Time Dependence of Elimination of Different PEth Homologues in Alcoholics in Comparison with Social Drinkers

Abstract

In addition to the approach to quantitate the PEth homologue 16:0/18:1, this is a new and alternative proceeding for the differentiation between alcoholics and social drinkers using this alcohol consumption marker.

Quantification of phosphatidylethanol 16:0/18:1, 18:1/18:1, and 16:0/16:0 in venous blood and venous and capillary dried blood spots from patients in alcohol withdrawal and control volunteers

“…Although blood analysis from heavy drinkers shows inter-individual variations of the distribution of the different PEths [6], the predominant species in blood after alcohol consumption are PEth 16:0/18:1 (30-46%) and PEth 16:0/18:2 (16-28%) [5][6][7][8][9]. Other PEths detected are PEth 18:1/18:1 and PEth 18:0/18:2 (identical molecular masses), together accounting for about 11-12% of total PEths [6,7] while PEth 16:0/16:0 accounts for about 5% [6].…”

Direct biomarkers to determine alcohol consumption during pregnancy, which one to use?

“…Of over 40 PEth homologues discovered, 16:0/18:1 (POPEth) is the most abundant one in alcoholics [15]. Further, homologues 16:0/18:2 (PLPEth) and 18:0/18:2 are found frequently as well in both alcoholics and social drinkers [16]. Analysis is best performed by LC-MS/ MS methods and LOQs reported ranges start from 3,1 nmol/L to 30 ng/ml [14,16,17].…”

“…Further, homologues 16:0/18:2 (PLPEth) and 18:0/18:2 are found frequently as well in both alcoholics and social drinkers [16]. Analysis is best performed by LC-MS/ MS methods and LOQs reported ranges start from 3,1 nmol/L to 30 ng/ml [14,16,17]. Research has focused on cut-off levels to differentiate between abstainers, social drinkers and alcoholics [14].…”

“…How positive results should be interpreted remains a difficult issue. The ratio of different PEth homologues might indicate if consumption was very recent or not [16]. To answer this question it might be useful to combine PEth analysis with EtG testing.…”

Thematic Review Series: Phospholipases: Central Role in Lipid Signaling and Disease

“…However, because of a 1,000-fold higher preference for primary alcohols ( 2 ), production of phosphatidylalcohol ( 4 ) is the primary outcome when even relatively modest amounts (1-3%) of ethanol or 1-butanol are present ( 5 ). Phosphatidylethanol (PtdEtOH) has a long half-life relative to ethanol and can be detected in serum for up to a month subsequent to alcohol consumption ( 6 ), making it an increasingly popular biomarker for assessment of acute and even chronic drinking. PtdEtOH can be found at low levels even in nondrinking individuals though, because intestinal bacteria generate small amounts of ethanol through fermentation.…”