Time-dependent fate of transplanted neural precursor cells in experimental autoimmune encephalomyelitis mice

Giannakopoulou, Aggeliki; Grigoriadis, Nikolaos; Polyzoidou, Eleni; Lourbopoulos, Athanasios; Michaloudi, Eleni; Papadopoulos, Georgios C.

doi:10.1016/j.expneurol.2010.04.011

Cited by 25 publications

(24 citation statements)

References 41 publications

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“…intrinsic characteristics of the damaged CNS region (Table 1 [ [48][49][50]). As a matter of fact, cell replacement is obtainable via NPC transplantation only in disorders in which degeneration is caused either by intrinsic cellular defects or by extrinsic factors that are no longer active in a specific cell population residing within a discrete CNS area.…”

Section: Key Pointsmentioning

confidence: 99%

Neural stem cell transplantation in central nervous system disorders

Feo

Merlini

Laterza³

et al. 2012

Current Opinion in Neurology

164

105

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Nowadays, the research on NPC transplantation in neurological disorders is advancing on two different fronts: on one hand, recent preclinical data are uncovering the molecular basis of NPC therapeutic plasticity, offering a more solid rational framework for the design of clinical studies. On the other hand, pilot trials are highlighting the safety and feasibility issues of neural stem cell transplantation that need to be addressed before efficacy could be properly evaluated.

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Section: Key Pointsmentioning

confidence: 99%

Neural stem cell transplantation in central nervous system disorders

Feo

Merlini

Laterza³

et al. 2012

Current Opinion in Neurology

164

105

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“…stroke, SCI and MS) transplantation aimed at cell replacement would be useful only during the post-acute phase of the disease (Karimi-Abdolrezaee et al, 2006;Bacigaluppi et al, 2009b) when the inflammatory phase is limited. It is now clear that the immune milieu can influence, either detrimentally or protectively, the fate of transplanted cells (Carpentier and Palmer, 2009;Deverman and Patterson, 2009;Ransohoff, 2009;Giannakopoulou et al, 2011;Muja et al, 2011;Kokaia et al, 2012).…”

Section: Npc Transplantation As a Therapeutic Tool To Promote Brain Rmentioning

confidence: 99%

Brain Repair: The Role of Endogenous and Transplanted Neural Stem Cells

Bacigaluppi¹,

Butti²,

Laterza³

et al. 2014

Neuroinflammation and CNS Disorders

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“…After transplantation, cells either remain undifferentiated or differentiate mainly to the glial cell‐lineage (Aharonowiz et al, ; Ben‐Hur et al, ). Their acquired phenotype may depend on the time point and site of migration (Einstein et al, ; Giannakopoulou et al, ). Although these cells are considered integrated within the host tissue, only one study has indicated the presence of gap junctions (GJs) on these cells so far (Jaderstad et al, ).…”

Section: Introductionmentioning

confidence: 99%

Connexin43 and connexin47 alterations after neural precursor cells transplantation in experimental autoimmune encephalomyelitis

Theotokis

Kleopa

Touloumi

et al. 2015

Glia

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Exogenous transplanted neural precursor cells (NPCs) exhibit miscellaneous immune-modulatory effects in models of autoimmune demyelination. However, the regional interactions of NPCs with the host brain tissue in remissive inflammatory events have not been adequately studied. In this study we used the chronic MOG-induced Experimental Autoimmune Encephalomyelitis (EAE) model in C57BL/six mice. Based on previous data, we focused on neuropathology at Day 50 post-induction (D50) and studied the expression of connexin43 (Cx43) and Cx47, two of the main glial gap junction (GJ) proteins, in relation to the intraventricular transplantation of GFP(+) NPCs and their integration with the host tissue. By D50, NPCs had migrated intraparenchymally and were found in the corpus callosum at the level of the lateral ventricles and hippocampus. The majority of GFP(+) cells differentiated with simple or ramified processes expressing mainly markers of mature GLIA (GFAP and NogoA) and significantly less of precursor glial cells. GFP(+) NPCs expressed connexins and formed GJs around the hippocampus more than lateral ventricles. The presence of NPCs did not alter the increase in Cx43 GJ plaques at D50 EAE, but prevented the reduction of oligodendrocytic Cx47, increased the number of oligodendrocytes, local Cx47 levels and Cx47 GJ plaques per cell. These findings suggest that transplanted NPCs may have multiple effects in demyelinating pathology, including differentiation and direct integration into the panglial syncytium, as well as amelioration of oligodendrocyte GJ loss, increasing the supply of potent myelinating cells to the demyelinated tissue.

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Time-dependent fate of transplanted neural precursor cells in experimental autoimmune encephalomyelitis mice

Cited by 25 publications

References 41 publications

Neural stem cell transplantation in central nervous system disorders

Neural stem cell transplantation in central nervous system disorders

Brain Repair: The Role of Endogenous and Transplanted Neural Stem Cells

Connexin43 and connexin47 alterations after neural precursor cells transplantation in experimental autoimmune encephalomyelitis

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