Time evolution of the thermotropic behavior of spontaneous liposomes and disks of the DMPC–DTAC aqueous system

Viseu, Maria Isabel; Correia, Raquel F.; Fernandes, Anabela C.

doi:10.1016/j.jcis.2010.06.061

Cited by 18 publications

(16 citation statements)

References 38 publications

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“…Drug release from liposomes has been reported to be determined by the mobility of the phospholipid tails in the lipid bilayer, which is affected strongly by ambient temperature . The phospholipid tails usually tend to move intensively with increasing temperature and transfer from gel to liquid crystal at the phase transition temperature T c . Generally, the T c values are in the range 20–70 °C depending on the kind and mixing ratio of the lipids.…”

Section: Resultssupporting

confidence: 91%

“…Recently, liposome has been widely used in the area of drug delivery because of its particular bilayer vesicle structure, which enables it to encapsulate both hydrophilic and hydrophobic drugs in its hydrophilic core and hydrophobic interlayer, respectively. Besides some basal studies on their thermal/pH stabilities and diameter‐controlling in vitro , liposomes can also be functionalized by grafting specific reagents such as biopolymers, antibodies or cytokines for various delivery targets. For example, PEG‐linked liposomes could avoid being captured by the reticuloendothelial system (RES) and increase the circulation time in the blood .…”

Section: Introductionmentioning

confidence: 99%

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Preparation of a gel‐coated liposome and its application in drug release

Chen

et al. 2012

J of Chemical Tech & Biotech

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BACKGROUND: In some disease therapy, it is necessary to release multiple drugs continuously and orderly. This paper describes a technique for preparing a microparticle that can load two kinds of substances and release them at two different rates. RESULTS:A core-shell structural microparticle was designed using liposome as core and hyaluronan/poly(N-iso propylacrylamide) (HA/PNIPAM) gel as shell. The core liposome keeps its vesicle structure after undergoing the whole crosslinking process. The microparticles are injectable at room temperature and become sticky when heated. The fluorescent loaded in the shell released 80% in 1 h, while that in the core kept releasing for 35 h. CONCLUSION:The stability and function of liposomes are improved after being coated with a gel shell. Two kinds of fluorophores were successfully loaded into microparticles and released at two different rates. The main factors controlling the tracer diffusion are the microparticle properties, e.g. crosslink density and shell thickness. These microparticles can be used as injectable or implantable drug carriers by minimally invasive techniques. CONCLUSIONWe have described a technique for designing a novel core-shell structured microparticle using HSPC-Chol liposome and HA/PNIPAM gel as core and shell, respectively. The stability wileyonlinelibrary.com/jctb

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Section: Resultssupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Preparation of a gel‐coated liposome and its application in drug release

Chen

et al. 2012

J of Chemical Tech & Biotech

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“…The bimodal distributions seen at X C = 0.1-0.5 indicate the coexistence of liposomes and bicelles. Such coexistence has also been reported in the DMPC-DTAC system [10] and in the egg lecithin-Tween 80 system [12]. During the sample preparation process, the XC = 1 sample appeared transparent even before ultrasonication, suggesting spontaneous formation of micelles.…”

Section: Particle Size In the Aqueous Sl-cheo10 Systemsupporting

confidence: 71%

“…A bicelle has a flat bilayer disk with a rim, which is mainly formed by long-chain phospholipids and hydrophilic cosurfactants, respectively [8]. Alternative formulations of bicelles are also possible by mixtures of phospholipids and hydrophilic cosurfactants such as cholesterol sulfate [9], dodecyltrimethylammonium chloride (DTAC) [10], and polyoxyethylene sorbitan monooleate (Tween 80) [11,12]. Nonionic surfactants, such as Tween 80, which has much lower critical micelle concentrations than short-chain phospholipids or other ionic cosurfactants, are beneficial for their resistance to dilution as well as for efficient bicelle formulation.…”

Section: Introductionmentioning

confidence: 99%

Formulation of Bicelles Based on Lecithin-Nonionic Surfactant Mixtures

et al. 2020

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Bicelles have been intensively studied for use as drug delivery carriers and in biological studies, but their preparation with low-cost materials and via a simple process would allow their use for other purposes as well. Herein, bicelles were prepared through a semi-spontaneous method using a mixture of hydrogenated soybean lecithin (SL) and a nonionic surfactant, polyoxyethylene cholesteryl ether (ChEO10), and then we investigated the effect of composition and temperature on the structure of bicelles, which is important to design tailored systems. As the fraction of ChEO10 (XC) was increased, a bimodal particle size distribution with a small particle size of several tens of nanometers and a large particle size of several hundred nanometers was obtained, and only small particles were observed when XC ≥ 0.6, suggesting the formation of significant structure transition (liposomes to bicelles). The small-angle neutron scattering (SANS) spectrum for these particles fitted a core-shell bicelle model, providing further evidence of bicelle formation. A transition from a monomodal to a bimodal size distribution occurred as the temperature was increased, with this transition taking place at lower temperatures when higher SL-ChEO10 concentrations were used. SANS showed that this temperature-dependent size change was reversible, suggesting the SL-ChEO10 bicelles were stable against temperature, hence making them suitable for several applications.

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“…The dynamics of solubilization 19,20 have not been investigated fully, although the equilibrated state has been well studied. While the microscopic observation of each liposome solubilization has been reported, 21,22 all of these studies found that the liposomes were solubilized uniformly; in addition, typically only the solubilization time was evaluated.…”

Section: Introductionmentioning

confidence: 99%