“…The presence of signal processing artifact has been discussed by many authors (see, for example) DURAND and PIBAROT (1995), CHEN and DURAND (1997a), WOOD and BARRY (1995), XU and DURAND (2000;, WOOD and BUOA, (1992), BARRY and WOOD (1991) and DURAND and Guo (1992)) and must motivate those in the field to seek better, higher-resolution time-frequency decompositions. We have deliberately avoided the question of whether the radial Gaussian kernel adopted in this paper is the most appropriate for decomposing S1 in timefrequency, instead, we have preferred to focus on the mechanics of the first heart sound generation, in doing so, we have created the first computational model to account for fluid-structure interaction in mitral mechanics and the first model, consequently, to predict the non-stationary character of the sound associated with mitral valve closure.…”