Time course of neuroprotection induced by normobaric hyperoxia and NCX1 expression

Mohammadi, Ekram; Bigdeli, Mohammad Reza

doi:10.3109/02699052.2014.896472

Cited by 4 publications

(2 citation statements)

References 23 publications

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“…NCX activation reduces the brain infarct volume extension after permanent middle cerebral artery occlusion (MCAO), and the selective pharmacological blockade of NCX worsen the brain lesion, suggesting a protective role played by the exchanger during the events leading to brain ischemia (Pignataro et al, 2004). NCX3 unlike the other NCXs family members (NCX1and NCX2), has a peculiar capability to maintain [Ca 2+ ]i homeostasis even when ATP levels are reduced considerably; therefore, it has a major role in neuronal preservation during hypoxic conditions (Mohammadi & Bigdeli, 2014;Secondo et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

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Protective Effect of the Viola spathulata Extract on NCX3 Gene Expression in an Animal Model of Cerebral Ischemia

Abedinzade¹,

Mohammadi²,

Hedayati³

et al. 2022

BCN

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Introduction: Viola plant has been used traditionally for the treatment of neurological disorders. We aimed at determining whether pretreatment with Viola spathulata extract can alleviate the severity of ischemic-reperfusion damages and it can exert its protective effects through the regulation of a sodium/calcium exchanger (NCX3) gene expression in a rat brain. Methods: Male Wistar rats were divided into two main groups, including one main group for evaluating neurologic deficit score (NDS) and infarct volume (IV) and the other group for the evaluation of NCX3 gene expression in the brain tissue, which were subdivided to the intact, control (vehicle), sham, V5, and V10 subgroups. The vehicle (control) sub-group received DMSO and V5 and V10 sub-group received V.spathulata extract at the doses of 5 and 10 mg/kg, respectively for 7 days (i.p.). After pretreatment, a 60-min middle cerebral artery occlusion (MCAO) was carried out. Results: in the V5 and V10 groups, NDS and IV significantly decreased. MCAO up-regulated NCX3 gene expression in the core, penumbra, and subcortex regions compared with the intact subgroup. The V5 subgroup significantly down-regulated the NCX3 gene expression level in the core compared with the control subgroup. The V10 subgroup showed down-regulation of the NCX3 gene expression level in core, penumbra, and subcortex compared with the control subgroup. Conclusion: V.spathulata extract seems to have a neuroprotective role against MCAO- induced ischemic brain damage, possibly through preventing the alteration of NCX3 gene expression level.

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Section: Introductionmentioning

confidence: 99%

“…NCX3 , unlike the other NCXs family members (NCX1 and NCX2), has a peculiar capability to maintain [Ca 2+ ]i homeostasis even when ATP levels are reduced considerably. Therefore, it has a major role in neuronal preservation during hypoxic conditions ( Mohammadi & Bigdeli, 2014 ; Secondo et al, 2007 ).…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of the Viola spathulata Extract on NCX3 Gene Expression in an Animal Model of Cerebral Ischemia

Abedinzade¹,

Mohammadi²,

Hedayati³

et al. 2022

BCN

Self Cite

View full text Add to dashboard Cite

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Normobaric hyperoxia therapy in acute ischemic stroke: A literature review

Wang,

Zhang,

Suo

et al. 2024

Heliyon

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The effect of normobaric oxygen in patients with acute stroke: a systematic review and meta-analysis

Ding

Zhou

Meng

et al. 2018

Neurological Research

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Background Normobaric oxygen (NBO) has received considerable attention due to controversial data in brain protection in patients with acute stroke. This study aims to analyze current data of NBO on brain protection as used in the clinic. Methods We searched for and reviewed relevant articles and references from Pubmed, Medline, Embase, Cochrane, and Clincialtrials.gov that were published prior to October 2017. Data from prospective studies were processed using RevMan5.0 software, provided by Cochrane collaboration and transformed using relevant formulas. Results A total of 11 prospective RCT studies including 6366 patients with acute stroke (NBO group, 3207; control group, 3159) were enrolled in this analysis. △NIHSS represented the values of NIHSS at 4, 24 h, or 7 days post-stroke minus baseline NIHSS. Compared to controls, there was a minor trend toward NBO benefits in short-term prognostic indices, as indicated by decreased ΔNIHSS at our defined time points. By contrast, NBO decreased Barthel Index scores between 3 and 7 months, and increased death rates at 3, 6 months, and 1 year, whereas, modified Rankin Scale scores between 3 and 6 months were unchanged. Conclusions The existing trends toward benefits revealed in this meta-analysis help us appreciate the promising value of NBO, although current evidence of NBO on improving clinical outcomes of stroke is insufficient. Well-designed multi-center clinical trials are encouraged and urgently needed to further explore the efficacy of NBO on brain protection.

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Time course of neuroprotection induced by normobaric hyperoxia and NCX1 expression

Abstract: Although further studies are needed to clarify the mechanisms of time course of neuroprotection, HO partly is associated with expression of NCX1 consistent with an active role in the genesis of ischaemic neuroprotection.

Cited by 4 publications

References 23 publications

Protective Effect of the Viola spathulata Extract on NCX3 Gene Expression in an Animal Model of Cerebral Ischemia

Protective Effect of the Viola spathulata Extract on NCX3 Gene Expression in an Animal Model of Cerebral Ischemia

Normobaric hyperoxia therapy in acute ischemic stroke: A literature review

The effect of normobaric oxygen in patients with acute stroke: a systematic review and meta-analysis

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