Time-dependent metabolic disorders induced by short-term exposure to polystyrene microplastics in the Mediterranean mussel Mytilus galloprovincialis

Cappello, Tiziana; Marco, Giuseppe De; Conti, Gea Oliveri; Giannetto, Alessia; Ferrante, Margherita; Mauceri, Angela; Maisano, Maria

doi:10.1016/j.ecoenv.2020.111780

Cited by 78 publications

(30 citation statements)

References 44 publications

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“…The different expression changes of glycine also suggest that they are a defense mechanism against Cd-induced oxidative stress. Similar results to this study were also reported in the digestive glands of mussels exposed to microplastics and petroleum pollutants ( Fasulo et al, 2012 ; Cappello et al, 2021 ). Ji et al (2016) reported that Cd modulated the expression of glycine, proline, and tyrosine in shrimp and Zhang et al (2011) reported that the expression of branched chain amino acids in the gill tissues of clams increased following a 96-h exposure to Cd, indicating impairment of osmotic regulation.…”

Section: Discussionsupporting

confidence: 92%

Metabolomic Alterations in the Digestive System of the Mantis Shrimp Oratosquilla oratoria Following Short-Term Exposure to Cadmium

Liu

Han

et al. 2021

Front. Physiol.

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Mantis shrimp Oratosquilla oratoria is an economically critical aquatic species along the coast of China but strongly accumulates marine pollutant cadmium (Cd) in its digestive system. It is necessary to characterize the toxicity of Cd in the digestive system of mantis shrimp. The metabolic process is an essential target of Cd toxicity response. In this work, we used ultra-performance liquid chromatography coupled with time-of-flight mass spectrometry (UPLC-TOF-MS) for untargeted metabolomics to characterize the metabolic changes in the digestive system of O. oratoria, exposed to 0.05 mg/L for 96 h. The aim of this study was to further investigate the effect of O. oratoria on Cd response to toxicity and develop biomarkers. Metabolomics analysis showed the alteration of metabolism in the digestive system of mantis shrimp under Cd stress. A total of 91 metabolites were differentially expressed and their main functions were classified into amino acids, phospholipids, and fatty acid esters. The enrichment results of differential metabolite functional pathways showed that biological processes such as amino acid metabolism, transmembrane transport, energy metabolism, and signal transduction are significantly affected. Based on the above results, the Cd-induced oxidative stress and energy metabolism disorders were characterized by the differential expression of amino acids and ADP in mantis shrimp, while the interference of transmembrane transport and signal transduction was due to the differential expression of phospholipids. Overall, this work initially discussed the toxicological response of Cd stress to O. oratoria from the metabolic level and provided new insights into the mechanism.

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Section: Discussionsupporting

confidence: 92%

Metabolomic Alterations in the Digestive System of the Mantis Shrimp Oratosquilla oratoria Following Short-Term Exposure to Cadmium

Liu

Han

et al. 2021

Front. Physiol.

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“…To extract polar metabolites, a “two-step” methanol/chloroform/water procedure [ 20 , 21 , 22 ] was applied to the frozen fish gill and liver tissue of 150 and 100 mg weight, respectively. The tissue samples were homogenized in cold methanol (4 mL/g) and cold water (0.85 mL/g) by a TissueLyser LT bead mill (Qiagen, Hilden, Germany) for 10 min at 50 vibrations/s.…”

Section: Methodsmentioning

confidence: 99%

Organ-Specific Metabolome Deciphering Cell Pathways to Cope with Mercury in Wild Fish (Golden Grey Mullet Chelon auratus)

Brandão

Pereira

Pacheco

et al. 2021

Animals

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Metabolomics is a powerful approach in evaluating the health status of organisms in ecotoxicological studies. However, metabolomics data reflect metabolic variations that are attributable to factors intrinsic to the environment and organism, and it is thus crucial to accurately evaluate the metabolome of the tissue/organ examined when it is exposed to no stressor. The metabolomes of the liver and gills of wild golden grey mullet (Chelon auratus) from a reference area were analyzed and compared by proton nuclear magnetic resonance (1H NMR)-based metabolomics. Both organs were characterized by amino acids, carbohydrates, osmolytes, nucleosides and their derivatives, and miscellaneous metabolites. However, similarities and differences were revealed in their metabolite profile and related to organ-specific functions. Taurine was predominant in both organs due to its involvement in osmoregulation in gills, and detoxification and antioxidant protective processes in liver. Environmental exposure to mercury (Hg) triggered multiple and often differential metabolic alterations in fish organs. Disturbances in ion-osmoregulatory processes were highlighted in the gills, whereas differential impairments between fish organs were pointed out in energy-producing metabolic pathways, protein catabolism, membrane stabilization processes, and antioxidant defense system, reflecting the induction of organ-specific adaptive and defensive strategies. Overall, a strict correlation between metabolites and organ-specific functions of fish gills and liver were discerned in this study, as well as organ-specific cytotoxicity mechanisms of Hg in fish.

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“…3 and Online Resource 1 for time-lapse movie), which have become a world-wide concern. Since early reports about microplastic contamination in mussels (Browne et al 2008;von Moos et al 2012;Wegner et al 2012), an increasing number of papers have been published, mainly on species of Mytilus and Perna (Chae and An 2020; Gedik and Eryasar 2020; Kazour and Amara 2020; Piarulli and Airoldi 2020; Christoforou et al 2020;Cole et al 2020;Li et al 2020a;Stamataki et al2020;Wakkaf et al 2020;Webb et al 2020;Alnajar et al 2021;Cappello et al 2021;Cho et al 2021;Klasios et al 2021;Kumar et al 2021;Liu et al 2021;Perez et al 2021;Seuront et al 2021;Wang et al 2021a,b). Considering their distributions around cities and other human habitations, mussels are ideal organisms for monitoring microplastic pollution.…”

Section: Ingestion Of Microplasticsmentioning

confidence: 99%

Mussel biology: from the byssus to ecology and physiology, including microplastic ingestion and deep-sea adaptations

2021

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Mussels are a group of bivalves that includes the dominant species of shallow-sea, freshwater, and deep-sea chemosynthetic ecosystems. Mussels cling to various solid underwater surfaces using a proteinaceous thread, called the byssus, which is central to their ecology, physiology, and evolution. Mussels cluster using their byssi to form “mussel beds,” thereby increasing their biomass per unit of habitat area, and also creating habitats for other organisms. Clustered mussels actively filter feed to obtain nutrients, but also ingest pollutants and suspended particles; thus, mussels are good subjects for pollution analyses, especially for microplastic pollution. The byssus also facilitates invasiveness, allowing mussels to hitchhike on ships, and to utilize other man-made structures, including quay walls and power plant inlets, which are less attractive to native species. Physiologically, mussels have adapted to environmental stressors associated with a sessile lifestyle. Osmotic adaptation is especially important for life in intertidal zones, and taurine is a major component of that adaptation. Taurine accumulation systems have also been modified to adapt to sulfide-rich environments near deep-sea hydrothermal vents. The byssus may have also enabled access to vent environments, allowing mussels to attach to “evolutionary stepping stones” and also to vent chimneys.

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Time-dependent metabolic disorders induced by short-term exposure to polystyrene microplastics in the Mediterranean mussel Mytilus galloprovincialis

Cited by 78 publications

References 44 publications

Metabolomic Alterations in the Digestive System of the Mantis Shrimp Oratosquilla oratoria Following Short-Term Exposure to Cadmium

Metabolomic Alterations in the Digestive System of the Mantis Shrimp Oratosquilla oratoria Following Short-Term Exposure to Cadmium

Organ-Specific Metabolome Deciphering Cell Pathways to Cope with Mercury in Wild Fish (Golden Grey Mullet Chelon auratus)

Mussel biology: from the byssus to ecology and physiology, including microplastic ingestion and deep-sea adaptations

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