Time Course to Resolution of Consumptive Hypothyroidism Associated with Infantile Hepatic Hemangioma Treated with Propranolol

Emerick, Jill E; Hack, Kara; Larson, Noelle; Jensen, Kirk; Bauer, Andrew J.

doi:10.1210/endo-meetings.2011.part3.or5.or24-5

TRANSLATIONAL - Iodine &Amp; Clinical Thyroid Disease 2011

DOI: 10.1210/endo-meetings.2011.part3.or5.or24-5

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Time Course to Resolution of Consumptive Hypothyroidism Associated with Infantile Hepatic Hemangioma Treated with Propranolol

Jill E Emerick¹,

Kara Hack²,

Noelle Larson³

et al.

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Consumptive Hypothyroidism: Case Report of Hepatic Hemangioendotheliomas Successfully Treated with Vincristine and Systematic Review of the Syndrome

et al. 2017

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Objectives: To provide a comprehensive description of consumptive hypothyroidism syndrome (CHS), a severe form of hypothyroidism that occurs due to the high expression levels of thyroid hormone inactivation enzyme type 3 deiodinase (D3) in tumors. Study Design: Case report and systematic review. Results: A 7-month-old girl with a diagnosis of massive hepatic hemangioendotheliomas was treated with high doses of thyroid hormones and tumor-directed chemotherapy with vincristine. The tumor displayed excellent response, and euthyroid status was regained. A systematic review on the databases PubMed/Medline and Embase was performed, using the term “Consumptive AND “Hypothyroidism.” From the 33 selected references, we extracted 42 case reports of CHS: 36 children and 6 adults. The laboratory profile at diagnosis displayed high TSH and low T₄ and T₃ serum levels. The serum reverse T₃ and D3 activity levels were high in all patients tested. In children, 97% had vascular tumors, whereas in adults 33% were vascular tumors, 33% fibrous tumors, and 33% gastrointestinal stromal tumors. The conservative treatment was predominant in children, while in adults all cases were treated with surgery. Death occurred in 16% of children and 33% of adults. Conclusions: CHS is a rare form of hypothyroidism that occurs in children and adults, usually linked to hepatic vascular tumors. The condition is associated with high lethality. Prompt diagnosis, followed by high-dose thyroid hormone replacement and tumor-directed therapy are the keys to optimize outcomes.

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Consumptive Hypothyroidism: Case Report of Hepatic Hemangioendotheliomas Successfully Treated with Vincristine and Systematic Review of the Syndrome

et al. 2017

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Time Course to Resolution of Consumptive Hypothyroidism Associated with Infantile Hepatic Hemangioma Treated with Propranolol

Cited by 1 publication

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Consumptive Hypothyroidism: Case Report of Hepatic Hemangioendotheliomas Successfully Treated with Vincristine and Systematic Review of the Syndrome

Consumptive Hypothyroidism: Case Report of Hepatic Hemangioendotheliomas Successfully Treated with Vincristine and Systematic Review of the Syndrome

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