Time-dependent changes in learning ability and induction of long-term potentiation in the lithium–pilocarpine-induced epileptic mouse model

Zhang, Yue; Cai, Guangyan; Yang, Qian; Lü, Qing; Li, Shengtian; Ju, Gong

doi:10.1016/j.yebeh.2010.02.008

Cited by 33 publications

(30 citation statements)

References 58 publications

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“…Even though, we detected that the magnitude of TBS-induced LTP was reduced in epileptic rats. This result is similar to that obtained with electrographic seizures [36], [37], pharmacological induced epileptiform activity [4], [38] and other experimental models such as kindling [3], [6], [39] and pilocarpine injections [23]. In general, impairment of this form of synaptic plasticity has been attributed to seizure related alterations of signalling cascades involved in the modulation of synaptic strength [2], [4], which would occlude or saturate subsequent generation of LTP by electrical stimulation.…”

Section: Discussionsupporting

confidence: 86%

“…These synaptic changes resemble those found in hippocampal CA1 area one day after lithium-pilocarpine injection although 6 weeks later these animals presented LTP impairment [23]. In our study, the increment of LTP magnitude in resistant rats was observed several weeks after kainate treatment, disclosing, thereafter, that these changes were due to the presence of kainate during LTP induction.…”

Section: Discussionsupporting

confidence: 81%

“…This group represents about 20% of our kainate-treated animals. A similar rate of resistant rats has been found with the lithium-pilocarpine model [23]. However, such a percentage contrasts with the success obtained by others using kainate [12] which reported that nearly all treated animals developed status epilepticus .…”

Section: Discussionsupporting

confidence: 63%

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Systemic Injection of Kainic Acid Differently Affects LTP Magnitude Depending on its Epileptogenic Efficiency

et al. 2012

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Seizures have profound impact on synaptic function and plasticity. While kainic acid is a popular method to induce seizures and to potentially affect synaptic plasticity, it can also produce physiological-like oscillations and trigger some forms of long-term potentiation (LTP). Here, we examine whether induction of LTP is altered in hippocampal slices prepared from rats with different sensitivity to develop status epilepticus (SE) by systemic injection of kainic acid. Rats were treated with multiple low doses of kainic acid (5 mg/kg; i.p.) to develop SE in a majority of animals (72–85% rats). A group of rats were resistant to develop SE (15–28%) after several accumulated doses. Animals were subsequently tested using chronic recordings and object recognition tasks before brain slices were prepared for histological studies and to examine basic features of hippocampal synaptic function and plasticity, including input/output curves, paired-pulse facilitation and theta-burst induced LTP. Consistent with previous reports in kindling and pilocapine models, LTP was reduced in rats that developed SE after kainic acid injection. These animals exhibited signs of hippocampal sclerosis and developed spontaneous seizures. In contrast, resistant rats did not become epileptic and had no signs of cell loss and mossy fiber sprouting. In slices from resistant rats, theta-burst stimulation induced LTP of higher magnitude when compared with control and epileptic rats. Variations on LTP magnitude correlate with animals’ performance in a hippocampal-dependent spatial memory task. Our results suggest dissociable long-term effects of treatment with kainic acid on synaptic function and plasticity depending on its epileptogenic efficiency.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionsupporting

confidence: 81%

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Systemic Injection of Kainic Acid Differently Affects LTP Magnitude Depending on its Epileptogenic Efficiency

et al. 2012

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“…On the other hand, emerging evidence has suggested LILRB2/PirB is also involved in synaptic plasticity by inhibiting longterm potentiation (LTP), enhancing long-term depression (LTD), and reducing dendritic spine and excitatory synapse density . Alterations of LTP and LTD have been observed in TLE models as well as in human tissue from epilepsy patients, and may have a significant impact on the occurrence and development of TLE (Kirschstein et al, 2007;Zhang et al, 2010). In addition, changes in dendritic spine density are associated with synaptic plasticity, which is strongly correlated to the pathological basis of epilepsy (Gardiner and Marc, 2010).…”

Section: Lilrb2/pirb In Tlementioning

confidence: 99%

Activation of LILRB2 signal pathway in temporal lobe epilepsy patients and in a pilocarpine induced epilepsy model

Yue

Liang

et al. 2016

Experimental Neurology

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“…Memory deficit due to seizures are not ameliorated with antiepileptic drugs treatment (13) and they may even enhance the reduction. An early and persistent deficit of spatial memory during epileptogenesis was demonstrated in pilocarpine model of temporal lobe epilepsy (14)(15)(16). Further, pentylenetetrazol kindled seizures produced a profound decrease in learning and memory of rat in Morris water maze test (17,18).…”

Section: Introductionmentioning

confidence: 99%

Reversal Effect of Coriandrum sativum Leaves Extract on Learning and Memory Deficits Induced by Epilepsy in Male Rat

Elahdadi-Salmani

Khorshidi

Ozbaki

2015

Zahedan J Res Med Sci

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Background:The extract of Coriandrum Sativum L., commonly known as coriander, belonging to the Apiaceae family (Umbelliferae), is cultivated throughout the world for its nutritional value. C. sativum was shown to enhance cognitive performance and recover memory deficit. On the other hand, epilepsy induces cognitive disorders; learning and memory deficits in different animal models. Thus, the present study was undertaken to investigate the effects of C. sativum on water maze learning and memory of epileptic rats. Materials and Methods:In this experimental study, C. sativum extract was injected intraperitoneally for 7 consecutive days to experimental animals. Pilocarpine was administered (i.p.) to induce epileptic convulsions. Morris water maze (MWM) apparatus served as the behavioral model for testing spatial learning and memory. Latency to locate the platform, swimming distance and velocity were employed as variables in acquisition and probe trials, while crossing and proximity were only used in probe test. Results: The latency and distance to reach the hidden platform increased in pilocarpine treated rats. C. sativum extract decreased the latency and distance to platform compared with control and more prominently compared with epileptic group. Pilocarpine convulsions increased the platform location latency, but C. sativum extract did not reverse this seizure induced latency increase. Conversely, C. sativum extract reversed the seizure induced proximity increase. Conclusion: C. sativum extract may be a useful remedy in the management of epilepsy induced learning and memory impairments.

show abstract

Time-dependent changes in learning ability and induction of long-term potentiation in the lithium–pilocarpine-induced epileptic mouse model

Cited by 33 publications

References 58 publications

Systemic Injection of Kainic Acid Differently Affects LTP Magnitude Depending on its Epileptogenic Efficiency

Systemic Injection of Kainic Acid Differently Affects LTP Magnitude Depending on its Epileptogenic Efficiency

Activation of LILRB2 signal pathway in temporal lobe epilepsy patients and in a pilocarpine induced epilepsy model

Reversal Effect of Coriandrum sativum Leaves Extract on Learning and Memory Deficits Induced by Epilepsy in Male Rat

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