Time-domain optical mammography: initial clinical results on detection and characterization of breast tumors

Grosenick, Dirk; Moesta, K. T.; Wabnitz, Heidrun; Mucke, Jörg; Stroszczynski, Christian; Macdonald, Rainer; Schlag, Peter M.; Rinneberg, H.

doi:10.1364/ao.42.003170

Cited by 184 publications

(151 citation statements)

References 30 publications

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“…This property agreed with the findings from our previous studies, 17,18 and has also been reported in several previous studies using other techniques such as pO 2 measurements 36,37 and near-IR (NIR) diffuse optical spectroscopy. 33,38,39 Malignant breast tissues had an increased mean reduced scattering coefficient compared to that of nonmalignant breast tissues, which is also consistent with the findings from earlier studies published by Peters et al 14 and Ghosh et al 16 Three fluorescence components were extracted from the MCR analysis of the intrinsic fluorescence spectra. The first component (F 1 ) has peak fluorescence at an excitation-emission pair of (340, 395) nm, which coincides with the primary excitation-emission maximum of collagen.…”

Section: Discussionsupporting

confidence: 86%

Diagnosis of breast cancer using fluorescence and diffuse reflectance spectroscopy: a Monte-Carlo-model-based approach

et al. 2008

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We explore the use of Monte-Carlo-model-based approaches for the analysis of fluorescence and diffuse reflectance spectra measured ex vivo from breast tissues. These models are used to extract the absorption, scattering, and fluorescence properties of malignant and nonmalignant tissues and to diagnose breast cancer based on these intrinsic tissue properties. Absorption and scattering properties, including β-carotene concentration, total hemoglobin concentration, hemoglobin saturation, and the mean reduced scattering coefficient are derived from diffuse reflectance spectra using a previously developed Monte Carlo model of diffuse reflectance. A Monte Carlo model of fluorescence described in an earlier manuscript was employed to retrieve the intrinsic fluorescence spectra. The intrinsic fluorescence spectra were decomposed into several contributing components, which we attribute to endogenous fluorophores that may present in breast tissues including collagen, NADH, and retinol/ vitamin A. The model-based approaches removes any dependency on the instrument and probe geometry. The relative fluorescence contributions of individual fluorescing components, as well as β-carotene concentration, hemoglobin saturation, and the mean reduced scattering coefficient display statistically significant differences between malignant and adipose breast tissues. The hemoglobin saturation and the reduced scattering coefficient display statistically significant differences between malignant and fibrous/benign breast tissues. A linear support vector machine classification using (1) fluorescence properties alone, (2) absorption and scattering properties alone, and (3) the combination of all tissue properties achieves comparable classification accuracies of 81 to 84% in sensitivity and 75 to 89% in specificity for discriminating malignant from nonmalignant breast tissues, suggesting each set of tissue properties are diagnostically useful for the discrimination of breast malignancy.

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Section: Discussionsupporting

confidence: 86%

Diagnosis of breast cancer using fluorescence and diffuse reflectance spectroscopy: a Monte-Carlo-model-based approach

et al. 2008

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“…These results are in disagreement with ICG absorption measurements performed by the Physikalisch-Technische Bundesanstalt (PTB, the German National Metrology Institute) [53]. The reverse was found in a larger study including 87 patients [33].…”

Section: Indocyanine Green As a Fluorescence Contrast Agentcontrasting

confidence: 82%

“…Optical imaging has some decisive advantages over established modalities for imaging of the breast: it provides clinically relevant information on the composition of glandular tissue (e.g., fat and water content) and other physiologic information such as hemoglobin content and oxygen saturation [26,33,[100][101][102][103]. The use of light, or low-energy electromagnetic waves, also allows imaging of younger women [104] without exposing them to the risks of ionizing radiation.…”

Section: Discussionmentioning

confidence: 99%

“…To date, most studies published on optical breast imaging used intrinsic contrast [26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45]. Tissue contrasts of hemoglobin, water, and fat and differences in oxygen saturation were investigated.…”

Section: Biophotonicsmentioning

confidence: 99%

“…The breast is slightly compressed between two parallel glass plates or plates made of other material through which light can pass [33,37,59,60]. These plates typically house optical fibers for illumination and light detection.…”

Section: Geometric Designmentioning

confidence: 99%

See 2 more Smart Citations

Near‐infrared imaging of breast cancer using optical contrast agents

Poellinger

2012

Journal of Biophotonics

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Breast cancer is the most common malignancy in women worldwide and the second leading cause of cancer death. On the basis of three studies performed by our group, this article reviews the current status of optical breast imaging using extrinsic contrast agents. To date, only two contrast agents have been applied in human studies, indocyanine green (ICG) and omocianine. Both contrast media were used for absorption and fluorescence imaging. Generally speaking, malignant breast lesions exhibited higher absorption contrast as well as higher fluorescence contrast compared to benign lesions or non‐diseased breast tissue. Some groups consider early enhancement characteristics helpful for differentiation between malignant and benign lesions. Late fluorescence ICG imaging – capitalizing on the extravasation of the dye through the wall of tumorous vessels – seems to be a promising technique to distinguish malignant from benign breast lesions. (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)

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Diffuse Optical Tomography

Wang¹,

Wu²

2009

Biomedical Optics

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Most of all, I would like to thank volunteers and patients who participated in our clinical measurements for their generosity and courage towards developing research for the good of future generation.Lastly, I'd like to thank all my family and friends who have shaped who I am now. Among my friends, I single out devoted friends who were there for me throughout my graduate years. Marky, Saurav, Turgut and I formed a society µστ ρ exploring authentic ethnic cuisines from all around the world. Their adventurous spirits towards trying new things made a lot of fond memories. Also, I would like to thank compassionate Eylem for inviting me to dinners when I was too busy to cook while writing this thesis. I would like to thank Jamie for giving me a patient and caring instructions for the flight lessons. Through becoming a pilot, I have learned whole new level of self-control, patience as well as actual piloting skill and came to terms with my own abilities. My parents have always believed in me and supported me. My mother encouraged me to enjoy the moment while trying my best. My father has been the center and driving force for scientific mindset of our family.My brother Yookyung has shared his experties in medical illustrations by creating exceptionally fine illustrations used in my paper and thesis. Also, he has been there for me in my time of hardship along with Yujun and Agnes. I love them all.

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Time-domain optical mammography: initial clinical results on detection and characterization of breast tumors

Cited by 184 publications

References 30 publications

Diagnosis of breast cancer using fluorescence and diffuse reflectance spectroscopy: a Monte-Carlo-model-based approach

Diagnosis of breast cancer using fluorescence and diffuse reflectance spectroscopy: a Monte-Carlo-model-based approach

Near‐infrared imaging of breast cancer using optical contrast agents

Diffuse Optical Tomography

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