Time estimation circadian rhythm in shift workers and diurnally active humans

Pati, Atanu Kumar; Gupta, Surbhi

doi:10.1007/bf02716822

Cited by 28 publications

(24 citation statements)

References 8 publications

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“…(e.g., Kuriyama et al, 2005;Lustig and Meck, 1991). Consistent with this finding, a circadian rhythm in time estimates was documented in control subjects, but it was found to be disrupted in shift workers (Pati and Gupta, 1994). Moreover, rats exhibit circadian variations in time perception similar to those that have been demonstrated in humans (Shurtleff et al, 1990).…”

Section: Introductionsupporting

confidence: 68%

“…Current evidence suggests that the pacemaker or internal clock which mediates the perception of short durations is sensitive to temperature, attention, emotions, drug and diet manipulations (e.g., Wearden and Penton-Voak, 1995;Cheng et al, 2006;Droit-Volet and Meck, 2007), all of which can be modulated by circadian rhythms. Although the suprachiasmatic nuclei appear to be unnecessary for interval timing (Lewis et al, 2003), time of day effects have been observed for the timing of auditory and visual signals in the seconds-to-minutes range (Aschoff, 1985;Chandrashekaran et al, 1991;Pati and Gupta, 1994;Meck, 1991). For example, several studies have shown that time judgments in humans covary with normal circadian rhythms.…”

Section: Introductionmentioning

confidence: 99%

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Circadian modulation of interval timing in mice

et al. 2011

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Temporal perception is fundamental to environmental adaptation in humans and other animals. To deal with timing and time perception, organisms have developed multiple systems that are active over a broad range of order of magnitude, the most important being circadian timing, interval timing and millisecond timing. The circadian pacemaker is located in the suprachiasmatic nuclei (SCN) of the hypothalamus, and is driven by a selfsustaining oscillator with a period close to 24 h. Time estimation in the second-to-minutes range -known as interval timing -involves the interaction of the basal ganglia and the prefrontal cortex. In this work we tested the hypothesis that interval timing in mice is sensitive to circadian modulations. Animals were trained following the peak-interval (PI) procedure. Results show significant differences in the estimation of 24-second intervals at different times of day, with a higher accuracy in the group trained at night, which were maintained under constant dark (DD) conditions. Interval timing was also studied in animals under constant light (LL) conditions, which abolish circadian rhythmicity. Mice under LL conditions were unable to acquire temporal control in the peak interval procedure.Moreover, short time estimation in animals subjected to circadian desynchronizations (modeling jet lag-like situations) was also affected. Taken together, our results indicate that short-time estimation is modulated by the circadian clock.© 2010 Elsevier B.V. All rights reserved. Keywords:Circadian rhythms Interval timingBasal ganglia Suprachiasmatic nuclei IntroductionTiming and time perception are fundamental to survival and goal reaching in humans and other animals. Organisms have developed diverse mechanisms for timing across different scales, the most important being circadian timing, interval timing and millisecond timing . The circadian pacemaker -which is driven by a self-sustaining oscillator with a period close to 24 h -is located in the suprachiasmatic nuclei (SCN) of the hypothalamus (Dunlap et al., 2004), and the principal signal that adjusts its activity is the light-dark cycle (Morin and Allen, 2006;Golombek and Rosenstein, 2010). The molecular mechanism of the endogenous circadian clock is comprised by interlocked transcription-translation feedback loops (Reppert and Weaver, 2002). On the other hand, the perception of shorter durations in the seconds-to-minutes range, known as interval timing, is crucial to learning, memory, decision making and other cognitive

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Section: Introductionsupporting

confidence: 68%

Section: Introductionmentioning

confidence: 99%

Circadian modulation of interval timing in mice

et al. 2011

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“…For example, several studies have shown that time judgements in humans covary with normal circadian rhythms [127,128]. Consistent with this finding, a circadian rhythm in time estimates was documented in control subjects, but it was found to be disrupted in shift workers [125]. Moreover, rats exhibit circadian variations in time perception similar to those that have been demonstrated in humans [129].…”

Section: Circadian Clocks and Interval Timing: As Time Goes Bysupporting

confidence: 54%

Minutes, days and years: molecular interactions among different scales of biological timing

Golombék

Bussi

Agostino

2014

Phil. Trans. R. Soc. B

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Biological clocks are genetically encoded oscillators that allow organisms to keep track of their environment. Among them, the circadian system is a highly conserved timing structure that regulates several physiological, metabolic and behavioural functions with periods close to 24 h. Time is also crucial for everyday activities that involve conscious time estimation. Timing behaviour in the second-to-minutes range, known as interval timing, involves the interaction of cortico-striatal circuits. In this review, we summarize current findings on the neurobiological basis of the circadian system, both at the genetic and behavioural level, and also focus on its interactions with interval timing and seasonal rhythms, in order to construct a multi-level biological clock.

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“…While the current study examined whether expression of the Clock gene is necessary for interval timing, it did not address whether rhythmicity in the circadian clock is necessary. Although our findings do not suggest a direct molecular link between circadian and interval timing, a number of studies reveal interval timing is modulated by circadian timing (e.g., Aschoff, 1984Aschoff, , 1998Meck, 1991;Pati and Gupta, 1994;Shurtleff et al, 1990). Future studies may wish to look at interval-timing behavior in these animals under arrhythmic conditions to examine the relationship between circadian rhythmicity and regular interval timing.…”

Section: Discussionmentioning

confidence: 55%

“…The circadian clock and the interval timer are used in complementary ways to time the anticipation of the next feeding opportunity (e.g., Crystal, 2001Crystal, , 2003Crystal, , 2006Crystal and Baramidze, 2007;Terman et al, 1984) as well as the amount of time that a female ringdove spends sitting on its nest and when it is time for the male ringdove to take over (Gibbon, Morrell, and Silver, 1984;Silver and Bittman, 1984). The duration with which both rats and humans reproduce short temporal intervals (seconds to minutes) varies with the circadian cycle (Aschoff, 1998;Pati and Gupta, 1994;Shurtleff, Raslear, & Simmons, 1990) while the allocation of attentional control to the durations of auditory and visual stimuli covary as a function of the age of the subjects and circadian phase (Lustig and Meck, 2001 -see also Meck, 1991). Temporal memory for the delivery of food following signal durations between 20 and 60 s are sensitive to photoperiodic variation in laboratory rats in a manner similar to that previously observed for reproductive function (MacDonald et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Intact interval timing in circadian CLOCK mutants

Cordes

Gallistel

2008

Brain Research

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While progress has been made in determining the molecular basis for the circadian clock, the mechanism by which mammalian brains time intervals measured in seconds to minutes remains a mystery. An obvious question is whether the interval timing mechanism shares molecular machinery with the circadian timing mechanism. In the current study, we trained circadian CLOCK +/− and −/ − mutant male mice in a peak-interval procedure with 10 and 20-s criteria. The mutant mice were more active than their wild-type littermates, but there were no reliable deficits in the accuracy or precision of their timing as compared with wild-type littermates. This suggests that expression of the CLOCK protein is not necessary for normal interval timing.

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Time estimation circadian rhythm in shift workers and diurnally active humans

Cited by 28 publications

References 8 publications

Circadian modulation of interval timing in mice

Circadian modulation of interval timing in mice

Minutes, days and years: molecular interactions among different scales of biological timing

Intact interval timing in circadian CLOCK mutants

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