Time-dependent effects of fructose on the modulation of a reactivated memory

Horne, Claire A. M.; Rodriguez, Ward A.; Wright, Theodore P.; Padilla, James L.

doi:10.1016/s0278-5846(97)00038-9

Cited by 25 publications

(13 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Limited evidence suggests that the end of the reconsolidation window is likely to be around six hours, but the neurobiology of reconsolidation is largely unknown and not allowing estimations about the start of such a window (e.g. Horne, Rodriguez, Wright, & Padilla, 1997; Rodriguez, Horne, & Padilla, 1999; Sara, 2000). In clinical practice and other experimental psychopathology, dual tasks interventions are usually administered during and immediately after memory reactivation (Van den Hout & Engelhard, 2012).…”

Section: Discussionmentioning

confidence: 99%

Tetris and Word games lead to fewer intrusive memories when applied several days after analogue trauma

Hagenaars

Holmes

Klaassen

et al. 2017

European Journal of Psychotraumatology

View full text Add to dashboard Cite

Background: Intrusive trauma memories are a key symptom of posttraumatic stress disorder (PTSD), so disrupting their recurrence is highly important. Intrusion development was hindered by visuospatial interventions administered up to 24 hours after analogue trauma. It is unknown whether interventions can be applied later, and whether modality or working-memory load are crucial factors. Objectives: This study tested: (1) whether a visuospatial task would lead to fewer intrusions compared to a reactivation-only group when applied after memory reactivation four days after analogue trauma exposure (extended replication), (2) whether both tasks (i.e. one aimed to be visuospatial, one more verbal) would lead to fewer intrusions than the reactivation-only group (intervention effect), and (3) whether supposed task modality (visuospatial or verbal) is a critical component (modality effect). Method: Fifty-four participants were randomly assigned to reactivation+Tetris (visuospatial), reactivation+Word games (verbal), or reactivation-only (no task). They watched an aversive film (day 0) and recorded intrusive memories of the film in diary A. On day 4, memory was reactivated, after which participants played Tetris, Word games, or had no task for 10 minutes. They then kept a second diary (B). Informative hypotheses were evaluated using Bayes factors. Results: Reactivation+Tetris and reactivation+Word games resulted in relatively fewer intrusions from the last day of diary A to the first day of diary B than reactivation-only (objective 1 and 2). Thus, both tasks were effective even when applied days after analogue trauma. Reactivation-only was not effective. Reactivation+Word games appeared to result in fewer intrusions than reactivation+Tetris (objective 3; modality effect), but this evidence was weak. Explorative analyses showed that Word games were more difficult than Tetris. Conclusions: Applying a task four days after the trauma film (during memory reconsolidation) was effective. The modality versus working-memory load issue is inconclusive.

show abstract

Section: Discussionmentioning

confidence: 99%

Tetris and Word games lead to fewer intrusive memories when applied several days after analogue trauma

Hagenaars

Holmes

Klaassen

et al. 2017

European Journal of Psychotraumatology

View full text Add to dashboard Cite

show abstract

“…In addition to those studies using protein-synthesis inhibitors (Judge and Quartermain 1982;Nader et al 2000;Anokhin et al 2002;Sangha et al 2003; for review, see Alberini 2005) other studies were performed in order to test the memory reconsolidation hypothesis using blockers of transcription factors and/or immediate early gene expression (Taubenfeld et al 2001;Kida et al 2002;Bozon et al 2003;Lee et al 2004;Merlo et al 2005), inhibitors of kinases (Kelly et al 2003;Koh and Bernstein 2003), or new potential learning situations (Gordon and Spear 1974;Walker et al 2003;Boccia et al 2005), and only a few studies found evidence of enhancement of memory with post-retrieval treatments (De Vietti et al 1977;Horne et al 1997, Rodriguez et al 1999. This is an important issue if we want to compare consolidation vs. reconsolidation memory processes.…”

Section: Discussionmentioning

confidence: 99%

“…It is accepted that once consolidation is completed, memory becomes permanent (Squire and Alvarez 1995). However, it has also been suggested that reactivation (retrieval) of the original memory again makes it sensitive to disruption, since several post-retrieval treatments impair or enhance it (Misanin et al 1968;DeVietti et al 1977;Horne et al 1997;Rodriguez et al 1999;Sara 2000;Nader 2003). This new period of sensitivity coined the term reconsolidation, suggesting the "reconsolidation" hypothesis.…”

mentioning

confidence: 99%

Post-retrieval effects of icv infusions of hemicholinium in mice are dependent on the age of the original memory

Boccia¹,

Blake²,

Acosta³

et al. 2006

Learn. Mem.

View full text Add to dashboard Cite

CF-1 male mice were trained in an inhibitory avoidance task using a high footshock (1,2 mA, 50 Hz, 1 sec) in order to reduce the influence of extinction on retention performance. At 2, 7, 14, or 30 d after training, the first retention test was performed and hemicholinium (HC-3, 1.0 µg/mice), a specific inhibitor of high-affinity choline uptake in brain cholinergic neurons, was given intracerebroventricularly immediately after. Twenty four hours after treatment, mice were tested in an inhibitory avoidance task during five consecutive days, each 24 h apart. Retention performance was impaired by HC-3 when the first re-exposure took place at 2, 7, or 14 d, but the effect was no longer seen when re-exposure occurred 30 d after training. We did not find spontaneous recovery 21 d after training, when memory was retrieved 2 d after training and HC-3 was given immediately after. Although we cannot definitively discard a retrieval deficit, this lack of spontaneous recovery is in accordance with the storage-deficit interpretation. These results confirm and extend previous ones, suggesting that central cholinergic mechanisms are involved in the hypothetical reconsolidation memory processes of an inhibitory avoidance task in mice and also suggest that this participation depends on the "age" of the original memory trace. This implies that the vulnerability of a reactivated memory to a specific treatment, as the one used in this study, inversely correlates with the age of the original memory, and it is likely to determine memory reconsolidation processes.

show abstract

“…In the case of reconsolidation, it is initiated after reactivation of an existing, consolidated memory representation. As is the case for consolidation, only during the reconsolidation phase can memory be enhanced by "memory enhancers" (Gordon 1977b;Rodriguez et al 1993Rodriguez et al , 1999Horne et al 1997), or impaired by either amnesic treatments (Misanin et al 1968) or interference produced by new learning (Gordon 1977a). These treatments are ineffective when reconsolidation is complete, which is also the case for consolidation.…”

Section: Behavioral Evidence For a Reconsolidation Processmentioning

confidence: 99%

Reconsolidation and the Dynamic Nature of Memory

Nader

2015

Cold Spring Harb Perspect Biol

148

View full text Add to dashboard Cite

Memory reconsolidation is the process in which reactivated long-term memory (LTM) becomes transiently sensitive to amnesic agents that are effective at consolidation. The phenomenon was first described more than 50 years ago but did not fit the dominant paradigm that posited that consolidation takes place only once per LTM item. Research on reconsolidation was revitalized only more than a decade ago with the demonstration of reconsolidation in a well-defined behavioral protocol (auditory fear conditioning in the rat) subserved by an identified brain circuit (basolateral amygdala). Since then, reconsolidation has been shown in many studies over a range of species, tasks, and amnesic agents, and cellular and molecular correlates of reconsolidation have also been identified. In this review, I will first define the evidence on which reconsolidation is based, and proceed to discuss some of the conceptual issues facing the field in determining when reconsolidation does and does not occur. Last, I will refer to the potential clinical implications of reconsolidation.

show abstract

Time-dependent effects of fructose on the modulation of a reactivated memory

Cited by 25 publications

References 12 publications

Tetris and Word games lead to fewer intrusive memories when applied several days after analogue trauma

Tetris and Word games lead to fewer intrusive memories when applied several days after analogue trauma

Post-retrieval effects of icv infusions of hemicholinium in mice are dependent on the age of the original memory

Reconsolidation and the Dynamic Nature of Memory

Contact Info

Product

Resources

About