The hydroelastic vibrational responses of a large ship sailing in regular and irregular head waves are investigated numerically and experimentally. A 3D time-domain nonlinear hydroelastic mathematical model is established in which the hydrostatic restoring forces and incident wave forces are calculated on the instantaneous wetted hull surface to consider nonlinear effects of the rigid motion and elastic deformation of the hull in harsh waves. Radiation and diffraction wave forces are computed on the mean wetted surface based on the 3D frequency-domain potential flow theory. The slamming loads are calculated by momentum theory and integrated into the hydrodynamic forces. The 1D Timoshenko beam theory is adopted to model the vibrational structural response and is fully coupled with the presented hydrodynamic theory in time-domain to generate the hydroelastic equation of motion. Moreover, self-propelled segmented model tests were conducted in a laboratory wave tank to experimentally investigate the hydroelastic responses of a target ship in regular and irregular head seas. The numerical and experimental results are systemically compared and analyzed, and the established hydroelastic analysis model turns out to be reliable and effective in the prediction of ship hydroelastic responses in waves.Early research efforts mainly focused on 2D theories in which 2D strip theories, linear or nonlinear, are adopted to analyze the hydrodynamics, while the elastic responses of the ship are represented by the modal superposition method [2][3][4]. With the advent and popularization of high-performance computers, 3D hydroelastic analysis gradually captured the attention of the marine community, especially for the cases where the assumptions of the strip method are not appropriately satisfied [5,6]. The fluid flow is modeled by the 3D potential flow theory, and the ship structure is considered using a 1D or 3D finite element (FE) model [7][8][9]. Recently, Computational Fluid Dynamics (CFD) simulation of fluid flow has been incorporated into the methodology of hydroelasticity [10,11], but the immense amount of time required at present hinders the development of this process, and makes it impractical for use in practical engineering applications.Together with the development of a theoretical approach is the experimental investigation. Small scale ship model tests in towing tanks have been widely conducted to study hydroelastic responses, such as vertical motions and bending moments, with the experimental conditions ranging from moderate seas to high seas [12][13][14]. Besides those small scale model tests, large scale model tests and even the full-scale ship tests have been conducted to further enhance the understanding of fluid-structure interaction mechanisms [15][16][17][18]. A benchmark study on the performance of seventeen hydroelastic analysis codes applied to a target containership was carried out [19]. The hydroelastic model experiment of the target containership was conducted to further test each seakeeping code. Comprehensi...