Time domain heart rate variability in Boxer dogs with arrhythmogenic right ventricular cardiomyopathy

Zacché, E.; Assumpção, Thais Cristine Alves de; Corsini, T. B.; Camacho, Aparecido Antônio

doi:10.1590/0103-8478cr20160740

Cited by 3 publications

(6 citation statements)

References 15 publications

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“…The electrode placement area was previously trichotomized, and the skin was cleaned with alcohol. The connections were arranged to approximate leads I, II and III [3,12]. A bandage was applied to the thorax of dogs that wore a vest for storing the digital recording device.…”

Section: Holter Electrocardiography and Timepointsmentioning

confidence: 99%

“…Such a tool has determined from time-domain indices, which is the time period between successive heartbeats obtained through statistical calculations based on R-R intervals [6]. This method may provide relevant data on the ANS of healthy [8][9][10] or infirm animals [11,12]. Also, HRV is used as a marker of performance of executive functions like attention and emotional processing by the prefrontal cortex in human patients [7][8][9][10][11][12][13], and some external factors may influence HRV.…”

Section: Introductionmentioning

confidence: 99%

“…This method may provide relevant data on the ANS of healthy [8][9][10] or infirm animals [11,12]. Also, HRV is used as a marker of performance of executive functions like attention and emotional processing by the prefrontal cortex in human patients [7][8][9][10][11][12][13], and some external factors may influence HRV. For example, HRV measurement may be influenced by circadian rhythm and the environment [6].…”

Section: Introductionmentioning

confidence: 99%

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Effect of a lactate‐guided conditioning program on heart rate variability obtained using 24-Holter electrocardiography in Beagle dogs

et al. 2020

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The dogs' responses to training exercise are seldom monitored using physiological variables, and cardiac autonomic regulation (CAR) is a relevant determinant of endurance-training adaptation. There are studies in the literature establishing that regular exercise could interfere with CAR in dogs, measured by heart rate and vagal-derived indexes of heart-ratevariability (HRV). However, few studies were found using a prescribed training program based on the lactate threshold (LT) to determine HRV by a 24-h Holter analysis. The purpose of this study was to test whether an endurance-training program (ETP) guided individually by LT raises time-domain measures of HRV in healthy Beagle dogs. Twenty dogs were assigned to two groups: control (C) and trained (T). The dogs from group T underwent an incremental exercise test (IET) to determine their LT. Both LT and velocity corresponding to the LT (VLT) was determined by visual inspection. T group performed an eight-week endurance-training program consisting of treadmill runs set to 70-80% of the VLT. Next, dogs from the group T have submitted to IET again. The maximal velocities (Vmax) at which achieved by the trained dogs in both IETs were determined. The group S did not undergo IETs or ETP. HRV was determined by the 24-hour-Holter at rest, before and on the 2˚, 4˚, 6å nd 8˚training weeks. To examine the HR impact on HRV, standard HRV variables were normalized to prevailing HR. VLT and Vmax rose in group T, indicating an improvement of dogs' aerobic and anaerobic capacity. The normalized standard HRV indexes were relatively attenuated since these variables had a reduction in the degree of correlation concerning an average HR. The ETP resulted in decreased resting heart rate and increased timedomain indices, highlighting the log-transformed square root of the mean sum of the

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Section: Holter Electrocardiography and Timepointsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of a lactate‐guided conditioning program on heart rate variability obtained using 24-Holter electrocardiography in Beagle dogs

et al. 2020

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“…HRV parameters in the time domain express the difference between consecutive RR intervals; for example, pNN50 reflects the predominance of vagal action (Bogucki & Noszczyk-Nowak, 2017;Sztajzel, 2004;Zacché et al, 2017), making pNN50 an excellent indicator for assessing the influence of PANS, as in this study. A study in human patients evaluated PANS activity according to pNN50 and found higher values after vagus nerve stimulation (Liu et al, 2017).…”

Section: Discussionmentioning

confidence: 75%

Heart rate variability and quality of life in dogs with mitral valve disease treated with metoprolol

et al. 2021

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Mitral valve disease (MVD) is a progressive disease that can reduce cardiac output. Activation of the sympathetic autonomic nervous system is one of the body's first responses in order to maintain cardiac output, but may have deleterious effects on the cardiovascular system. This study investigated the effect of metoprolol on heart rate variability and quality of life in dogs with severe MVD (stage C, according to the guidelines of the American College of Veterinary Internal Medicine). Eight dogs between nine and thirteen years of age were enrolled and screening tests such as complete blood count, serum biochemistry profile, systolic blood pressure, thoracic radiographs, electrocardiogram, echocardiogram and long-term electrocardiography (24 hours) were performed. The patients were treated with enalapril, furosemide, spironolactone, and pimobendan until considered clinically stable, and metoprolol was then added to the therapy. One month later, all animals were re-assessed. Owners responded to a questionnaire about their dog's quality of life before and after beta-blocker therapy. The value for pNN50 (percentage difference between adjacent N-N intervals more than 50 ms) was significantly higher (P=0.039) after treatment with metoprolol, indicating higher heart rate variability as indicated by the increased parasympathetic component. Furthermore, quality of life was improved in 30% of patients after metoprolol was initiated. The results suggest that treatment with beta-blockers in dogs with stage C MVD may yield additional benefits in comparison to standard CHF treatment.

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“…When looking at animals with VT, only HRme was different from the other parameters, suggesting that elevated HRme (≥112bpm) could be associated with an increased risk of developing VT, although with a poor specificity. Previous studies of HRV in Boxer dogs did not identify a lower HRV in patients with complex and frequent VA (Spier & Meurs 2004b, Zacché et al 2017. Although HRV was not evaluated in relation to syncope in such investigations, Boxer dogs with CHF had a lower HRV (Spier & Meurs 2004a, Haissaguerre et al 2016, Chamas et al 2016.…”

Section: Discussionmentioning

confidence: 86%

Prognostic value of coupling interval, prematurity index and heart rate variability in Boxer dogs

et al. 2019

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Boxer dogs with arrhythmogenic right ventricular cardiomyopathy (ARVC) can experience sudden cardiac death regardless of presence/absence of clinical signs. The aims of this retrospective study were two-fold: 1) to investigate the coupling interval (CI) and prematurity index (PI) of ventricular arrhythmias (VA), and the heart rate variability (HRV) in Boxers, and 2) to evaluate their impact on overall survival time. The first 24-hour Holter 36 client-owned Boxer dogs meeting inclusion/exclusion criteria were evaluated for the number, morphology, site of origin, complexity, CI and PI, of ventricular premature complexes (VPCs), and time domain HRV. The effect on survival was assessed, considering the presence/absence of ventricular tachycardia (VT), and syncope. All-cause mortality was considered as the end-point, with median survival times being obtained by Kaplan-Meier analyses and compared by log-rank test. Polymorphic VPCs were more common in symptomatic dogs than asymptomatic. VPCs in dogs with VT were less premature, due to the influence of heart rate on PI despite comparable CI. The PI and mean heart rate (HRme) were significantly different between VT and non-VT dogs but did not discriminate adequately between groups as standalone tests. Median survival time was shorter in Boxer dogs with VT (463 vs 1645 days, HR: 4.31, P=0.03). The HRV parameters, SDNN and SDANN, were both associated with prognosis. The CI and PI were not demonstrated to be prognostic surrogates in Boxer dogs with VA. HRme≥112bpm is 100% sensitive but only 46% specific for detecting VT in Boxers on the 24-hour Holter. Presence of VT, SDNN≤245ms, or SDANN≤134ms at the time of the first 24-hour Holter was associated with a shorter survival.

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Time domain heart rate variability in Boxer dogs with arrhythmogenic right ventricular cardiomyopathy

Cited by 3 publications

References 15 publications

Effect of a lactate‐guided conditioning program on heart rate variability obtained using 24-Holter electrocardiography in Beagle dogs

Effect of a lactate‐guided conditioning program on heart rate variability obtained using 24-Holter electrocardiography in Beagle dogs

Heart rate variability and quality of life in dogs with mitral valve disease treated with metoprolol

Prognostic value of coupling interval, prematurity index and heart rate variability in Boxer dogs

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