Time-Domain Fluorescence Spectroscopy Using Time-Correlated Single-Photon Counting

Birch, David J. S.; Imhof, Robert E.

doi:10.1007/0-306-47057-8_1

Cited by 96 publications

(118 citation statements)

References 129 publications

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“…Alternatives to enzymes, including artificial glucose "receptors," as glucose-recognition molecules are being developed (151,152 ). Fluorescence technologies include the use of engineered molecules that exhibit altered fluorescence intensity or spectral characteristics on binding glucose, or the use of competitive-binding assays that use 2 fluorescent molecules in the fluorescent resonance energy transfer technique (153)(154)(155)(156)(157).…”

Section: Analytical Considerationsmentioning

confidence: 99%

Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus

et al. 2011

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BACKGROUND Multiple laboratory tests are used to diagnose and manage patients with diabetes mellitus. The quality of the scientific evidence supporting the use of these tests varies substantially. APPROACH An expert committee compiled evidence-based recommendations for the use of laboratory testing for patients with diabetes. A new system was developed to grade the overall quality of the evidence and the strength of the recommendations. Draft guidelines were posted on the Internet and presented at the 2007 Arnold O. Beckman Conference. The document was modified in response to oral and written comments, and a revised draft was posted in 2010 and again modified in response to written comments. The National Academy of Clinical Biochemistry and the Evidence Based Laboratory Medicine Committee of the AACC jointly reviewed the guidelines, which were accepted after revisions by the Professional Practice Committee and subsequently approved by the Executive Committee of the American Diabetes Association. CONTENT In addition to long-standing criteria based on measurement of plasma glucose, diabetes can be diagnosed by demonstrating increased blood hemoglobin A1c (Hb A1c) concentrations. Monitoring of glycemic control is performed by self-monitoring of plasma or blood glucose with meters and by laboratory analysis of Hb A1c. The potential roles of noninvasive glucose monitoring, genetic testing, and measurement of autoantibodies, urine albumin, insulin, proinsulin, C-peptide, and other analytes are addressed. SUMMARY The guidelines provide specific recommendations that are based on published data or derived from expert consensus. Several analytes have minimal clinical value at present, and their measurement is not recommended.

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Section: Analytical Considerationsmentioning

confidence: 99%

Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus

et al. 2011

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“…Fluorescence was collected at right angles, polarized at magic angle, dispersed in a 0.22 meter single monochromator and detected by a multichannel-plate detector. Single-photon events were timed with standard electronics 23 to yield fluorescence decay data at 12 wavelengths. The typical instrument response function was 45 ps FWHM.…”

Section: Time-resolved Spectroscopymentioning

confidence: 99%

Ultrafast Dynamics in DNA: “Fraying” at the End of the Helix

et al. 2006

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The dynamics of the electric fields in the interior of DNA are measured by using oligonucleotides in which a native base pair is replaced by a dye molecule (coumarin 102) whose emission spectrum is sensitive to the local electric field. Time-resolved measurements of the emission spectrum have been extended to a six decade time range (40 fs to 40 ns) by combining results from time-correlated photon counting, fluorescence up-conversion and transient absorption. Recent results showed that when the reporter is placed in the center of the oligonucleotide, the dynamics are very broadly distributed over this entire time range and do not show specific time constants associated with individual processes [J. Am. Chem. Soc. 2005, 127, 7270]. This paper examines an oligonucleotide with the reporter near its end. The broadly distributed relaxation seen before remains with little attenuation. In addition, a new relaxation with a well defined relaxation time of 5 ps appears. This process is assigned to the rapid component of "fraying" at the end of the helix.

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“…timing accuracy) of the instrument used for the measurement. The temporal full width at half maximum (FWHM) of the IRF t IRF ∆ is given by [43] …”

Section: It P T T T I T T P T T I Pmentioning

confidence: 99%

Wide-field TCSPC: methods and applications

Hirvonen

Suhling

2016

Meas. Sci. Technol.

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Time-Domain Fluorescence Spectroscopy Using Time-Correlated Single-Photon Counting

Cited by 96 publications

References 129 publications

Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus

Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus

Ultrafast Dynamics in DNA: “Fraying” at the End of the Helix

Wide-field TCSPC: methods and applications

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