Time course of the bronchoconstriction induced by inhaled histamine and methacholine

Cartier, André; Malo, Jean‐Luc; Bégin, Paul; Sestier, Maude; Martin, Richard R.

doi:10.1152/jappl.1983.54.3.821

Cited by 103 publications

(48 citation statements)

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“…Furthermore, a randomized sequence would complicate the intricate procedure the young children had to perform during the repeated challenges. In a subgroup of children, the time-dependent weaning of bronchial obstruction revealed that airway obstruction stabilized within 87% of the initial degree of obstruction for at least 10 min after inhalation of methacholine, which is in accordance with previous reports [17,49]. Our measurements were performed within this time period and are, accordingly, unlikely to be severely affected by time-dependent changes.…”

Section: Discussionsupporting

confidence: 92%

Lung function measurement in awake young children

Bisgaard¹,

Klug²

1995

Eur Respir J

252

208

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Keywords: interrupter lung function oscillometry spirometry transcutaneous measurements of oxygen whole body plethysmography young children Received: December 14 1994 Accepted after revision August 28 1995 This study was supported by grants from the Danish Ministry of Health and from Astra-Draco, Lund, Sweden.Eur Respir J, 1995, 8, 2067-2075 DOI: 10.1183 ) were compared with concomitant measurements of specific airway resistance (sRaw) and forced expiratory volume in one second (FEV1) by whole body plethysmography and spirometry, respectively, during methacholine challenge in 21 young children aged 4-6 yrs, with suspected asthma. Measurements with each technique were repeated after each challenge step. A special face-mask was developed with an integrated mouthpiece which ensured mouth breathing during the measurements.The order of sensitivity of the techniques to assess methacholine-induced changes in lung function was ZIOS > sRaw > Ptc,O 2 > FEV1 > Rint. ZIOS was significantly more sensitive than all subsequent methods, and Ptc,O 2 was significantly more sensitive than FEV1. ZIOS, sRaw and Rint, but not Ptc,O 2 and FEV1, detected the subclinical increase in bronchial muscle tone in the children during baseline, which was revealed by the significantly reduced airway obstruction after inhalation of a b b b b b 2 -agonist as compared to baseline.It is concluded that ZIOS, Rint and Ptc,O 2 change in parallel with sRaw and FEV1 and with a comparable sensitivity during simultaneous measurements of the response to methacholine in young children aged 4-6 yrs. This implies that ZIOS, Rint and Ptc,O 2 provide convenient indices of changes in lung function. Their combined use will be useful for monitoring airway diseases of young children.

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Section: Discussionsupporting

confidence: 92%

Lung function measurement in awake young children

Bisgaard¹,

Klug²

1995

Eur Respir J

252

208

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“…Initially, whether administered by aerosol to the alveolar or bronchial regions of the lungs, histamine-induced bronchoconstriction appeared to follow a time course for peak response similar to those demonstrated by others (32), with a somewhat more rapid recovery. Although similar doses of predominantly bronchial and alveolar histamine resulted in similar magnitudes of the peak responses of R L and RR, the high bronchial histamine dose caused a greater and prolonged change in C dyn , P CO2 , and R L .…”

Section: Discussionsupporting

confidence: 68%

Bronchial, alveolar, and vascular-induced anaphylaxis and irritant-induced cardiovascular and pulmonary responses.

Yeates

Mussatto

Hameister

et al. 2001

Environ Health Perspect

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Inhaled irritants and allergens initiate a pulmonary chemoreflex that can result in responses both in the lung and heart as well as in the systemic and the peripheral vasculatures. These responses are due to both neural reflexes and the activation of humoral receptors by circulating mediators (1). Histamine, a major mediator released by IgE activation, participates in many of the immediate cardiopulmonary physiologic consequences of inhaled antigen in both humans (2) and dogs (3). Histamine is released from mast cells and basophils in the alveolar interstitium and in bronchial mucosa. The number of mast cells in the alveoli (350/mm 2 ) (4) markedly exceeds that in the bronchial mucosa, 226/mm 2 (5) when the relative surface areas of each are considered. Histamine can activate pulmonary C fibers (6), bronchial C fibers (7), and bronchial irritant fibers (6,8). The stimulation of select subsets of each of these fibers has been shown to increase bronchopulmonary smooth muscle tone (9) and elicit the pulmonary chemoreflex typified by rapid shallow breathing, bradycardia, and hypotension. Histamine (10) and inhaled allergens (11) stimulate mucociliary transport. As the functions of the respiratory central pattern generator, bronchial and vascular smooth muscle, and the mucosa are quite distinct, the relative responses of and pathways through which each of these responds to histamine and allergens must each be evaluated.To determine the relative cardiovascular, respiratory, and epithelial responses elicited by histamine administered to the alveolar, bronchial, and vascular compartments and the role of neural pathways in mediating these events, we conducted a series of experiments in beagle dogs. In addition we evaluated cardiovascular, respiratory, and epithelial responses elicited by ragweed allergen administered to the alveolar and bronchial compartments in a cohort of ragweed-sensitized dogs and nonsensitized siblings. Activation of the pulmonary chemoreflex was demonstrated by the measurements of respiratory rate, heart rate, and arterial blood pressure. Efferent responses of the mucosa were assayed in terms of mucociliary clearance, whereas responses of smooth muscles were indicated by either pulmonary resistance or transpulmonary pressure and compliance. Indication of histamine or allergen-induced impairment of gas exchange was determined from the measurement of minute ventilation and arterial blood gases. In these experiments, equivalent total masses of histamine (approximately 185 µg) deposited in the lungs were partitioned such that in one set of experiments 71% was deposited in the bronchi; in the other set 91% was deposited in the alveoli. Responses from the predominantly alveolar deposition due to the 9% deposited in the bronchi were assessed separately by depositing 16 µg in the bronchi. The contribution of vagal transmission was ascertained following bilateral sectioning of the vagosympathetic trunks. To evaluate the extent to which histamine-induced responses due to its translocation from the airways to...

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“…Denoting these as N 0 and then substituting ⌬f ϭ N 0 /t pulse into Eq. [5] gives the slice gradient strength…”

Section: The 3 He Diffusion Attenuation Problemmentioning

confidence: 99%

“…Third, the image should be acquired sufficiently rapidly to capture the response before the airways relax back to their open state. These issues are all exacerbated in small animal MRI, where airway relaxation to baseline is likely to be faster than in humans (5) and voxels must be ϳ3000 times smaller. High spatial resolution is typically achieved in small animals by acquiring images over multiple breaths (6,7).…”

mentioning

confidence: 99%

³He MRI in mouse models of asthma

Driehuys

Walker

Pollaro

et al. 2007

Magnetic Resonance in Med

114

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In the study of asthma, a vital role is played by mouse models, because knockout or transgenic methods can be used to alter disease pathways and identify therapeutic targets that affect lung function. Assessment of lung function in rodents by available methods is insensitive because these techniques lack regional specificity. A more sensitive method for evaluating lung function in human asthma patients uses hyperpolarized (HP) 3 He MRI before and after bronchoconstriction induced by methacholine (MCh). We now report the ability to perform such 3 He imaging of MCh response in mice, where voxels must be ϳ3000 times smaller than in humans and 3 He diffusion becomes an impediment to resolving the airways. We show three-dimensional (

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Time course of the bronchoconstriction induced by inhaled histamine and methacholine

Cited by 103 publications

References 0 publications

Lung function measurement in awake young children

Lung function measurement in awake young children

Bronchial, alveolar, and vascular-induced anaphylaxis and irritant-induced cardiovascular and pulmonary responses.

³He MRI in mouse models of asthma

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Time course of the bronchoconstriction induced by inhaled histamine and methacholine

Cited by 103 publications

References 0 publications

Lung function measurement in awake young children

Lung function measurement in awake young children

Bronchial, alveolar, and vascular-induced anaphylaxis and irritant-induced cardiovascular and pulmonary responses.

3He MRI in mouse models of asthma

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³He MRI in mouse models of asthma