling patients with AF and aged ≥80 years and treated with either NOACs or VKAs. A written questionnaire was administered to each patient to evaluate the adherence to and patient satisfaction with this therapy. Results: The study included 641 patients with a mean age of 85 (82–87) years. The use of NOACs was reported in 93.0% of cases, with the remaining 7.0% treated with VKAs. A history of stroke events was reported in five (11.1%) and one (0.2%) patients in the VKA and NOAC groups, respectively. The rate of referred ecchymosis/epistaxis was significantly higher in the VKA group compared to the NOAC group (p < 0.001). Patients receiving NOACs reported a substantial improvement in their quality of life compared to the VKA group. Conclusions: A small, but not negligible, proportion of elderly AF patients is still treated with VKAs. Patients treated with NOAC have a higher level of satisfaction with the therapy and complete adherence.

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Time in Therapeutic Range of Oral Vitamin K Antagonists in Hospitalized Elderly Patients

Cited by 2 publications

References 39 publications

Associations Between Vitamin K and Suicide Attempts in Patients with Depression: A Case-Control Study

Associations Between Vitamin K and Suicide Attempts in Patients with Depression: A Case-Control Study

Current Use of Oral Anticoagulation Therapy in Elderly Patients with Atrial Fibrillation: Results from an Italian Multicenter Prospective Study—The ISNEP Study

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