Time-gated x-ray tomography

Grätz, Matthias; Kiernan, L; Wahlström, Claes‐Göran; Svanberg, Sune; Herrlin, Kristian

doi:10.1063/1.122623

Cited by 12 publications

(8 citation statements)

References 11 publications

(11 reference statements)

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“…This enables gated viewing, which has the potential of decreasing the patient dose without causing deteriorating of the contrast in the diagnostic images. 40 Thus, the combination of the readily achievable realistic exposure times and the gated viewing technique clearly motivates more investigations in this area.…”

Section: Discussionmentioning

confidence: 99%

High-repetition-rate, hard x-ray radiation from a laser-produced plasma: Photon yield and application considerations

Sjögren

Harbst

Wahlström

et al. 2003

Review of Scientific Instruments

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High-repetition-rate, hard x-ray radiation from a laser-produced plasma: Photon yield and application considerations Sjögren, Anders; Harbst, Michael; Wahlström, Claes-Göran; Svanberg, Sune; Olsson, C Link to publication Citation for published version (APA): Sjögren, A., Harbst, M., Wahlström, C-G., Svanberg, S., & Olsson, C. (2003). High-repetition-rate, hard x-ray radiation from a laser-produced plasma: Photon yield and application considerations. Review of Scientific Instruments, 74(4), 2300-2311. DOI: 10.1063/1.1544054General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal High-repetition-rate, hard x-ray radiation from a laser-produced plasma: Photon yield and application considerations We present an experimental study of hard x rays produced in laser-produced plasmas. The laser used is a 1 kHz system, delivering 0.7 mJ for 25 fs onto a solid target. The x-ray spectrum was measured with calibrated germanium detectors, allowing a very good estimate of the absolute number of photons emitted from the plasma over a wide energy range; from 7 keV to 0.5 MeV. Assuming a bi-Maxwellian electron distribution with temperatures of 4.5 and 63 keV, theoretical calculations support the experimental findings. The imaging characteristics of the x-ray source were investigated experimentally employing image plates and theoretically based on the electron distribution.

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Section: Discussionmentioning

confidence: 99%

High-repetition-rate, hard x-ray radiation from a laser-produced plasma: Photon yield and application considerations

Sjögren

Harbst

Wahlström

et al. 2003

Review of Scientific Instruments

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“…By restricting the imaging to the ballistic photons only, contrast is enhanced. Recently, the gated-viewing concept has been combined with tomographic back-projection to yield scatter-reduced twodimensional images of tissue phantoms (See figure 9) [39,40].…”

Section: X-ray Generation and Applicationsmentioning

confidence: 99%

Some applications of ultrashort laser pulses in biology and medicine

Svanberg

2001

Meas. Sci. Technol.

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Ultrashort laser pulses are finding increasing applications in biology and medicine. Such pulses can be used directly or after non-linear modification. Direct utilization includes propagation studies in scattering media with applications in optical mammography, dosimetry for photodynamic therapy and species concentration assessment. Intense continua of electromagnetic radiation of very brief duration are formed in the interaction of focused ultrashort and intense laser pulses with matter. Two different kinds of experiment using such radiation are described, employing visible radiation and x-rays, respectively. Focusing into water leads to the generation of a light continuum through self-phase modulation. The propagation of the light through tissue was studied, addressing questions related to specific tissue chromophore absorption. When terawatt laser pulses are focused onto a solid target with high nuclear charge Z, intense x-ray radiation of few ps duration and with energies exceeding hundreds of keV is emitted. Biomedical applications of this radiation are described, including differential absorption and gated-viewing imaging.

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“…The potential of medical X-ray gated viewing was first pointed out in [43]. We have performed detailed studies of gated X-ray detection using a 10Hz high-energy laser system in combination with an X-ray streak camera [44], and also demonstrated gated tomographic X-ray imaging [ 45].…”

Section: Laser-produced X-raysmentioning

confidence: 99%

Some Medical and Biological Applications of Ultrafast Lasers

Svanberg

2004

Springer Series in OPTICAL SCIENCES

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Ultrashort lasers are finding many applications in medicine and biology. Pulses from such systems can be used directly or after non-linear modification. Direct utilisation includes time-resolved fluorescence spectroscopy and imaging. Such studies can be performed for tissue diagnosis in the field of malignant diseases as well as in the cardiovascular sector. Two-photon induced fluorescence provides a basis for high-quality optical microscopy, and optical coherence tomography with ultra-short and thus broadband pulses allow a radar-like depth-ranging into tissue. Photon propagation in scattering media also has important applications in optical mammography, dosimetry for photodynamic therapy and species concentration assessment. Intense continua of electromagnetic radiation of very brief duration are formed in the interaction of focused ultra-short and intense laser pulses with matter. Focusing into water, or better, a photonic band-gap fibre, leads to the generation of a light continuum through self-phase modulation. The propagation of white light through tissue was studied addressing questions related to tissue chromophore concentration measurements employing their absorptive imprint in the light. Even free gas enclosures in solids and liquids give rise to an absorptive signature, which, however, is typically 104 times narrower than spectral structures in the matrix material. Such sharp features are best detected by wavelength modulation of a single-mode laser, and many new applications of gas-in-scattering-media absorption spectroscopy (GASMAS) are developing. When terawatt laser pulses are focused onto a solid target with high nuclear charge Z, intense X-ray radiation of few ps duration and with energies exceeding hundreds of ke V is emitted. Biomedical applications of this radiation are described, including differential absorption and gatedviewing imaging.

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Time-gated x-ray tomography

Cited by 12 publications

References 11 publications

High-repetition-rate, hard x-ray radiation from a laser-produced plasma: Photon yield and application considerations

High-repetition-rate, hard x-ray radiation from a laser-produced plasma: Photon yield and application considerations

Some applications of ultrashort laser pulses in biology and medicine

Some Medical and Biological Applications of Ultrafast Lasers

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