Time course of lesion-induced atrophy in multiple sclerosis

Carolus, Keith; Fuchs, Tom; Bergsland, Niels; Ramasamy, Deepa P.; Tran, Hoan; Uher, Tomáš; Horáková, Dana; Vaněčková, Manuela; Havrdová, Eva; Benedict, Ralph H. B.; Zivadinov, Robert; Dwyer, Michael G.

doi:10.1007/s00415-022-11094-y

Cited by 3 publications

(2 citation statements)

References 51 publications

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“…Correlations between WM damage and connected DGM volumes have been shown in earlier studies, although these studies focused only on lesion volume and not on overall integrity of the entire tract [ 9 , 60 ]. Studies that did look at overall integrity of the tract at baseline and its effect on atrophy focused mainly on the thalamus [ 7 , 61 , 62 ]. Interestingly, a cross-sectional study showed that connectivity of thalamocortical tracts related to cortical, but not thalamic, atrophy [ 63 ], which may be in line with our results where we did not find any relations between WM and DGM atrophy, but only with CGM atrophy.…”

Section: Discussionmentioning

confidence: 99%

Multimodal MRI study on the relation between WM integrity and connected GM atrophy and its effect on disability in early multiple sclerosis

Weeda,

van Nederpelt,

Twisk

et al. 2023

J Neurol

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Background Multiple sclerosis (MS) is characterized by pathology in white matter (WM) and atrophy of grey matter (GM), but it remains unclear how these processes are related, or how they influence clinical progression. Objective To study the spatial and temporal relationship between GM atrophy and damage in connected WM in relapsing–remitting (RR) MS in relation to clinical progression. Methods Healthy control (HC) and early RRMS subjects visited our center twice with a 1-year interval for MRI and clinical examinations, including the Expanded Disability Status Scale (EDSS) and Multiple Sclerosis Functional Composite (MSFC) scores. RRMS subjects were categorized as MSFC decliners or non-decliners based on ΔMSFC over time. Ten deep (D)GM and 62 cortical (C) GM structures were segmented and probabilistic tractography was performed to identify the connected WM. WM integrity was determined per tract with, amongst others, fractional anisotropy (FA), mean diffusivity (MD), neurite density index (NDI), and myelin water fraction (MWF). Linear mixed models (LMMs) were used to investigate GM and WM differences between HC and RRMS, and between MSFC decliners and non-decliners. LMM was also used to test associations between baseline WM z-scores and changes in connected GM z-scores, and between baseline GM z-scores and changes in connected WM z-scores, in HC/RRMS subjects and in MSFC decliners/non-decliners. Results We included 13 HCs and 31 RRMS subjects with an average disease duration of 3.5 years and a median EDSS of 3.0. Fifteen RRMS subjects showed declining MSFC scores over time, and they showed higher atrophy rates and greater WM integrity loss compared to non-decliners. Lower baseline WM integrity was associated with increased CGM atrophy over time in RRMS, but not in HC subjects. This effect was only seen in MSFC decliners, especially when an extended WM z-score was used, which included FA, MD, NDI and MWF. Baseline GM measures were not significantly related to WM integrity changes over time in any of the groups. Discussion Lower baseline WM integrity was related to more cortical atrophy in RRMS subjects that showed clinical progression over a 1-year follow-up, while baseline GM did not affect WM integrity changes over time. WM damage, therefore, seems to drive atrophy more than conversely.

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Section: Discussionmentioning

confidence: 99%

Multimodal MRI study on the relation between WM integrity and connected GM atrophy and its effect on disability in early multiple sclerosis

Weeda,

van Nederpelt,

Twisk

et al. 2023

J Neurol

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“…Additionally, several studies have suggested that atrophy of the corpus callosum can also be a strategic biomarker to monitor MS-related neurodegeneration 6 . Recent studies have suggested that the disruption of white matter (WM) tracts impacts volume loss in connected deep GM over 5 years in patients with MS (pwMS) 7 . However, it has not been elucidated whether atrophy of both the GM and WM tracts at an early disease stage can predict future brain atrophy.…”

Section: Introductionmentioning

confidence: 99%

Early-stage volume losses in the corpus callosum and thalamus predict the progression of brain atrophy in patients with multiple sclerosis

Fujimori

Nakashima

2023

Preprint

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A method that can be used in the early stage of multiple sclerosis (MS) to predict the progression of brain volume loss (BVL) has not been fully established. Thus, to develop a method of predicting progressive BVL in patients with MS (pwMS), eighty-two consecutive Japanese pwMS—with either relapsing-remitting MS (86%) or secondary progressive MS (14%)—and 41 healthy controls were included in this longitudinal retrospective analysisover anobservational periodof approximately 3.5 years. Using a hierarchical cluster analysis with multivariate imaging data obtained by FreeSurfer analysis, we classified the pwMS into clusters. As a result, at baseline and follow-up, pwMS were cross-sectionally classified into three major clusters (Clusters 1, 2, and 3) in ascending order by disability and BVL. Among the patients included in Cluster 1 at baseline, approximately one-third of patients (12/52) transitioned into Cluster 2 at follow-up. The volumes of thecorpus callosum, the thalamus, and the whole brain excluding the ventricles were significantly decreased in the transition group compared with the nontransition group and were found to be the most important predictors of transition. Decreased volumes of thecorpus callosum and thalamus in the relatively early stage of MS may predict the development of BVL.

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Early-stage volume losses in the corpus callosum and thalamus predict the progression of brain atrophy in patients with multiple sclerosis

Fujimori,

Nakashima

2024

Journal of Neuroimmunology

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Time course of lesion-induced atrophy in multiple sclerosis

Cited by 3 publications

References 51 publications

Multimodal MRI study on the relation between WM integrity and connected GM atrophy and its effect on disability in early multiple sclerosis

Multimodal MRI study on the relation between WM integrity and connected GM atrophy and its effect on disability in early multiple sclerosis

Early-stage volume losses in the corpus callosum and thalamus predict the progression of brain atrophy in patients with multiple sclerosis

Early-stage volume losses in the corpus callosum and thalamus predict the progression of brain atrophy in patients with multiple sclerosis

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