Time course of facial emotion processing in women with borderline personality disorder: an ERP study

Hidalgo, Natalie A. Izurieta; Oelkers-Ax, Rieke; Nagy, Krisztina; Mancke, Falk; Bohus, Martin; Herpertz, Sabine C.; Bertsch, Katja

doi:10.1503/jpn.140215

Cited by 64 publications

(45 citation statements)

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“…Interestingly, face recognition performance of BPD patients was more severely impaired when faces were presented after a negative emotional prime, which confirms stronger influences of emotional information on interpersonal emotion processing in BPD. A more negative processing of neutral, ambiguous, or positive emotional faces was also reported in several other recent studies with relatively large groups of female BPD patients and matched healthy control groups (e.g., Catalan et al [9], Daros et al [10], Izurieta Hidalgo et al [11], Thome et al [12], and van Dijke et al [13]; however, see Lowyck et al [14] where now alterations could be found). Confirmation for a threat hypersensitivity also comes from recent eye-tracking studies, which showed faster and more initial eye movements towards the eyes of angry faces and an inability to disengage attention from fearful eyes in BPD patients [15, 16].…”

Section: Recent Behavioral Findingssupporting

confidence: 71%

“…Furthermore, threat hypersensitivity also seems to be related to alterations in very early stages of visual information processing as has been shown by electroencephalogram recordings during an emotion classification task [11]. Along with an increased negativity bias, patients with BPD showed enhanced occipital P100 amplitudes reflecting an early hyperresponsiveness in parts of the striatal and extrastriatal cortices possibly driven by enhanced fast amygdalar feedback.…”

Section: Neurobiological Correlatesmentioning

confidence: 90%

“…While more BPD symptoms were related to a lower threshold to detect anger and an increased likelihood to misidentify anger in male faces, abuse history was only associated with difficulties in detecting facial happiness, but had no effect on anger detection. In an own study, we also did not find a threat hypersensitivity like in BPD [11] in a group of patients with a current diagnosis of posttraumatic stress disorder without BPD [Schneider et al, in preparation; personal communication]. Contrary to this, Nicol et al [29] found a significant correlation between self-reported childhood traumatization and deficits in the recognition of facial disgust, an emotion, which was neither included in the study of Veague and Hooley [22] nor in our own experiment, among a group of BPD patients.…”

Section: Recent Behavioral Findingsmentioning

confidence: 92%

“…According to a study by Veague and Hooley [22], the above-described negativity bias of female patients with BPD might be most pronounced for pictures of male emotional faces, while the sex of the facial expressions had no effects in an own recent study [11]. The very same tendency to ascribe anger to predominantly happy and ambivalent faces was also found in male patients with BPD and was thus independent of the patients’ sex [Izurieta Hidalgo et al, in preparation; personal communication].…”

Section: Recent Behavioral Findingsmentioning

confidence: 99%

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Behavioral and Neurobiological Correlates of Disturbed Emotion Processing in Borderline Personality Disorder

Bertsch

Hillmann

Herpertz³

2018

Psychopathology

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One of the core symptoms of borderline personality disorder (BPD) is emotion dysregulation, which comprises emotion sensitivity, heightened and labile negative affect, deficient appropriate regulation strategies, and a surplus of maladaptive regulation strategies. Although earlier studies provided some evidence for threat hypersensitivity in terms of a negatively biased perception of other people (“negativity bias”) and deficits in the recognition of full-blown anger, i.e., higher error rates and slower reaction times, researchers have only recently started studying effects of interindividual differences (e.g., sex, impulsivity, aggressiveness) and stimulus complexity as well as associations with early adversity, developmental aspects, or the specificity for BPD. Recent data also suggest a deficit in the detection of positive emotions, which needs to be addressed in more detail since it may prevent the patients from recognizing safety signals and from making positive interpersonal experiences. Neurobiologically, threat hypersensitivity has been related to increased and prolonged amygdala responses, while deficient emotion regulation was associated with reduced prefrontal inhibition of the amygdala. First results suggest that these neural alterations may be modulated by psychotherapeutic treatment focusing on emotion regulation.

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Section: Recent Behavioral Findingssupporting

confidence: 71%

Section: Neurobiological Correlatesmentioning

confidence: 90%

Section: Recent Behavioral Findingsmentioning

confidence: 92%

Section: Recent Behavioral Findingsmentioning

confidence: 99%

See 2 more Smart Citations

Behavioral and Neurobiological Correlates of Disturbed Emotion Processing in Borderline Personality Disorder

Bertsch

Hillmann

Herpertz³

2018

Psychopathology

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“…A related aspect is hypersensitivity to threatening information when processing emotional states of others (4). Patients with BPD tend to detect subtle signals of threat and to focus their attention on threatening interpersonal cues (4)(5)(6). Furthermore, faster initial saccades into the eyes-the most threatening part-of angry faces in patients with BPD suggest approach rather than avoidance behavior to interpersonal threat cues (7).…”

Section: Introductionmentioning

confidence: 99%

Oxytocin Normalizes Approach–Avoidance Behavior in Women With Borderline Personality Disorder

et al. 2020

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Background: Interpersonal deficits are a core symptom of borderline personality disorder (BPD), which could be related to increased social threat sensitivity and a tendency to approach rather than avoid interpersonal threats. The neuropeptide oxytocin has been shown to reduce threat sensitivity in patients with BPD and to modify approach-avoidance behavior in healthy volunteers.Methods: In a randomized, double-blind placebo-controlled between-subject design, 53 unmedicated women with BPD and 61 healthy women participated in an approach-avoidance task 75 min after intranasal substance administration (24 IU of oxytocin or placebo). The task assesses automatic approach-avoidance tendencies in reaction to facial expressions of happiness and anger.Results: While healthy participants responded faster to happy than angry faces, the opposite response pattern, that is, faster reactions to angry than happy faces, was found in patients with BPD. In the oxytocin condition, the "congruency effect" (i.e., faster avoidance of facial anger and approach of facial happiness vice versa) was increased in both groups. Notably, patients with BPD exhibited a congruency effect toward angry faces in the oxytocin but not in the placebo condition.Conclusions: This is the second report of deficient fast, automatic avoidance responses in terms of approach behavior toward interpersonal threat cues in patients with BPD. Intranasally administered oxytocin was found to strengthen avoidance behavior to social threat cues and, thus, to normalize fast action tendencies in BPD. Together with the previously reported oxytocinergic reduction of social threat hypersensitivity, these results suggest beneficial effects of oxytocin on interpersonal dysfunctioning in BPD.

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Oxytocin and Borderline Personality Disorder

Bertsch

Herpertz

2017

Current Topics in Behavioral Neurosciences

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Borderline personality disorder (BPD) is a prevalent and severe mental disorder with affect dysregulation, impulsivity, and interpersonal dysfunction as its core features. Up to now, six studies have been performed to investigate the role of oxytocin in the pathogenesis of BPD. While a beneficial effect of oxytocin on threat processing and stress responsiveness was found, other studies using an oxytocin challenge design presented with rather heterogeneous results. Future studies have to include a sufficiently large sample of patients, control for gender, and focus on mechanisms known to be related to aversive early life experiences.

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Time course of facial emotion processing in women with borderline personality disorder: an ERP study

Cited by 64 publications

References 69 publications

Behavioral and Neurobiological Correlates of Disturbed Emotion Processing in Borderline Personality Disorder

Behavioral and Neurobiological Correlates of Disturbed Emotion Processing in Borderline Personality Disorder

Oxytocin Normalizes Approach–Avoidance Behavior in Women With Borderline Personality Disorder

Oxytocin and Borderline Personality Disorder

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