Time course of DNA methylation in pain conditions: From experimental models to humans

Abstract

The current, revised International Association for the Study of Pain (IASP) definition of pain is as follows: "An unpleasant sensory and emotional experience associated with, or resembling that associated with, actual or potential tissue damage" (Raja et al., 2020). This current definition of pain accentuates that pain is not only a result of tissue damage but is also an individual and personal experience, influenced by many other potential factors. In recent years, it has

Opioids and opioid receptors; understanding pharmacological mechanisms as a key to therapeutic advances and mitigation of the misuse crisis

“… 78 , 79 , 80 , 81 Of relevance to anaesthesia, epigenetics has a role to play in the perioperative period: there are data showing epigenetic links to several types of pain and also opioid addiction-misuse which may have implications for the opioid misuse crisis. 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 …”

Narrative Review of the Complex Interaction between Pain and Trauma in Children: A Focus on Biological Memory, Preclinical Data, and Epigenetic Processes

“…Firstly, epigenetic changes in neurogenesis, cognition, synaptic plasticity, and neurodevelopmental and neurodegenerative diseases are known to be dynamic and unstable [15,253]. Secondly, enduring epigenetic marks can exhibit intergenerational or transgenerational heritability, meaning that epigenetic modifications occurring in germline cells can become stable and persist in subsequent generations even in the absence of the original stimuli [223,254]. Tracking inherited epigenetic information and understanding its effects in subsequent generations poses a significant challenge that needs to be addressed [249].…”

Transient Receptor Potential Ankyrin 1 (TRPA1) Methylation and Chronic Pain: A Systematic Review

“…Recent studies showed that chronic pain can be related to changes in DNA methylation, the prototypical epigenetic mechanism, leading to the modulation of pain pathways from the spinal cord to the cortex [17,18]. Moreover, methylation studies have explored epigenetic modulation in several chronic pain conditions [19][20][21], proving that these alterations can affect pain perception and evoke pathological pain responses [22].…”