Time-Dependent Changes of Serum Gastrin and Gastrin Receptors in the Rat Oxyntic Mucosa after Proximal Gastric Vagotomy

Reina, A; López-Cantarero, Manuel; Gallardo, A. Colomer; Fuentes, Orlando; Gaitán, Diego; Garcı́a, Ana Maria; González, Cristina; Acuña-Castroviejo, Darı́o

doi:10.1006/jsre.1996.4972

Cited by 1 publication

(1 citation statement)

References 12 publications

(16 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In another animal study, plasma gastrin level rose 12 weeks after the Proximal Gastric Vagotomy (Reina, Lopez-Cantarero et al 1997). In another study, human patients who had had Vagotomy and Pyloroplasty for Peptic ulcer disease had higher plasma gastrin level than pre-operative levels (McGuigan and Trudeau 1972).…”

Section: 7: Discussionmentioning

confidence: 94%

Energy Homeostasis in children with Prader- Willi syndrome

Nyunt¹

View full text Add to dashboard Cite

IntroductionPrader-Willi syndrome (PWS) is a genetic condition commonly associated with hyperphagia and obesity. PWS is thought to have hypothalamic dysfunction which is the head ganglion of autonomic nervous system (ANS). In current literature, ANS is believed to be defective in PWS. ANS may also have a role in controlling orexigenic hormone ghrelin and energy expenditure. One study reported higher resting energy expenditure adjusted for lean body mass in growth hormone naive PWS group but another study found lower activity associated energy expenditure compared to controls. Other studies found adjusted basal and sleeping metabolic rates were not different to the controls. Complete profile of energy expenditure in PWS remains unclear.We hypothesize that there is defective ANS in PWS, as a result of hypothalamus dysfunction, and it leads to high orexigenic hormone, acyl ghrelin, and low energy expenditure that in turn cause obesity. MethodsWe compared the ANS functions, acyl ghrelin status and energy expenditure in children with PWS and controls.We recruited 16 genetically-confirmed children with PWS and 16 controls. Exclusion criteria were diabetes mellitus, psycho-trophic medications, and other hypothalamic pathologies.We performed a mixed meal challenge to assess ANS function and acyl ghrelin status of PWS and control groups. We used Bodystat 1500 ® to measure body composition.Orthostatic hypotension, due to gravity, stimulates baroreceptors and activates sympathetic nervous system to counter regulate postural drop in blood pressure by increasing pulse rate, stroke volume and vasoconstriction. We used orthostatic change in pulse rate (PR), blood pressure (BP), and mean arterial pressure (MAP) expressed as per cent change of PR (%ΔPR), BP (%ΔBP), and MAP (%ΔMAP) from lying to standing to access sympathetic nervous function. ANS was further stimulated by a mixed meal and we examined %ΔPR, %ΔBP, and %ΔMAP at 15 and 30 seconds after standing from recumbent position; at fasting, and post-prandial periods. We also measured plasma gastrin, catecholamines (Pcat) and urinary catecholamines (Ucat) at fasting and postprandial periods to complement autonomic cardiovascular data. Using Actiheart®, we compared weight and fat free mass adjusted total, resting, activity-associated and nonexercise associated thermogenesis between two groups. 3 ResultsPWS group was younger, shorter, and had reduced lean mass than the controls. Postprandial %ΔPR at both 15 and 30 seconds were significantly lower in PWS group than controls. The difference in %Δ systolic BP and diastolic BP did not reach statistical significance but %ΔMAP at 60 min and 120 min after meal was significantly lower in PWS.Postprandial plasma gastrin and Ucat were higher in PWS group than controls but Pcat were not different in two groups. Fasting plasma acyl ghrelin (AG) was significantly higher in PWS but it decreased to similar level of controls at 60 and 120 minutes after a meal.The rate of fall of plasma acyl ghrelin was faster in the PWS group than the ...

show abstract

Section: 7: Discussionmentioning

confidence: 94%

Energy Homeostasis in children with Prader- Willi syndrome

Nyunt¹

View full text Add to dashboard Cite

show abstract

Time-Dependent Changes of Serum Gastrin and Gastrin Receptors in the Rat Oxyntic Mucosa after Proximal Gastric Vagotomy

Cited by 1 publication

References 12 publications

Energy Homeostasis in children with Prader- Willi syndrome

Energy Homeostasis in children with Prader- Willi syndrome

Contact Info

Product

Resources

About