Time Course of MERS-CoV Infection and Immunity in Dromedary Camels

Meyer, Benjamin; Juhász, Judit; Barua, Rajib; Gupta, Aungshuman Das; Hakimuddin, Fatima; Corman, Victor M.; Müller, Marcel A.; Wernery, Ulrich; Drosten, Christian; Nagy, Peter D.

doi:10.3201/eid2212.160382

Cited by 38 publications

(61 citation statements)

References 15 publications

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“…We found 10 longitudinal studies describing 9 incidences of natural infection on farms and in quarantine facilities -1 in Egypt (Ali et al, 2017b), 4 in KSA (Azhar et al, 2014;Hemida et al, 2014a;Memish et al, 2014;Hemida et al, 2017a), 5 in UAE (Al Hammadi et al, 2015;Wernery et al, 2015a;Meyer et al, 2016;Muhairi et al, 2016;Yusof et al, 2017) and 1 study taking monthly samples of 430 dromedaries in Kenya (Kiambi et al, 2018).…”

Section: Evidence Of Infection and Immunity From Longitudinal Studiesmentioning

confidence: 99%

“…Three studies have found dromedaries to be shedding MERS-CoV RNA despite having high antibody titres months or weeks prior to detectable infection. Both older animals whose antibodies reflect past exposure (Meyer et al, 2016;Ali et al, 2017b;Hemida et al, 2017a), and young calves whose high antibody titres were maternally-acquired immediately post-partum, became infected (Meyer et al, 2016).…”

Section: Evidence Of Reinfectionmentioning

confidence: 99%

“…Dighe, et al Epidemics 29 (2019) 100350 Longitudinal studies also indicated that maternally acquired immunity may offer some protection. In both studies of calf-mother-pairs conducted in UAE, MERS-CoV infection became highly prevalent in calves between 4-6 months of age when maternally-acquired antibody titres had waned (Wernery et al, 2015a;Meyer et al, 2016). Samples from reinfected animals have been found to have lower viral loads, suggesting that past infection may ameliorate future infections (Hemida et al, 2017a).…”

Section: Evidence Of Reinfectionmentioning

confidence: 99%

“…Samples from reinfected animals have been found to have lower viral loads, suggesting that past infection may ameliorate future infections (Hemida et al, 2017a). Viral load and probability of isolating infectious virus were greater when sampling calves, than adults (Meyer et al, 2016;Ommeh et al, 2018).…”

Section: Evidence Of Reinfectionmentioning

confidence: 99%

See 3 more Smart Citations

A systematic review of MERS-CoV seroprevalence and RNA prevalence in dromedary camels: Implications for animal vaccination

et al. 2019

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Syndrome Coronavirus (MERS-CoV) is driven by recurring dromedary-to-human spill-over events, leading decision-makers to consider dromedary vaccination. Dromedary vaccine candidates in the development pipeline are showing hopeful results, but gaps in our understanding of the epidemiology of MERS-CoV in dromedaries must be addressed to design and evaluate potential vaccination strategies. We aim to bring together existing measures of MERS-CoV infection in dromedary camels to assess the distribution of infection, highlighting knowledge gaps and implications for animal vaccination. We systematically reviewed the published literature on MEDLINE, EMBASE and Web of Science that reported seroprevalence and/or prevalence of active MERS-CoV infection in dromedary camels from both cross-sectional and longitudinal studies. 60 studies met our eligibility criteria. Qualitative syntheses determined that MERS-CoV seroprevalence increased with age up to 80-100% in adult dromedaries supporting geographically widespread endemicity of MERS-CoV in dromedaries in both the Arabian Peninsula and countries exporting dromedaries from Africa. The high prevalence of active infection measured in juveniles and at sites where dromedary populations mix should guide further investigation -particularly of dromedary movement -and inform vaccination strategy design and evaluation through mathematical modelling.

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Section: Evidence Of Infection and Immunity From Longitudinal Studiesmentioning

confidence: 99%

Section: Evidence Of Reinfectionmentioning

confidence: 99%

Section: Evidence Of Reinfectionmentioning

confidence: 99%

Section: Evidence Of Reinfectionmentioning

confidence: 99%

See 2 more Smart Citations

A systematic review of MERS-CoV seroprevalence and RNA prevalence in dromedary camels: Implications for animal vaccination

et al. 2019

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“…Experimental challenge and transmission studies provided key data regarding the time course of infection. Field studies have also provided valuable information, including evidence supporting the duration of pathogen shedding (Al Muhairi et al, ), and documenting transmission among dromedaries (Ali, Shehata, et al, ; Meyer et al, ).…”

Section: Discussionmentioning

confidence: 99%

A rapid scoping review of Middle East respiratory syndrome coronavirus in animal hosts

Gardner

Kelton

Poljak

et al. 2018

Zoonoses and Public Health

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Middle East respiratory syndrome coronavirus (MERS‐CoV) is an emerging zoonotic pathogen discovered in 2012. The purpose of this scoping review was to summarize the empirical evidence for MERS‐CoV in animals in order to map knowledge gaps and to extract data for modelling disease transmission in dromedary camels. A review protocol was developed a priori, and a systematic search, data extraction and summary were conducted using the Arksey and O'Malley framework. Ninety‐nine publications were identified for full review out of 1,368 unique records. Of these publications, 71 were articles in scientific journals. Ninety of the studies were observational and the remaining nine were experimental. We summarize characteristics of animal studies including study design, study population and outcomes of interest for future transmission modelling in the reservoir population. The majority of field studies reported measures of prevalence, while experimental studies provided estimates of transmission parameters that pertain to the natural course of disease.

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Sero‐prevalence of Middle East respiratory syndrome coronavirus (MERS‐CoV) specific antibodies in dromedary camels in Tabuk, Saudi Arabia

Harrath

Duhier

2018

Journal of Medical Virology

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The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is a novel Coronavirus which was responsible of the first case of human acute respiratory syndrome in the Kingdom of Saudi Arabia (KSA), 2012. Dromedary camels are considered as potential reservoirs for the virus and seem to be the only animal host which may transmit the infection to human. Further studies are required to better understand the animal sources of zoonotic transmission route and the risks of this infection. A primary sero-prevalence study of MERS-CoV preexisting neutralizing antibodies in Dromedary camel serum was conducted in Tabuk, western north region of KSA, in order to assess the seopositivity of these animals and to explain their possible role in the transmission of the infection to Human. One hundred seventy one (171) serum samples were collected from healthy dromedary camels with different ages and genders in Tabuk city and tested for specific serum IgG by ELISA using the receptor-binding S1 subunits of spike proteins of MERS-CoV. 144 (84,21%) of the total camel sera shown the presence of protein-specific antibodies against MERS-CoV. These results may provide evidence that MERS-CoV has previously infected dromedary camels in Tabuk and may support the possible role of camels in the human infection.

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Time Course of MERS-CoV Infection and Immunity in Dromedary Camels

Cited by 38 publications

References 15 publications

A systematic review of MERS-CoV seroprevalence and RNA prevalence in dromedary camels: Implications for animal vaccination

A systematic review of MERS-CoV seroprevalence and RNA prevalence in dromedary camels: Implications for animal vaccination

A rapid scoping review of Middle East respiratory syndrome coronavirus in animal hosts

Sero‐prevalence of Middle East respiratory syndrome coronavirus (MERS‐CoV) specific antibodies in dromedary camels in Tabuk, Saudi Arabia

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