Time course of the haemodynamic response to visual stimulation in migraine, measured using near-infrared spectroscopy

Coutts, Louise V.; Cooper, Chris E.; Elwell, Clare E.; Wilkins, Arnold J.

doi:10.1177/0333102412444474

Cited by 39 publications

(58 citation statements)

References 33 publications

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“…For example, Huang et al (2003) found that patients with migraine showed larger BOLD responses to grating stimuli than controls. It is therefore of interest that Coutts et al (2012) using NIRS found that patients with migraine showed shorter oxyhaemoglobin responses compared to healthy controls, suggesting that the shape of the haemodynamic response can also be related to cortical excitability. This suggestion is consistent with the findings of Muthukumaraswamy et al (2012) that individuals with lower concentrations of GABA produced taller and thinner BOLD responses in the visual cortex, compared to individuals with higher concentrations of GABA.…”

Section: Introductionmentioning

confidence: 99%

“…We manipulated stimulus parameters that have been shown to affect viewing comfort and to influence the probability of paroxysmal EEG activity in patients with photosensitive epilepsy. Following the findings reported by Muthukumaraswamy et al (2012) and Coutts et al (2012), we chose to focus on the effect of the stimulus parameters on the oxyhaemoglobin response during stimulus presentation and immediately after stimulus presentation, and the effect on the size of the post-stimulus undershoot (PSU). Our aim was to measure the haemodynamic response in relation to cortical excitation.…”

Section: Introductionmentioning

confidence: 99%

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Cortical excitability and the shape of the haemodynamic response

2015

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Individual differences in the temporal dynamics of the haemodynamic response can reflect cortical excitation and can reveal underlying cortical physiology. Here, we show differences in the shape of the haemodynamic response that are dependent on stimulus parameters. Two sets of visual stimuli were used varying in parameters that are known to manipulate the haemodynamic response in the visual cortex. We measured the oxyhaemoglobin response using near infrared spectroscopy. The first set of stimuli comprised chromatic square-wave gratings that varied with respect to the separation in the CIE UCS chromaticities of the alternating bars. The gratings with large separations in chromaticity evoked an oxyhaemoglobin response with greater amplitude, consistent with greater activation of the visual cortex. The second set of stimuli comprised horizontal achromatic gratings that (1) were static, (2) drifted at a constant velocity towards fixation, or (3) reversed direction every half spatial cycle to create a vertical vibrating motion. Although the three types of grating had a similar effect on the amplitude of the oxyhaemoglobin response, the moving gratings (2 and 3) evoked a steeper decrease in oxyhaemoglobin concentration after stimulus-offset. The steeper slope appears to reflect the poststimulus undershoot and the slope may provide a correlate of cortical excitability when the amplitude of the haemodynamic response has saturated.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cortical excitability and the shape of the haemodynamic response

2015

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“…When the discomfort is reduced by the use of tinted ophthalmic lenses, the cortical response is 'normalised'; that is, the migraineurs then show a similar cortical response to controls (Huang et al, 2011;Coutts et al, 2012). The experiments reported here suggest that the heightened cortical response to the uncomfortable patterns is not dependent on poor accommodation.…”

Section: Discussionmentioning

confidence: 59%

Accommodation to Uncomfortable Patterns

et al. 2013

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Grating patterns can cause discomfort and perceptual distortions. Individuals who experience discomfort and are susceptible to these distortions generally show weaker accommodation than those who are less susceptible. We measured the accommodative response to grating patterns known to differ in the discomfort they evoke because of differences in their colour, motion or spatial frequency. The parameters known to affect discomfort and distortion had no influence on the mean or variance in the accommodative response, even when accommodative demand was manipulated systematically and the accommodative response varied as expected.3

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“…We are also exploring novel ways of analyzing this data by looking at duration of sustained activation as opposed to maximum change [16], and are in the process of collecting data in an age-matched UK sample.…”

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confidence: 99%

Using fNIRS to Study Working Memory of Infants in Rural Africa

Begus

Lloyd‐Fox

Halliday

et al. 2016

Advances in Experimental Medicine and Biology

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A pilot study was conducted to assess the feasibility of using fNIRS as an alternative to behavioral assessments of cognitive development with infants in rural Africa. We report preliminary results of a study looking at working memory in 12-16-month-olds and discuss the benefits and shortcomings for the potential future use of fNIRS to investigate the effects of nutritional insults and interventions in global health studies.

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Time course of the haemodynamic response to visual stimulation in migraine, measured using near-infrared spectroscopy

Abstract: The time course of the functional response as measured by NIRS may be an effective tool to track therapy with PSF and explore the mechanisms of visual stress in migraine.

Cited by 39 publications

References 33 publications

Cortical excitability and the shape of the haemodynamic response

Cortical excitability and the shape of the haemodynamic response

Accommodation to Uncomfortable Patterns

Using fNIRS to Study Working Memory of Infants in Rural Africa

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