Time Course of Spirapril-Induced Structural and Functional Changes After Myocardial Infarction in Rats Followed with Magnetic Resonance Imaging

Zierhut, Wolfgang; Rudin, Markus; Robertson, Evelyn F.; Hg, Zerwes; Novosel, Dragutin; Jp, Evenou; Stirnimann, Roger; Rp, Hof

doi:10.1097/00005344-199306000-00014

Cited by 13 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the literature, there are little serial data about hypertrophic changes in rats after MI. Zierhut et al (15) used a non‐cine spin‐echo technique to follow hypertrophy and found a slight but insignificant increase of myocardial mass and no changes in end‐diastolic wall thickness from six to 13 weeks post‐MI. In this study, only one diastolic image per heart cycle was obtained.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, the exact underlying mechanisms and the precise time course of LV remodeling are still not fully understood. The noninvasive and exact nature of MRI make it a valuable tool for cardiac studies (9–16). Cine‐fast low‐angle shot (FLASH)‐MRI has been shown to provide good spatial and temporal resolution for the validation of an infarction model of the rat heart (17).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Serial cine‐magnetic resonance imaging of left ventricular remodeling after myocardial infarction in rats

Nahrendorf

Wiesmann

Hiller

et al. 2001

Magnetic Resonance Imaging

View full text Add to dashboard Cite

The purpose of the present study was the serial investigation of morphological and functional changes after left coronary artery ligation in the intact rat using cine-magnetic resonance imaging (MRI). MRI studies were performed 4, 8, 12, and 16 weeks after myocardial infarction (MI) with an echocardiogram (ECG)-triggered cine-fast lowangle shot (FLASH)-sequence in a 7-Tesla magnet. MI-size, left ventricular (LV) mass and volumes, cardiac index, ejection fraction (EF), and remote wall and scar thickness of 11 Wistar rats were compared to four sham-operated rats. Stress MRI with dobutamine (10 l/kg ؋ minute) was performed at 16 weeks. In MI groups (small MI < 30%, N ‫؍‬ 5, large MI > 30%, N ‫؍‬ 6), there was significant increase of LV mass (small MI ؉ 47.8% increase, large MI ؉ 74.1%) and wall thickness (large MI 1.21 ؎ 0.03 to 1.84 ؎ 0.07 mm). Scar thickness declined from four to 16 weeks (large MI 0.92 ؎ 0.06 to 0.38 ؎ 0.02mm, P < 0.05). End-diastolic volume of both MI groups was significantly elevated but increased further only in animals with large MI from four to 16 weeks (657.1 ؎ 38.6 to 869.7 ؎ 60.7 L, P < 0.05). Compared to sham, EF was significantly depressed in MI (large MI 31.5 ؎ 2.0%). Wall thickening declined from four to 16 weeks post-MI (large MI 50.9 ؎ 9.9 to 28.9 ؎ 4.4%, P < 0.05). During stress, sham and MI rats increased wall thickening from 66.5 ؎ 8.2 to 111.2 ؎ 6.7% and from 30.8 ؎ 4.3 to 47.5 ؎ 5.8%, respectively (P < 0.05). Hypertrophy was found in all animals with MI throughout the entire period of observation, whereas dilatation after four weeks was only detected in animals with large MI. These Index terms: MRI; heart; myocardial infarction; rat; remodeling CORONARY ARTERY DISEASE with subsequent myocardial infarction (MI) is the most frequent cause for the development of chronic heart failure (1). The morphological and functional features of left ventricular (LV) remodeling have been studied both in animal models (2,3) and in humans (4 -6). The rat model of MI with consecutive LV dilatation has proved to be particularly valuable for the investigation of the development of heart failure and its prevention (7,8). However, the progressive, complex changes of LV geometry of the model have yet to be followed by exact sequential magnetic resonance imaging (MRI) measurements. In addition, the initial size of the MI is unknown in studies that rely on post-mortem measurements, due to MI expansion and remodeling of surviving myocardium. Thus, the exact underlying mechanisms and the precise time course of LV remodeling are still not fully understood. The noninvasive and exact nature of MRI make it a valuable tool for cardiac studies (9 -16). Cine-fast lowangle shot (FLASH)-MRI has been shown to provide good spatial and temporal resolution for the validation of an infarction model of the rat heart (17). This study aimed to better understand the remodeling process following MI by evaluating LV mass, wall thickness, volumes, and function over a specified time course. METHODS Experimental ProtocolSixtee...

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Serial cine‐magnetic resonance imaging of left ventricular remodeling after myocardial infarction in rats

Nahrendorf

Wiesmann

Hiller

et al. 2001

Magnetic Resonance Imaging

View full text Add to dashboard Cite

show abstract

“…8 Infarct sizes were calculated as the percentage of ventricle that was markedly thinned and hypokinetic. 9 Ultimately, the MI groups were culled on the basis of MRI analysis of infarct size to eliminate rats with small infarcts and to balance the infarct size between the 2 MI cohorts.…”

Section: Measurement Of Infarct Size By Mrimentioning

confidence: 99%

Effects of Early Angiotensin-Converting Enzyme Inhibition on Cardiac Gene Expression After Acute Myocardial Infarction

Jin¹,

Yang²,

Awad³

et al. 2001

Circulation

View full text Add to dashboard Cite

show abstract

“…Quantitative analysis of MR infarct size and myocardial mass and function was performed by a method described by Zierhut et al 19 Briefly, infarct size was expressed as the ratio of scar length to total circumference determined by manual delineation of epicardial and endocardial borders of scar length and total circumference of each cine image. Histological studies have reported that the summation of these length measurements approximates the surface of the infarcted area.…”

Section: Infarct Size Myocardial Function and Myocardial Massmentioning

confidence: 99%

Serial Magnetic Resonance Imaging of Microvascular Remodeling in the Infarcted Rat Heart

et al. 2001

View full text Add to dashboard Cite

show abstract

Time Course of Spirapril-Induced Structural and Functional Changes After Myocardial Infarction in Rats Followed with Magnetic Resonance Imaging

Cited by 13 publications

References 0 publications

Serial cine‐magnetic resonance imaging of left ventricular remodeling after myocardial infarction in rats

Serial cine‐magnetic resonance imaging of left ventricular remodeling after myocardial infarction in rats

Effects of Early Angiotensin-Converting Enzyme Inhibition on Cardiac Gene Expression After Acute Myocardial Infarction

Serial Magnetic Resonance Imaging of Microvascular Remodeling in the Infarcted Rat Heart

Contact Info

Product

Resources

About