Time dependent subthalamic local field potential changes after DBS surgery in Parkinson's disease

Rosa, Manuela; Marceglia, Sara; Servello, Domenico; Foffani, Guglielmo; Rossi, Lorenzo; Sassi, Marco; Mrakic‐Sposta, Simona; Zangaglia, Roberta; Pacchetti, Claudio; Porta, Mauro; Priori, Alberto

doi:10.1016/j.expneurol.2009.12.013

Cited by 78 publications

(72 citation statements)

References 41 publications

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“…Beta-band oscillations were present in normal monkeys and their power was EEG state dependent, linked with arousal as well as movement and reward during a simple saccade task. In other observations performed in PD patients who had undergone DBS therapy, the LFP pattern was variable and linked to the electrode impedance (Rosa et al, 2010).…”

Section: Discussionmentioning

confidence: 78%

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Acute inactivation of the medial forebrain bundle imposes oscillations in the SNr: A challenge for the 6-OHDA model?

Galati

D′Angelo

Olivola

et al. 2010

Experimental Neurology

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It has been recently shown that the substantia nigra pars reticulata (SNr) of 6-hydroxydopamine (6-OHDA)-lesioned rats, under urethane anaesthesia, manifests a prominent low frequency oscillation (LFO) of around 1 Hz, synchronized with cortical slow wave activity (SWA). Nevertheless, it is poorly understood whether these electrophysiological alterations are correlated only with severe dopamine depletion or may also play a relevant pathogenetic role in the early stages of the dopamine denervation. Hence, here we recorded SNr single units and electrocorticogram (ECoG) in two models of dopamine denervation: (i) acute dopamine denervated rats, obtained by injection of tetrodotoxin (TTX), (ii) chronic dopamine depleted rats, 2 weeks after 6-OHDA lesioning. Both TTX and 6-OHDA were infused into the medial forebrain bundle (MFB). The acute TTX-mediated dopamine depletion caused a fast developing occurrence of a SNr/ECoG coherence, peaking between 0.48 and 1.22 Hz, parallel with a consistent decrease of firing rate (from 22.61 ± 7.04 to 15.35 ± 9.04 Hz) homolateraly to the infusion. Strikingly, this abnormal 1 Hz synchronization, TTX-mediated was qualitatively similar to the ECoG/SNr synchronization detectable in the 6-OHDA lesioned hemisphere (LH). In addition, TTX infusion in the un-lesioned hemispheres (UH) of 6-OHDA treated rats, produced ECoG/SNr synchronization qualitatively similar to that recordable in the LH. Hence, our data support the proposition that LFO, is tightly correlated to cortex, and represent a critical hallmark of a basal ganglia (BG) failure from the early stages of dopamine denervation.

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Section: Discussionmentioning

confidence: 78%

“…Moreover, beta activity in local field potentials of the striatum could be expressed in normal behaving monkeys (Courtemanche et al, 2003) or variously expressed, even amongst PD patients (Rosa et al, 2010). Hence, the relevance and pathogenetic role of specific rhythms is far from fully established.…”

Section: Introductionmentioning

confidence: 99%

Acute inactivation of the medial forebrain bundle imposes oscillations in the SNr: A challenge for the 6-OHDA model?

Galati

D′Angelo

Olivola

et al. 2010

Experimental Neurology

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“…A subsequent study then investigated the time-dependent STN LFP changes after DBS surgery in PD, and provided new evidence showing that DBS macroelectrode impedance and STN LFP patterns are a function of the time elapsing between macroelectrode implantation and LFP recording [22] . The time course of macroelectrode impedance is related to changes in the electrode/tissue interface and in the STN LFP low-frequency activity.…”

Section: Introductionmentioning

confidence: 99%

Subthalamic Local Field Beta Oscillations during Ongoing Deep Brain Stimulation in Parkinson’s Disease in Hyperacute and Chronic Phases

et al. 2011

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In the past years, local field potential (LFP) signals recorded from the subthalamic nucleus (STN) in patients undergoing deep brain stimulation (DBS) for Parkinson’s disease (PD) disclosed that DBS has a controversial effect on STN beta oscillations recorded 2–7 days after surgery for macroelectrode implantation. Nothing is known about these DBS-induced oscillatory changes 30 days after surgery. We recorded STN LFPs during ongoing DBS in 7 patients with PD, immediately (hyperacute phase) and 30 days (chronic phase) after surgery. STN LFP recordings showed stationary intranuclear STN beta LFP activity in hyperacute and chronic phases, confirming that beta peaks were also present in chronic recordings. Power spectra of nuclei with significant beta activity (54% of the sample) showed that it decreased significantly during DBS (p = 0.021) under both recording conditions. The time course of beta activity showed more evident DBS-induced changes in the chronic than in the hyperacute phase (p = 0.014). DBS-induced changes in STN beta LFPs in patients undergoing DBS in chronic phase provide useful information for developing a new neurosignal-controlled adaptive DBS system.

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“…Electrode impedance increases 30 days after surgery linearly correlating with LF power increases [37]. Hence, in the chronic condition, the LF modulations would be even more pronounced and, in turn, as the time elapsing after DBS surgery lengthens, LF power could be even more pronounced and useful as a control signal.…”

Section: Discussionmentioning

confidence: 99%

“…Impedance in the recording contact pair was evaluated through an impedance meter at 30 Hz (Model EZM 4, Grass Technologies, West Warwick, R.I., USA) before the recording session [37]. For electrical stimulation we used a constant voltage stimulator (Dual Screen, Medtronic) and DBS was delivered with a pulse width of 60 µs, frequency of 130 Hz and intensity previously tested as the optimal stimulation.…”

Section: Methodsmentioning

confidence: 99%

The Effects of Levodopa and Deep Brain Stimulation on Subthalamic Local Field Low-Frequency Oscillations in Parkinson's Disease

et al. 2013

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New adaptive systems for deep brain stimulation (DBS) could in the near future optimize stimulation settings online so as to achieve better control over the clinical fluctuations in Parkinson's disease (PD). Local field potentials (LFPs) recorded from the subthalamic nucleus (STN) in PD patients show that levodopa and DBS modulate STN oscillations. Because previous research has shown that levodopa and DBS variably influence beta LFP activity (8-20 Hz), we designed this study to find out how they affect low-frequency (LF) oscillations (2-7 Hz). STN LFPs were recorded in 19 patients with PD during DBS, after levodopa medication, and during DBS and levodopa intake combined. We investigated the relationship between LF modulations, DBS duration and levodopa intake. We also studied whether LF power depended on disease severity, the patient's clinical condition and whether LF modulations were related to electrode impedances. LF power increased during DBS, after levodopa intake and under both experimental conditions combined. The LF power increase correlated with the levodopa-induced clinical improvement and the higher the electrode impedance, the greater was the LF power change. These data suggest that the LF band could be useful as a control neurosignal for developing novel adaptive DBS systems for patients with PD.

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Time dependent subthalamic local field potential changes after DBS surgery in Parkinson's disease

Cited by 78 publications

References 41 publications

Acute inactivation of the medial forebrain bundle imposes oscillations in the SNr: A challenge for the 6-OHDA model?

Acute inactivation of the medial forebrain bundle imposes oscillations in the SNr: A challenge for the 6-OHDA model?

Subthalamic Local Field Beta Oscillations during Ongoing Deep Brain Stimulation in Parkinson’s Disease in Hyperacute and Chronic Phases

The Effects of Levodopa and Deep Brain Stimulation on Subthalamic Local Field Low-Frequency Oscillations in Parkinson's Disease

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