Time course of changes in collateral blood flow and isolated vessel size and gene expression after femoral artery occlusion in rats

Prior, Barry M.; Lloyd, Pamela G.; Ren, Jie; Han, Li; Yang, Harrison Hao; Laughlin, M. Harold; Terjung, Ronald L.

doi:10.1152/ajpheart.00398.2004

Cited by 94 publications

(169 citation statements)

References 61 publications

Supporting

Mentioning

151

Contrasting

Unclassified

Order By: Relevance

“…Collateral growth encompasses the proliferation of capillaries in the ischemic area (angiogenesis) and the maturation of preexisting collateral vessels (arteriogenesis), with the latter being more important in terms of increasing the collateral blood flow. [1][2][3][4][5] Therapeutic angiogenesis with growth factors has been introduced for the treatment of PAD, 6,7 but although local delivery of basic fibroblast growth factor (bFGF) augmented collateral circulation in a rabbit hindlimb ischemia model, 8 the limitation of the use of recombinant bFGF lies in its low accumulation in the ischemic tissue and its rapid inactivation in vivo. Gelatin hydrogel microspheres incorporating bFGF have been developed for sustained-release 9 and we recently demonstrated the effectiveness of a sustained-release bFGF system in various pathological conditions, including hindlimb ischemia.…”

mentioning

confidence: 99%

Combined Treatment of Sustained-Release Basic Fibroblast Growth Factor and Sarpogrelate Enhances Collateral Blood Flow Effectively in Rabbit Hindlimb Ischemia

Hirose

Fujita

Marui

et al. 2006

Circ J

View full text Add to dashboard Cite

Background The effectiveness of sustained-release basic fibroblast growth factor (bFGF) in potentiating arteriogenesis and angiogenesis was evaluated, as well as determining whether chronic oral administration of sarpogrelate, a serotonin blocker, would further increase collateral blood flow in the rabbit hindlimb following surgical induction of ischemia by femoral artery extraction. Methods and ResultsTwo weeks after femoral artery removal, the rabbits were assigned to 1 of 4 experimental groups and treated for 4 weeks: group A, no treatment; group B, supplemented with diet containing sarpogrelate; group C, single intramuscular injection of sustained-release form of bFGF microspheres; group D: combined treatment with sustained-release bFGF and sarpogrelate. Endpoint measurements performed at 6 weeks found that the ischemic hindlimb blood flow was significantly improved in the rabbits that received sustained-release bFGF, with a further significant improvement in those with the additional administration of sarpogrelate. Angiographic assessment revealed augmented density of collateral vessels in the medial thigh region in the rabbits given the combined treatment. Conclusions The findings demonstrate that sustained-release bFGF stimulated the development of collateral vessels, and additional administration of sarpogrelate produced a further improvement in hindlimb blood flow in the rabbit hindlimb ischemia model. (Circ J 2006; 70: 1190 -1194

show abstract

mentioning

confidence: 99%

Combined Treatment of Sustained-Release Basic Fibroblast Growth Factor and Sarpogrelate Enhances Collateral Blood Flow Effectively in Rabbit Hindlimb Ischemia

Hirose

Fujita

Marui

et al. 2006

Circ J

View full text Add to dashboard Cite

show abstract

“…While early impairment at day seven and recovery by day 21 are expected and consistent with current collateral research, the alternative pathways and responses of the ACCs and PECs in the Balb/C strain in particular have, previously, been largely unexplored (8,25,48,52,63).…”

Section: Resultssupporting

confidence: 73%

“…If the diameter changes are associated with vessel maturity, the restored capability of ACCs to dilate at day 21 in response to electrode-induced muscle contraction would also be expected in the PECs (8). The impaired capacity for PECs to dilate may correlate with an impaired ability to remodel, as supported by collateral vessels having impaired function in the Balb/C strain, potentially due to a lower expression of VEGF-A (11,52). VEGF-A is a critical cytokine in vascular development and is linked with TNF-α levels, which are specifically important to remodeling in collateral vessels (11,74,76).…”

Section: Mature Pre-existing Collateral Responsesmentioning

confidence: 99%

“…Additionally, the collateral remodeling processes begin immediately following the occlusion in response to the changes in shear stress, such that changes in wall area and blood flow are present within the first few days (25,52). The seven-day time-point, in particular, is used in this study because it is a convenient date for to follow-up regarding experimental logistics, and it is a common date for collateral analysis (25,48,52). After approximately three weeks, these changes level off, supporting 21-days as an appropriate time-point to analyze developed collaterals.…”

Section: Limitations and Future Workmentioning

confidence: 99%

See 1 more Smart Citation

Vascular Reactivity in Newly-Formed and Mature Arterialized Collateral Capillaries

Hellstrom¹

View full text Add to dashboard Cite

“…Our laboratory recently reported, for example, that the reflex is larger in rats whose femoral arteries were ligated 72 h before the start of the experiment than it was in rats whose femoral arteries were freely perfused (36). When the femoral artery of rats is ligated, the collateral circulation provides sufficient blood flow to the hindlimb muscles when they are at rest, but does not provide sufficient flow when they are exercising (30,40). This blood flow pattern to the hindlimb muscles during both rest and exercise closely approximates the blood flow patterns to resting and exercising leg muscles of patients with peripheral arterial disease (4).…”

mentioning

confidence: 99%

Effects of peripheral and spinal κ-opioid receptor stimulation on the exercise pressor reflex in decerebrate rats

Copp

Stone

Yamauchi

et al. 2014

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

Copp SW, Stone AJ, Yamauchi K, Kaufman MP. Effects of peripheral and spinal -opioid receptor stimulation on the exercise pressor reflex in decerebrate rats. Am J Physiol Regul Integr Comp Physiol 307: R281-R289, 2014. First published June 11, 2014 doi:10.1152/ajpregu.00156.2014The exercise pressor reflex is greater in rats with ligated femoral arteries than it is in rats with freely perfused femoral arteries. The exaggerated reflex in rats with ligated arteries is attenuated by stimulation of -opioid and ␦-opioid receptors on the peripheral endings of thin-fiber muscle afferents. The effect of stimulation of -opioid receptors on the exercise pressor reflex is unknown. We tested the hypothesis that stimulation of -opioid receptors attenuates the exercise pressor reflex in rats with ligated, but not freely perfused, femoral arteries. The pressor responses to static contraction were compared before and after femoral arterial or intrathecal injection of the -opioid receptor agonist U62066 (1, 10, and 100 g). Femoral arterial injection of U62066 did not attenuate the pressor responses to contraction in either group of rats. Likewise, intrathecal injection of U62066 did not attenuate the pressor response to contraction in rats with freely perfused femoral arteries. In contrast, intrathecal injection of 10 and 100 g of U62066 attenuated the pressor response to contraction in rats with ligated femoral arteries, an effect that was blocked by prior intrathecal injection of the -opioid receptor antagonist nor-binaltorphimine. In rats with ligated femoral arteries, the pressor response to stimulation of peripheral chemoreceptors by sodium cyanide was not changed by intrathecal U62066 injections, indicating that these injections had no direct effect on the sympathetic outflow. We conclude that stimulation of spinal, but not peripheral, -opioid receptors attenuates the exaggerated exercise pressor reflex in rats with ligated femoral arteries. skeletal muscle afferents; exercise; peripheral artery disease; spiradoline ACTIVATION OF THE EXERCISE pressor reflex is responsible, at least in part, for the cardiovascular and ventilatory adjustments to exercise (13). The afferent arm of the reflex comprises group III and IV muscle afferents, which respond predominantly to mechanical and metabolic stimuli, respectively (14,19). Group III and IV afferents, which together are termed thin-fiber afferents, synapse onto interneurons in the dorsal horn of the spinal cord (10). These interneurons, in turn, project initially to neurons in the ventrolateral medulla and the nucleus of the solitary tract (9, 29), and eventually to autonomic preganglionic neurons. The functional consequences of activating the exercise pressor reflex during exercise include increases in arterial blood pressure, heart rate (HR), and ventilation, all of which contribute to the increases in exercising skeletal muscle blood flow and O 2 delivery (1, 2, 27).In cats, dogs, and rats, acute or chronic muscle ischemia exaggerates the exercise pressor reflex (8,19,27,32,3...

show abstract

Time course of changes in collateral blood flow and isolated vessel size and gene expression after femoral artery occlusion in rats

Abstract: . Terjung. Time course of changes in collateral blood flow and isolated vessel size and gene expression after femoral artery occlusion in rats.

Cited by 94 publications

References 61 publications

Combined Treatment of Sustained-Release Basic Fibroblast Growth Factor and Sarpogrelate Enhances Collateral Blood Flow Effectively in Rabbit Hindlimb Ischemia

Combined Treatment of Sustained-Release Basic Fibroblast Growth Factor and Sarpogrelate Enhances Collateral Blood Flow Effectively in Rabbit Hindlimb Ischemia

Vascular Reactivity in Newly-Formed and Mature Arterialized Collateral Capillaries

Effects of peripheral and spinal κ-opioid receptor stimulation on the exercise pressor reflex in decerebrate rats

Contact Info

Product

Resources

About