Time course of effective connectivity associated with perspective taking in utterance comprehension

Abstract

This study discusses the effective connectivity in the brain and its time course in realizing perspective taking in verbal communication through electroencephalogram (EEG) associated with the understanding of Japanese utterances. We manipulated perspective taking in a sentence with the Japanese subsidiary verbs -ageru and -kureru, which mean “to give”. We measured the EEG during the auditory presentation of the sentences with a multichannel electroencephalograph, and the partial directed coherence and its temporal variations were analyzed using the source localization method to examine causal interactions between nineteen regions of interest in the brain. Three different processing stages were recognized on the basis of the connectivity hubs, direction of information flow, increase or decrease in flow, and temporal variation. We suggest that perspective taking in speech comprehension is realized by interactions between the mentalizing network, mirror neuron network, and executive control network. Furthermore, we found that individual differences in the sociality of typically developing adult speakers were systematically related to effective connectivity. In particular, attention switching was deeply concerned with perspective taking in real time, and the precuneus played a crucial role in implementing individual differences.