Time-Cumulative Toxicity of Neonicotinoids: Experimental Evidence and Implications for Environmental Risk Assessments

Sánchez‐Bayo, Francisco; Tennekes, Henk

doi:10.3390/ijerph17051629

Cited by 41 publications

(18 citation statements)

References 95 publications

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“…The virus concentration and the contact ‘exposure time’ are important. The effect depends on absorbed dose, as was often experimentally verified for toxins 25 . Large droplets with viruses go with the flow and fall on the ground.…”

Section: Risk Increases With Time Speculations On Risk- and Number Tmentioning

confidence: 79%

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Similarities between pandemics and cancer in growth and risk models

Vandamme

Hingh

Fonseca

et al. 2021

Sci Rep

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Cancer and pandemics are leading causes of death globally, with severe socioeconomic repercussions. To better understand these repercussions, we investigate similarities between pandemics and cancer and describe the limited growth in number of infections or cancer cells, using mathematical models. For a pandemic, the analysis shows that in most cases, the initial fast growth is followed by a slower decay in the recovery phase. The risk of infection increases due to the airborne virus contact crossing a risk-threshold. For cancers caused by carcinogens, the increasing risk with age and absorbed dose of toxins that cross a risk-threshold, may lead to the disease onset. The time scales are different for both causes of death: years for cancer development and days to weeks for contact with airborne viruses. Contamination by viruses is on a time scale of seconds or minutes. The risk-threshold to get ill and the number-threshold in cancer cells or viruses, may explain the large variability in the outcome. The number of infected persons per day is better represented in log–lin plots instead of the conventional lin–lin plots. Differences in therapies are discussed. Our mathematical investigation between cancer and pandemics reveals a multifactorial correlation between both fragilities and brings us one step closer to understand, timely predict and ultimately diminish the socioeconomic hurdle of both cancer and pandemics.

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Section: Risk Increases With Time Speculations On Risk- and Number Tmentioning

confidence: 79%

“…‘stress-dose’ × ‘exposure time’ , and age. The absorbed dose has a mechanical (mesothelioma), chemical (toxins) or mental stress origin 25 .…”

Section: Risk Increases With Time Speculations On Risk- and Number Tmentioning

confidence: 99%

Similarities between pandemics and cancer in growth and risk models

Vandamme

Hingh

Fonseca

et al. 2021

Sci Rep

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“…Imidacloprid metabolites may also play a role in flatheaded borer toxicity over time but were not evaluated with the ELISA procedure in this study. Alternatively, the multi-year toxicity against flatheaded borers could be a result of time-cumulative toxicity, where long larval developmental periods of 1−2 yr and extended feeding on lower doses of imidacloprid may have the same effect as a short-interval exposure to a higher dose ( Sánchez-Bayo and Tennekes 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Systemic Imidacloprid and Herbicide Treatments on Flatheaded Borer (Coleoptera: Buprestidae) Management in Field Nursery Production

Addesso

Oliver

Youssef

et al. 2020

Journal of Economic Entomology

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The flatheaded appletree borer, Chrysobothris femorata (Olivier) (Coleoptera: Buprestidae), and related species are deciduous tree pests. Female beetles prefer to oviposit at tree bases, and larvae tunnel beneath the bark, which weakens or kills young or newly transplanted trees. In the first objective of this study, Discus N/G (2.94% imidacloprid + 0.7% cyfluthrin) applied at six lower-than-labeled rates (0.0, 0.98, 1.97, 3.94, 5.91, and 7.87 ml/cm of average trunk dia.) was evaluated for protection of field-grown maples. A second objective evaluated imidacloprid with and without herbicides to assess the impact of weed competition at the tree base on insecticide effectiveness. A third objective determined relative imidacloprid concentrations in leaf tissue samples with ELISA and related to insecticide rates, herbicide treatments, and the level of flatheaded borer protection. In two trials, higher rates of insecticide were more effective at protecting trees, with rates ≥3.94 ml product/cm trunk diameter performing equivalently. Weed-free trees had more borer attacks and grew faster than trees in weedy plots. Imidacloprid content in leaf tissues had a trend for higher concentrations in smaller, weedy trees in the first season, but that pattern disappeared in subsequent years. Based on fewer attacks in weedy versus weed-free trees (60−90% reduction), it was concluded that weed presence can reduce borer attack success in nurseries independent of insecticide treatment, but tree growth was reduced by weed presence. In addition, Discus applied at rates >3.94 ml/cm did not confer added borer damage protection in weedy plots.

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“…Conversely, neonicotinoids are currently the most widely used agricultural insecticides [13]. These selective insecticides specifically bind to the α -subunit of nicotinic acetylcholine receptors (nAChR), which is common in all insects [14,15]. Due to their difficulty to penetrate the blood-brain barrier, they should exert low toxicity in vertebrates.…”

Section: Introductionmentioning

confidence: 99%

Molecular Basis for Endocrine Disruption by Pesticides Targeting Aromatase and Estrogen Receptor

Zhang

Schilirò²,

Gea³

et al. 2020

IJERPH

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The intensive use of pesticides has led to their increasing presence in water, soil, and agricultural products. Mounting evidence indicates that some pesticides may be endocrine disrupting chemicals (EDCs), being therefore harmful for the human health and the environment. In this study, three pesticides, glyphosate, thiacloprid, and imidacloprid, were tested for their ability to interfere with estrogen biosynthesis and/or signaling, to evaluate their potential action as EDCs. Among the tested compounds, only glyphosate inhibited aromatase activity (up to 30%) via a non-competitive inhibition or a mixed inhibition mechanism depending on the concentration applied. Then, the ability of the three pesticides to induce an estrogenic activity was tested in MELN cells. When compared to 17β-estradiol, thiacloprid and imidacloprid induced an estrogenic activity at the highest concentrations tested with a relative potency of 5.4 × 10−10 and 3.7 × 10−9, respectively. Molecular dynamics and docking simulations predicted the potential binding sites and the binding mode of the three pesticides on the structure of the two key targets, providing a rational for their mechanism as EDCs. The results demonstrate that the three pesticides are potential EDCs as glyphosate acts as an aromatase inhibitor, whereas imidacloprid and thiacloprid can interfere with estrogen induced signaling.

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Time-Cumulative Toxicity of Neonicotinoids: Experimental Evidence and Implications for Environmental Risk Assessments

Cited by 41 publications

References 95 publications

Similarities between pandemics and cancer in growth and risk models

Similarities between pandemics and cancer in growth and risk models

Evaluation of Systemic Imidacloprid and Herbicide Treatments on Flatheaded Borer (Coleoptera: Buprestidae) Management in Field Nursery Production

Molecular Basis for Endocrine Disruption by Pesticides Targeting Aromatase and Estrogen Receptor

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