Time course of systemic oxidative stress and inflammatory response induced by an acute exposure to Residual Oil Fly Ash

Marchini, Timoteo; Magnani, Natalia; Paz, Mariela L.; Vanasco, Virginia; Tasat, Deborah Ruth; Maglio, Daniel Horacio González; Álvarez, Silvia; Evelson, Pablo

doi:10.1016/j.taap.2013.11.013

Cited by 54 publications

(39 citation statements)

References 54 publications

(80 reference statements)

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“…Particles were administered by intranasal instillation to the anesthetized animal, which is a useful and well-accepted model of exposure to PM (Southam et al, 2002). In experimental models similar to ours, which used ROFA instilled intranasally in mice, doses amounting to 25 times (Biselli et al, 2011; Magnani et al, 2013; Marchini et al, 2014) and up to 60 times greater (Arantes-Costa et al, 2008) than ours were used.…”

Section: Discussionmentioning

confidence: 76%

“…ROFA is a suspension of the material produced after oil burning, which was used in some experimental models of exposure to air pollution (Ghio et al, 2002; Arantes-Costa et al, 2008; Avila et al, 2011; Marchini et al, 2014). Although ROFA exposure does not exactly mimic the overall environmental pollution, this PM contains high concentrations of many components of air pollution.…”

Section: Discussionmentioning

confidence: 99%

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Time course of pulmonary burden in mice exposed to residual oil fly ash

et al. 2014

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Residual oil fly ash (ROFA) is a common pollutant in areas where oil is burned. This particulate matter (PM) with a broad distribution of particle diameters can be inhaled by human beings and putatively damage their respiratory system. Although some studies deal with cultured cells, animals, and even epidemiological issues, so far a comprehensive analysis of respiratory outcomes as a function of the time elapsed after exposure to a low dose of ROFA is wanted. Thus, we aimed to investigate the time course of mechanical, histological, and inflammatory lung changes, as well as neutrophils in the blood, in mice exposed to ROFA until 5 days after exposure. BALB/c mice (25 ± 5 g) were randomly divided into 7 groups and intranasally instilled with either 10 μL of sterile saline solution (0.9% NaCl, CTRL) or ROFA (0.2 μg in 10 μL of saline solution). Pulmonary mechanics, histology (normal and collapsed alveoli, mononuclear and polymorphonuclear cells, and ultrastructure), neutrophils (in blood and bronchoalveolar lavage fluid) were determined at 6 h in CTRL and at 6, 24, 48, 72, 96, and 120 h after ROFA exposure. ROFA contained metal elements, especially iron, polycyclic aromatic hydrocarbons (PAHs), and organochlorines. Lung resistive pressure augmented early (6 h) in the course of lung injury and other mechanical, histological and inflammatory parameters increased at 24 h, returning to control values at 120 h. Blood neutrophilia was present only at 24 and 48 h after exposure. Swelling of endothelial cells with adherent neutrophils was detected after ROFA instillation. No neutrophils were present in the lavage fluid. In conclusion, the exposure to ROFA, even in low doses, induced early changes in pulmonary mechanics, lung histology and accumulation of neutrophils in blood of mice that lasted for 4 days and disappeared spontaneously.

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Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Time course of pulmonary burden in mice exposed to residual oil fly ash

et al. 2014

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“…Systemic oxidative stress and brisk inflammatory responses are seen in animal models and in humans exposed to polluted environments with diverse PM chemistry, including residual oil flash, endotoxins, and metals as well as high concentrations of criteria pollutants [40][41][42]. The individual inflammatory responses to air pollutants depend of diverse factors, including mitochondrial genetic background, age, gender, and chronic diseases [43,44].…”

Section: Neuroinflammatory and Neurodegenerative Changesmentioning

confidence: 99%

Air pollution, a rising environmental risk factor for cognition, neuroinflammation and neurodegeneration: The clinical impact on children and beyond

et al. 2016

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Air pollution (indoor and outdoor air) is a major issue in public health as epidemiological studies haven pointed to the numerous detrimental health consequences (notably, respiratory and cardiovascular pathology). In the last fifteen years, air pollution has also been considered as a potent environmental risk factor for neurological diseases and neuropathology. In this review, the authors examine the impact of air pollution on children's brain development and its clinical, cognitive, brain structural and metabolic consequences. Long-term potential consequences for adults' brain and effects on multiple sclerosis are also discussed. One challenge is assessing lifetime exposures to outdoor and indoor environments, including occupational exposures: how much, for how long and what type. The diffuse neuroinflammation, the damage to the neurovascular unit, and the production of auto-antibodies to neural and tight junction proteins are worrisome findings in children chronically exposed to concentrations above current standards for ozone and fine particulate matter (PM 2.5 ) and may constitute significant risk factors for the development of Article Outline

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“…In the present study, positive action of CrPic was not observed, likely because there was no depletion of antioxidant enzymes or increased oxidative stress in our sample. Other studies investigating the effects of antioxidant supplementation have reported that supplementation has led to beneficial effects and reduced oxidative stress only in individuals with low baseline antioxidant profiles [43,51,54,55].…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, acute inhalation of concentrated ambient particles and ROFA has been found to lead to potential oxidant injuries, followed by an up-regulation of antioxidant defenses. After a 24 h inhalation period, reversibility of oxidative stress occurs, suggesting that oxidants mediated by pollution exposure may trigger adaptive responses in the lungs and heart [40][41][42][43]. Moreover, our study was performed using healthy animals.…”

Section: Discussionmentioning

confidence: 99%

Aerobic training reduces oxidative stress in skeletal muscle of rats exposed to air pollution and supplemented with chromium picolinate

et al. 2018

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(2018) Aerobic training reduces oxidative stress in skeletal muscle of rats exposed to air pollution and supplemented with chromium picolinate, Redox Report, 23:1, 146-152, DOI: 10.1080/13510002.2018 Objective: The purpose of this study was to investigate the effects of chromium picolinate (CrPic) supplementation associated with aerobic exercise using measures of oxidative stress in rats exposed to air pollution. Methods: Sixty-one male Wistar rats were divided into eight groups: residual oil fly ash (ROFA) exposure and sedentary (ROFA-SED); ROFA exposure, sedentary and supplemented (ROFA-SEDCrPic); ROFA exposure and trained (ROFA-AT); ROFA exposure, supplemented and trained (ROFA-AT-CrPic); sedentary (Sal-SED); sedentary and supplemented (Sal-SED-CrPic); trained (Sal-AT); and supplemented and trained (Sal-AT-CrPic). Rats exposed to ROFA (air pollution) received 50 μg of ROFA daily via intranasal instillation. Supplemented rats received CrPic (1 mg/kg/day) daily by oral gavage. Exercise training was performed on a rat treadmill (5×/week). Oxidative parameters were evaluated at the end of protocols. Results: Trained groups demonstrated lower gain of body mass (P < .001) and increased exercise tolerance (P < .0001). In the gastrocnemius, trained groups demonstrated increased SOD activity (P < .0001) and decrease levels of TBARS (P = .0014), although CAT activity did not differ among groups (P = .4487). Conclusion: Air pollution exposure did not lead to alterations in oxidative markers in lungs and heart, and exercise training was responsible for decreasing oxidative stress of the gastrocnemius.

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Time course of systemic oxidative stress and inflammatory response induced by an acute exposure to Residual Oil Fly Ash

Cited by 54 publications

References 54 publications

Time course of pulmonary burden in mice exposed to residual oil fly ash

Time course of pulmonary burden in mice exposed to residual oil fly ash

Air pollution, a rising environmental risk factor for cognition, neuroinflammation and neurodegeneration: The clinical impact on children and beyond

Aerobic training reduces oxidative stress in skeletal muscle of rats exposed to air pollution and supplemented with chromium picolinate

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